其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Bitertanol CAS Registry Number: 55179-31-2 联苯三唑醇

CAS Name: b-[(1,1'-Biphenyl)-4-yloxy]-a-(1,1-dimethylethyl)-1H-1,2,4-triazol-1-ethanol
Additional Names: 1-(biphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; biloxazolTrademar...
Literature References: Prepn: BE 814831; W. Kramer et al., US 3952002 (1974, 1976 both to Bayer AG). Physical properties and fungicidal activity: W. Brandes et al., Pflanzenschutz-Nachr. 32, 1 (1979). Mechanism of action: P. Kraus, ibid. 17; S. V. Overton et al., J. Hortic. Sci. 63, 183 (1988). GC determn in plants, soil and water: R. Brennecke, Pflanzenschutz-Nachr. 38, 33 (1985). Resolution of diastereomers: R. S. Burden et al., J. Chromatogr. 391, 273 (1987). In vitro activity: T. B. Sutton et al., Plant Dis. 69, 700 (1985). Field use in control of apple diseases: K. S. Yoder, ibid. 66, 580 (1982); W. F. S. Schwabe, Pflanzenschutz-Nachr. 35, 125 (1982); in wheat seed pretreatment: J. A. Hoffmann, D. V. Sisson, Plant Dis. 71, 839 (1987).

IPBC CAS Registry Number: 55406-53-6 碘丙炔基正丁氨基甲酸酯(IPBC)

CAS Name: Butylcarbamic acid 3-iodo-2-propynyl ester
Additional Names: 3-iodo-2-propynyl butylcarbamate
Trademarks: Glycacil (Lonza); Polyphase P-100 (Kop-Coat)
Percent Composition: C 34....
Literature References: Prepn: BE 817530; W. Singer, US 3923870 (both 1975 to Troy Chemical). Aquatic toxicities: A. P. Farrell et al., Arch. Environ. Contam. Toxicol. 35, 472 (1998); fate and behavior: L. Juergensen et al., Environ. Toxicol. 15, 201 (2000). HPLC-MS determn in cosmetic formulations: M. Frauen et al., J. Pharm. Biomed. Anal. 25, 965 (2001). GC-MS determn of degradation products: K. G. Karaisz, N. H. Snow, J. Microcol. Separat. 13, 1 (2001). Review of use in wood protection: J. Hansen, Mod. Paint Coat. 74, 50-56, 90 (1984); of microbial activities and commerical uses: R. Gruening, Cosmet. Toiletries 112, 59-65 (1997).

Alizapride CAS Registry Number: 59338-93-1 阿立必利

CAS Name: 6-Methoxy-N-[[1-(2-propenyl)-2-pyrrolidinyl]methyl]-1H-benzotriazole-5-carboxamide
Additional Names: N-[(1-allyl-2-pyrrolidinyl)methyl]-6-methoxy-1H-benzotriazole-5-carboxamide
Per...
Literature References: Prepn: BE 825605; G. Bulteau et al., US 4039672 (1975, 1977 both to Soc. d'Etudes Sci. Ind. de l'Ile-de-France). Series of articles on pharmacology and clinical studies in chemotherapy induced emesis: Sem. Hop. 58, 323-374 (1982).

Pirazolac CAS Registry Number: 71002-09-0 吡拉唑酸

CAS Name: 4-(4-Chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-acetic acidPercent Composition: C 61.73%, H 3.66%, Cl 10.72%, F 5.74%, N 8.47%, O 9.67%
Literature References: Prepn: BE 844972; H. Ahrens et al., US 4042706 (both 1977 to Schering AG); H. Biere et al., Eur. J. Med. Chem. - Chim. Ther. 17, 27 (1982). Pharmacokinetics: U. Täuber et al., Eur. J. Drug Metab. Pharmacokinet. 10, 41 (1985). Effect on arachidonic acid metabolism in human synovia: M. Kurowski et al., Curr. Med. Res. Opin. 10, 494 (1987). Preliminary clinical trial in rheumatoid arthritis: D. Symmons et al., ibid. 9, 542 (1985).

Diclobutrazol CAS Registry Number: 75736-33-3 苄氯三唑醇

CAS Name: (aR,bR)-rel-b-[(2,4-Dichlorophenyl)methyl]-a-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol
Additional Names: 1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pentan-3-ol; 1...
Literature References: Prepn: BE 857836; S. Balasubramanyan, M. C. Shephard, US 4243405 (1978, 1981 both to ICI). Activity, physical properties, and toxicity: K. J. Bent, A. M. Skidmore, Proc. Br. Crop Prot. Conf. - Pests Dis. 1979, 477. Fungicidal activity: B. Ram et al., Tests Agrochem. Cultiv. 3, 38 (1982). Regulation of plant growth: J. B. Shanks, Proc. Plant Growth Regul. Soc. Am. 9, 68 (1982). Mechanism of action: P. Gadher et al., Pestic. Biochem. Physiol. 19, 1 (1983); T. E. Wiggins, B. C. Baldwin, Pestic. Sci. 15, 206 (1984). Resolution of enantiomers by GC: R. S. Burden et al., J. Chromatogr. 391, 273 (1987).

Repirinast CAS Registry Number: 73080-51-0 瑞吡司特

CAS Name: 5,6-Dihydro-7,8-dimethyl-4,5-dioxo-4H-pyrano[3,2-c]quinoline-2-carboxylic acid 3-methylbutyl ester
Additional Names: isopentyl 5,6-dihydro-7,8-dimethyl-4,5-dioxo-4H-pyrano[3,2-c]quino...
Literature References: Prepn: BE 876751; Y. Morinaka, K. Takahashi, US 4298610 (1979, 1981 both to Mitsubishi Yuka); Y. Morinaka et al., Eur. J. Med. Chem. - Chim. Ther. 16, 251 (1981). General pharmacology in animals: K. Takahashi et al., Oyo Yakuri 32, 233 (1986), C.A. 105, 218691j (1986). Anti-allergic effects: S. Kono, K. Ohata, Arerugi 35, 1105 (1986), C.A. 106, 165870z (1987). Toxicity: M. Nagase et al., Iyakuhin Kenkyu 17, 545 (1986), C.A. 106, 108121r (1987).

Oxolamine CAS Registry Number: 959-14-8 奥索拉明

CAS Name: N,N-Diethyl-3-phenyl-1,2,4-oxadiazole-5-ethanamine
Additional Names: 5-(2-diethylaminoethyl)-3-phenyl-1,2,4-oxadiazole; 3-phenyl-5-(b-diethylaminoethyl)-1,2,4-oxadiazolePercent Compos...
Literature References: Prepn: DE 1097998 (1961 to Angelini Francesco), C.A. 56, 11598h (1962). Teratogenicity studies of oxolamine citrate: L. Nilsson, Arzneim.-Forsch. 17, 781 (1967).

Sulfameter CAS Registry Number: 651-06-9 磺胺对甲氧嘧啶

CAS Name: 4-Amino-N-(5-methoxy-2-pyrimidinyl)benzenesulfonamide
Additional Names: N1-(5-methoxy-2-pyrimidinyl)sulfanilamide; sulfa-5-methoxypyrimidine; 2-sulfanilamido-5-methoxypyrimidine; 2-(p...
Literature References: Prepn: DE 1101428; P. Diedrich, US 3214335 (1961, 1965 both to Schering AG); Horstmann et al., Arzneim.-Forsch. 11, 682 (1961); Budesinky et al., Experientia 17, 129 (1961); CS 98818; BE 633513 (1963 to SPOFA); Collect. Czech. Chem. Commun. 29, 2980 (1964). Toxicity study: G. Hecht et al., Arzneim.-Forsch. 11, 695 (1961). Toxicology, chemotherapeutics and pharmacokinetics: Böhne et al., Chemotherapy 14, 195-226 (1969).

Iodochlorhydroxyquin CAS Registry Number: 130-26-7 5-氯-8-羟基-7-碘喹啉

CAS Name: 5-Chloro-7-iodo-8-quinolinol
Additional Names: 5-chloro-8-hydroxy-7-iodoquinoline; chloroiodoquin; iodochlorohydroxyquinoline; iodochloroxyquinoline; clioquinol
Trademarks: Amebil;...
Literature References: Prepn: DE 117767 (1899 to Ciba); US 641491 (1900); A. Das, S. L. Mukherji, J. Org. Chem. 22, 1111 (1957). Toxicity study: Davis et al., Am. J. Trop. Med. 24, 29 (1944). Comprehensive description: G. Padmanabhan et al., Anal. Profiles Drug Subs. 18, 57-90 (1989).

Diethylbromoacetamide CAS Registry Number: 511-70-6 2-溴-2-乙基丁酰胺

CAS Name: 2-Bromo-2-ethylbutanamide
Additional Names: 2-bromo-2,2-diethylacetamide; carbromide
Percent Composition: C 37.13%, H 6.23%, Br 41.17%, N 7.22%, O 8.24%
Literature References: Prepn: DE 158220 (1905 to Kalle).