网站主页>>>项目整合精选>>>项目整合精选>>>Fencamine CAS Registry Number: 28947-50-4 1,3,7-三甲基-8-({2-[甲基(1-苯基-2-丙基)氨基]乙基}氨基)-3,7-二氢-1H-嘌呤-2,6-二酮

Fencamine CAS Registry Number: 28947-50-4 1,3,7-三甲基-8-({2-[甲基(1-苯基-2-丙基)氨基]乙基}氨基)-3,7-二氢-1H-嘌呤-2,6-二酮

CAS Name: 3,7-Dihydro-1,3,7-trimethyl-8-[[2-[methyl(1-methyl-2-phenylethyl)amino]ethyl]amino]-1H-purine-2,6-dione
Additional Names: 8-[[2-[methyl(a-methylphenethyl)amino]ethyl]amino]caffeine; 8-[2-(N,a-dimethyl-b-phenyl)ethylamino]-1,3,7-trimethyl-2,6-dioxopurine; N1-(1,3,7-trimethyl-2,6-dioxopurin-8-yl)-N2-(1-methyl)phenethyl-N2-methylethylenediamine; N-8-caffeyl-N'-methyl-N'-(a-methylphenethyl)ethylenediamine; phencaminePercent Composition: C 62.48%, H 7.34%, N 21.86%, O 8.32%

📌 参考资料/链接：
Literature References: Prepn: ES 347509; ES 352077 (both 1969 to Labs. Miquel); Pitarch et al., Quim. Ind. (Madrid) 17, 71 (1971). Pharmacology: eidem, ibid. 76. Colorimetric and TLC determn in urine: J. Mallol et al., Arzneim.-Forsch. 24, 1301 (1974). Toxicity data: E. Usdin, D. H. Efron, Psychotropic Drugs and Related Compounds (National Institute of Mental Health, Rockville, MD, 2nd ed., 1972) p 229. Clinical trial in depression: P. G. Quiros e Isla, Rev. Clin. Esp. 119, 437 (1970).

📄 详细内容

Properties: Crystals from methanol, mp 150-152°.
Melting point: mp 150-152°
Derivative Type: Hydrochloride
CAS Registry Number: 63918-50-3
Trademarks: Altimina (Miquel); Sicoclor (Gramon)
Percent Composition: C 57.07%, H 6.94%, N 19.96%, O 7.60%, Cl 8.42%
Properties: Slightly hygroscopic, bitter crystals, decomp 278-279°. uv max (water): 296 nm (E1%1cm 398). Sol in water; slightly sol in many organic solvents. LD50 in rats, mice (mg/kg): 93, 82 i.p.; 508, 418 orally (Usdin, Efron).
Absorption maximum: uv max (water): 296 nm (E1%1cm 398)
Toxicity data: LD50 in rats, mice (mg/kg): 93, 82 i.p.; 508, 418 orally (Usdin, Efron)
Therap-Cat: Analeptic.
Keywords: Antidepressant; Bicyclics.
产品链接: 28947-50-4››

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