其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

p-Aminosalicylic Acid CAS Registry Number: 65-49-6 对氨基水杨酸

CAS Name: 4-Amino-2-hydroxybenzoic acid
Additional Names: 4-aminosalicylic acid; PAS
Trademarks: PASER (Jacobus); Rezipas (BMS)
Percent Composition: C 54.90%, H 4.61%, N 9.15%, O 31.34%
Literature References: Prepn: DE 50835 (1889); US 427564 (1890); Sheehan, J. Am. Chem. Soc. 70, 1665 (1948); Erlenmeyer et al., Helv. Chim. Acta 31, 988 (1948); Wenis, Gardner, J. Am. Pharm. Assoc. 38, 9 (1949); Centolella, US 2844625 (1958 to Miles). Toxicity study: E. M. Bavin et al., J. Pharm. Pharmacol. 2, 764 (1950). Comprehensive description: M. M. A. Hassan et al., Anal. Profiles Drug Subs. 10, 1-27 (1981).

Methetoin CAS Registry Number: 5696-06-0 美替妥英

CAS Name: 5-Ethyl-1-methyl-5-phenyl-2,4-imidazolidinedione
Additional Names: 5-ethyl-1-methyl-5-phenylhydantoin; 1-methylnirvanol; 1-methyl-5-ethyl-5-phenylhydantoin
Trademarks: Deltoin (San...
Literature References: Prepn: DE 611057 (1935 to Sandoz); Long et al., J. Am. Chem. Soc. 70, 900 (1948).

Dowicide 9® (Dow) CAS Registry Number: 13347-42-7 2-环戊基-4-氯苯酚

CAS Name: 4-Chloro-2-cyclopentylphenol
Percent Composition: C 67.18%, H 6.66%, Cl 18.03%, O 8.14%
Literature References: Prepn: DE 615448 (1935 to Hoffmann-La Roche), C.A. 29, 62481 (1935); Pajeau, Begue, Bull. Soc. Chim. Fr. 1962, 1923. Bactericidal properties: NL 6513777; Lorah, US 3323988 (1966, 1967 both to Dow).

Phenacaine Hydrochloride CAS Registry Number: 620-99-5 乙氨酰胺,N,N'-双(4-乙氧基苯基)-,盐酸盐(1:1)

CAS Name: N,N'-Bis(4-ethoxyphenyl)ethanimidamide monohydrochloride
Additional Names: N1,N2-bis(p-ethoxyphenyl)acetamidine hydrochloride
Trademarks: Holocaine Hydrochloride (Winthrop)
Perc...
Literature References: Prepn: DE 79868; DE 80568.

Fencamine CAS Registry Number: 28947-50-4 1,3,7-三甲基-8-({2-[甲基(1-苯基-2-丙基)氨基]乙基}氨基)-3,7-二氢-1H-嘌呤-2,6-二酮

CAS Name: 3,7-Dihydro-1,3,7-trimethyl-8-[[2-[methyl(1-methyl-2-phenylethyl)amino]ethyl]amino]-1H-purine-2,6-dione
Additional Names: 8-[[2-[methyl(a-methylphenethyl)amino]ethyl]amino]caffeine; 8...
Literature References: Prepn: ES 347509; ES 352077 (both 1969 to Labs. Miquel); Pitarch et al., Quim. Ind. (Madrid) 17, 71 (1971). Pharmacology: eidem, ibid. 76. Colorimetric and TLC determn in urine: J. Mallol et al., Arzneim.-Forsch. 24, 1301 (1974). Toxicity data: E. Usdin, D. H. Efron, Psychotropic Drugs and Related Compounds (National Institute of Mental Health, Rockville, MD, 2nd ed., 1972) p 229. Clinical trial in depression: P. G. Quiros e Isla, Rev. Clin. Esp. 119, 437 (1970).

Tritoqualine CAS Registry Number: 14504-73-5 曲托喹啉

CAS Name: 7-Amino-4,5,6-triethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone
Additional Names: 7-amino-4,5,6-triethoxy-3-(5,6,7,8-tetrah...
Literature References: Prepn: FR 1295309 (1962 to Lab. de Recherches Biol. Laborec). Activity: Hahn et al., Arzneim.-Forsch. 20, 1490 (1970).

Nifuroxazide CAS Registry Number: 965-52-6 硝呋酚酰肼

CAS Name: 4-Hydroxybenzoic acid [(5-nitro-2-furanyl)methylene]hydrazide
Additional Names: p-hydroxybenzoic acid (5-nitrofurfurylidene)hydrazide; 1-(p-hydroxybenzoyl)-2-(5-nitrofurfurylidene)hyd...
Literature References: Prepn: FR 1327840 (1963 to Robert et Carriere), C.A. 59, 12763b (1963); M. C. E. Carron, GB 962706; idem, US 3290213 (1964, 1966 both to Robert et Carriere). Antiseptic and antibacterial properties: M. C. E. Carron et al., Ann. Pharm. Fr. 21, 287 (1963). In vitro study of activity spectrum: A. Thabaut, J. L. Durosoir, Gaz. Med. Fr. 85, 4516 (1978), C.A. 90, 1487 (1979).

Apazone CAS Registry Number: 13539-59-8 阿扎丙宗

CAS Name: 5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione
Additional Names: 3-dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazi...
Literature References: Prepn: FR 1440629; I. Molnar et al., US 3349088 (1966, 1967, both to Siegfried); Mixich, Helv. Chim. Acta 51, 532 (1968). Pharmacological and toxicological studies: Jahn, Adrian, Arzneim.-Forsch. 19, 36 (1969). Metabolism: Mixich, Helv. Chim. Acta 55, 1031 (1972). HPLC determn in plasma and urine: B. J. Kline et al., Arzneim.-Forsch. 33, 504 (1983).

Fominoben CAS Registry Number: 18053-31-1 福米诺苯

CAS Name: N-[3-Chloro-2-[[methyl-[2-(4-morpholinyl)-2-oxoethyl]amino]methyl]phenyl]benzamide
Additional Names: 3'-chloro-a-[methyl[(morpholinocarbonyl)methyl]amino]-o-benzotoluidide; 3'-chloro-...
Literature References: Prepn: FR 1482547; FR Addn. 92488 (1967, 1968 both to Thomae), C.A. 68, 95494e (1968); 72, 21938p (1970); Kruger et al., US 3661903 (1972 to Boehringer, Ing.); eidem, Arzneim.-Forsch. 23, 290 (1973). Series of articles on pharmacology and clinical findings: ibid. 296-375. Metabolism: Zimmer, ibid. 1798. Toxicity data: S. Püschmann, R. Engelhorn, ibid. 296.

Nitroscanate CAS Registry Number: 19881-18-6 1-异硫氰酸基-4-(4-硝基苯氧基)苯

CAS Name: 1-Isothiocyanato-4-(4-nitrophenoxy)benzene
Additional Names: isothiocyanic acid p-(p-nitrophenoxy)phenyl ester; p-(p-nitrophenoxy)phenyl isothiocyanate; 1-(4-isothiocyanatophenoxy)-4-...
Literature References: Prepn: FR 1491477 (1967 to Agripat); F. Paltauf et al., US 3697555 (1972 to Ciba-Geigy); A. Martvon, K. Antos, Chem. Zvesti 23, 181 (1969). Activity in dogs: M. A. Gemmell, G. Oudemans, Res. Vet. Sci. 19, 217 (1975).