其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Dimecrotic Acid CAS Registry Number: 7706-67-4 地美罗酸

CAS Name: 3-(2,4-Dimethoxyphenyl)-2-butenoic acid
Additional Names: 2,4-dimethoxy-b-methylcinnamic acid; 3-(2,4-dimethoxyphenyl)crotonic acid
Percent Composition: C 64.85%, H 6.35%, O 28.80%
Literature References: Prepn: DE 1915023 (1969 to Unicler), C.A. 72, 66630y (1970). TLC determn in pharmaceutics: M.-F. Etcheverry et al., Sci. Tech. Pharm. 7, 51 (1978).

Fenoxedil CAS Registry Number: 54063-40-0 非诺地尔

CAS Name: 2-(4-Butoxyphenoxy)-N-(2,5-diethoxyphenyl)-N-[2-(diethylamino)ethyl]acetamide
Additional Names: 2-(p-butoxyphenyl)-N-[2-(diethylamino)ethyl]-2',5'-diethoxyacetanilide
Percent Compo...
Literature References: Prepn: DE 1964712; Thuillier, Geffroy, US 3818021 (1970, 1974 both to CERPHA).

Emylcamate CAS Registry Number: 78-28-4 依米氨酯

CAS Name: 3-Methyl-3-pentanol carbamate
Additional Names: 1-ethyl-1-methylpropyl carbamate; diethyl methyl carbinol urethan; 3-methyl-3-pentyl carbamate; methyl diethyl carbinol urethan; tert-h...
Literature References: Prepn: DE 245491 (1912 to Chinifabr. Zimmer); DE 254472 (1912 to E. Merck); Melander, Hanshoff, US 2972564 (1961 to Kabi).

Phenylmethylbarbituric Acid CAS Registry Number: 76-94-8 苯甲比妥

CAS Name: 5-Methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-methyl-5-phenylbarbituric acid; 2,4,6-trioxo-5-methyl-5-phenylhexahydropyrimidine
Trademarks: Rutonal (M B)<...
Literature References: Prepn: DE 247952 (1912 to Bayer); Dvornik et al., C.A. 50, 312f (1956).

Bis(4-amino-1-anthraquinonyl)amine CAS Registry Number: 128-87-0 4,4'-二氨基-1,1'-亚氨基二蒽醌

CAS Name: 1,1'-Iminobis[4-amino-9,10-anthracenedione]
Additional Names: 4,4'-diamino-1,1'-dianthraquinonylamine; 4,4'-diamino-1,1'-anthrimide; 4,4'-diamino-1,1'-iminobisanthraquinone
Percent...
Literature References: Prepn: DE 255822 (1913); Frdl. 11, 615; Tinker, Stallmann, US 2420022 (1947), C.A. 41, 5730 (1947).

Chloroarsenol CAS Registry Number: 151-07-5 [(1Z)-2-氯-1-庚烯-1-基]砷酸

CAS Name: (2-Chloro-1-heptenyl)arsonic acid
Additional Names: 2-chloro-1-heptene-1-arsonic acid
Percent Composition: C 32.77%, H 5.50%, As 29.20%, Cl 13.82%, O 18.71%
Literature References: Prepn: DE 296915 (1917 to Bayer).

Acecarbromal CAS Registry Number: 77-66-7 乙酰溴米那

CAS Name: N-[(Acetylamino)carbonyl]-2-bromo-2-ethylbutanamide
Additional Names: N-acetyl-N-bromodiethylacetylurea; acetylbromodiethylacetylcarbamide; N-acetyl-N'-a-bromo-a-ethylbutyrylcarbamide...
Literature References: Prepn: DE 327129 (1920 to Bayer), Frdl. 13, 809 (1923). HPLC determn in plasma, urine: M. Höbel, G. Bender, Arch. Toxicol. 37, 307 (1977). GC-MS screening procedure in urine: H. H. Maurer, J. Chromatogr. 530, 307 (1990).

Acefylline CAS Registry Number: 652-37-9 茶碱乙酸

CAS Name: 1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxopurine-7-acetic acid
Additional Names: carboxymethyltheophylline; 7-theophyllineacetic acid
Percent Composition: C 45.38%, H 4.23%, N 23.52...
Literature References: Prepn: DE 352980 (1922 to E. Merck); Frdl. 14, 1320; S. M. Ride et al., Pharmazie 32, 672 (1977). Prepn of salts: J. Baisse, Bull. Soc. Chim. Fr. 1949, 769; M. Milletti, F. Virgili, Chimica 6, 394 (1951), C.A. 46, 8615h (1952). GC determn in urine: J. Zuidema, H. Hilbers, J. Chromatogr. 182, 445 (1980). HPLC determn in serum and pharmacokinetics: S. Sved et al., Biopharm. Drug Dispos. 2, 177 (1981).

Ethacridine CAS Registry Number: 442-16-0 利凡诺尔

CAS Name: 7-Ethoxy-3,9-acridinediamine
Additional Names: 6,9-diamino-2-ethoxyacridine; 2,5-diamino-7-ethoxyacridine; 2-ethoxy-6,9-diaminoacridine; etakridin
Percent Composition: C 71.13%, H ...
Literature References: Prepn: DE 364033; DE 364037; DE 393411; DE 395683 (1922); Frdl. 14, 804, 807-812; A. Albert, W. Gledhill, J. Soc. Chem. Ind. 61, 159 (1942). Toxicity: S. D. Rubbo, Br. J. Exp. Pathol. 28, 1 (1947); N. J. Joshi et al., Indian J. Exp. Biol. 16, 1038 (1978). Pharmacokinetics: T. J. Rising et al., Arzneim.-Forsch. 27, 872 (1977). Use in protein analysis: R. H. Yue et al., Thromb. Diath. Haemorrh. 31, 439 (1974); F. Franek, Methods Enzymol. 121, 631-638 (1986); in serological detection of Brucella sp.: J. D. Huber, P. Nicoletti, Am. J. Vet. Res. 47, 1529 (1986). Clinical evaluation in diarrhea: N. Madanagopalan et al., Curr. Ther. Res. 18, 546 (1975); R. Raedsch et al., Klin. Wochenschr. 69, 863 (1991); as an abortifacient: S. Gardo, M. Nagy, Arch. Gynecol. Obstet. 247, 39 (1990).

Tricaine CAS Registry Number: 886-86-2 3-乙氧酰基苯胺甲磺酸盐

CAS Name: 3-Aminobenzoic acid ethyl ester methanesulfonate
Additional Names: tricaine methanesulfonate; ethyl m-aminobenzoate methanesulfonateTrademarks: Finquel (Argent)
Percent Composition...
Literature References: Prepn: DE 454698; O. Billeter et al., US 1678317 (both 1928 to Sandoz). Pharmacology in fish: D. W. Jolly et al., Vet. Rec. 91, 424 (1972). Blood concentrations during anesthetization and recovery: A. H. Houston, R. J. Woods, J. Fish Res. Board Can. 29, 1344 (1972). pH effects on anesthetic potency: E. A. Ohr, Comp. Biochem. Physiol. 54C, 13 (1976). Toxicity study: J. M. McKim et al., Environ. Toxicol. Chem. 6, 295 (1987). Use as anesthetic in fish: P. K. Bourne, Aquaculture 36, 313 (1984); on fish larvae: K. C. Massee et al., ibid. 134, 351 (1995); in amphibians: J. Letcher, Zoo Biol. 11, 243 (1992).