其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Fluspirilene CAS Registry Number: 1841-19-6 氟司必林

CAS Name: 8-[4,4-Bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-oneTrademarks: Imap (McNeil); Redeptin (SK F)
Percent Composition: C 73.24%, H 6.57%, F 7.99%, N 8.84%, O 3.36...
Literature References: Prepn: BE 633914; P. A. J. Janssen, US 3238216 (1963, 1966 both to Janssen). HPLC determn: A. H. Hikal, H. I. Al-Shoura, J. Liq. Chromatogr. 5, 2205 (1982). Metabolism in rat: J. P. P. Heykants, Life Sci. 8, Part I, 1029 (1969). Pharmacology: P. A. J. Janssen et al., Arzneim.-Forsch. 20, 1689 (1970). Calcium channel blocking activity: R. J. Gould et al., Proc. Natl. Acad. Sci. USA 80, 5122 (1983); J. P. Galizzi et al., ibid. 83, 7513 (1986). Clinical trials in schizophrenia: H. Immich et al., Arzneim.-Forsch. 20, 1699 (1970); G. Chouinard et al., J. Clin. Psychopharmacol. 6, 21 (1986).

Nifuratel CAS Registry Number: 4936-47-4 硝呋太尔

CAS Name: 5-[(Methylthio)methyl]-3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone
Additional Names: 5-[(methylthio)methyl]-3-[(5-nitrofurfurylidene)amino]-2-oxazolidinone; 5-(methylmerca...
Literature References: Prepn: BE 635608 (1963 to Polichimica SAP), C.A. 61, 16069c (1964), corresp to GB 969126.

Amicibone CAS Registry Number: 23271-63-8 阿米西酮

CAS Name: 1-[2-(Hexahydro-1H-azepin-1-yl)ethyl]-2-oxocyclohexanecarboxylic acid phenylmethyl ester
Additional Names: 2-(b-hexamethyleniminoethyl)cyclohexanone-2-carboxylic acid benzyl ester
...
Literature References: Prepn: BE 639472; BE 639473; Frank et al., AT 237593 (all 1964 to Biochemie GmbH), C.A. 62, 5207e (1965).

Clobenfurol CAS Registry Number: 3611-72-1 氯达香豆素

CAS Name: a-(4-Chlorophenyl)-2-benzofuranmethanol
Additional Names: 2-benzofuryl-p-chlorophenylcarbinol
Trademarks: Menacor (Menarini)
Percent Composition: C 69.64%, H 4.29%, Cl 13.70%, O...
Literature References: Prepn: BE 644176; Ghelardoni, Russo, GB 1160925 (1964, 1969 both to Menarini), C.A. 63, 8319h (1965); 71, 124212f (1969); Ghelardoni, Russo, Boll. Chim. Farm. 109, 48 (1970). Pharmacology of the hemisuccinate deriv: Pisanti, Volterra, Farmaco Ed. Sci. 26, 312 (1971).

Nicomol CAS Registry Number: 27959-26-8 尼可莫尔

CAS Name: 3-Pyridinecarboxylic acid (2-hydroxy-1,3-cyclohexanediylidene)tetrakis(methylene) ester
Additional Names: nicotinic acid 1,1,3,3-tetraester with 2-hydroxy-1,1,3,3-cyclohexanetetrameth...
Literature References: Prepn: BE 658422 corresp to Irikura et al., US 3299077 (1965 and 1967 to Kyorin). Hypocholesterolemic action studies: Aso et al., J. Atheroscler. Res. 10, 391 (1969). Acute toxicity data: T. Sugawara et al., Oyo Yakuri 14, 741 (1977), C.A. 88, 131005v (1977). Review: Jpn. Med. Gaz. 8(8), 9 (1971).

Imiclopazine CAS Registry Number: 7224-08-0 咪克洛嗪

CAS Name: 1-[2-[4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethyl]-3-methyl-2-imidazolidinone
Additional Names: 3-chloro-10-[g-[N'-[b-(1-methyl-2-oxoimidazolidin-3-yl)ethyl]-N-p...
Literature References: Prepn: BE 668972 (1965 to Asta), C.A. 65, 8934f (1966).

Molindone CAS Registry Number: 7416-34-4 3-乙基-2-甲基-5-(吗啉-4-基甲基)-1,5,6,7-四氢吲哚-4-酮

CAS Name: 3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one
Additional Names: 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one
Percent Composition: C...
Literature References: Prepn: BE 670798; I. J. Pachter, K. Schoen, US 3491093 (1966, 1970 both to Endo). Pharmacology: Sugerman, Herrmann, Clin. Pharmacol. Ther. 8, 261 (1967); Claghorn, Curr. Ther. Res. 11, 524 (1969); Guerrero-Figueroa et al., ibid. 15, 508 (1973). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Cinepazide CAS Registry Number: 23887-46-9 桂哌齐特

CAS Name: 1-[2-Oxo-2-(1-pyrrolidinyl)ethyl]-4-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]piperazine
Additional Names: 1-[(1-pyrrolidinylcarbonyl)methyl]-4-(3,4,5-trimethoxycinnamoyl)piperazin...
Literature References: Prepn: BE 730345; C. P. Fauran et al., US 3634411 (1969, 1972 both to Delalande); C. P. Fauran, M. J. Turin, Chim. Ther. 4, 290 (1969). Pharmacology: G. Huguet et al., ibid. 293; E. Marmo et al., Farmaco Ed. Prat. 28, 132 (1973); B. M. Pourrias et al., Therapie 29, 29, 43 (1974).

Troxipide CAS Registry Number: 99777-81-8 拉氧头孢

CAS Name: 3,4,5-Trimethoxy-N-3-piperidinylbenzamide
Additional Names: 3-(3,4,5-trimethoxybenzamido)piperidineTrademarks: Aplace (Kyorin)
Percent Composition: C 61.21%, H 7.53%, N 9.52%, O 21...
Literature References: Prepn: BE 736840; T. Irikura et al., US 3647805 (1969, 1972 both to Kyorin). Anti-ulcer activity: T. Irikura, K. Kasuga, J. Med. Chem. 14, 357 (1971). Pharmacokinetics in man: T. Irikura et al., Iyakuhin Kenkyu 12, 971 (1981), C.A. 96, 79377s (1982). Effect on gastric mucosa in rats: Y. Abe et al., Nippon Yakurigaku Zasshi 83, 317 (1984), C.A. 101, 456g (1984); on glucosamine synthetase: Y. Abe et al., Oyo Yakuri 27, 521 (1984), C.A. 101, 17001c (1984). Metabolism in rats: K. Tagaki et al., ibid. 1151, C.A. 101, 103555t (1984); K. Tagaki, K. Endo, ibid. 1167, C.A. 101, 103556u (1984). Toxicity: T. Irikura et al., Kiso to Rinsho 12, 3422 (1978).

Cifenline CAS Registry Number: 53267-01-9 西苯唑啉

CAS Name: 2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole
Additional Names: (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline; 1-(2-D2-imidazolinyl)-2,2-diphenylcyclopropane; cibenzolineP...
Literature References: Prepn: BE 807630; J. C. Cognaco, US 3903104 (1974, 1975 both to Hexachemie). Activity and tolerance: D. Herpin et al., Acta Cardiol. 36, 131 (1981). Electrophysiological effects in man: J. F. Thizy et al., Lyon Med. 245, 119 (1981). Clinical trial: D. Herpin et al., Curr. Ther. Res. 30, 742 (1981).