其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Glafenine CAS Registry Number: 3820-67-5 格拉非宁

CAS Name: 2-[(7-Chloro-4-quinolinyl)amino]benzoic acid 2,3-dihydroxypropyl ester
Additional Names: N-(7-chloro-4-quinolyl)anthranilic acid 2,3-dihydroxypropyl ester; 4-[(2-carboxyphenyl)amino]-...
Literature References: Prepn: FR M2413; A. Allais, J. Meier, US 3232944 (1964, 1966 both to Roussel-UCLAF); G. Mouzin et al., Synthesis 1980, 54. HPLC determn in plasma: M.-C. Tournet et al., J. Chromatogr. 224, 348 (1981). Biotransformation in the rat and man: J. Pottier et al., Eur. J. Drug Metab. Pharmacokinet. 4, 109 (1979). Bioavailability, absorption: F. Moolenaar et al., Int. J. Pharm. 4, 195 (1980). Alkalimetric determn: M. S. Tawakkol et al., Pharmazie 36, 163 (1981). Comprehensive description: A. A. Badwan et al., Anal. Profiles Drug Subs. Excip. 21, 197-232 (1992).

Pentorex CAS Registry Number: 434-43-5 喷托雷司

CAS Name: a,a,b-Trimethylbenzeneethanamine
Additional Names: a,a,b-trimethylphenethylamine; 1,1-dimethyl-2-phenylpropylamine; DL-2-phenyl-3-methyl-3-butylamine; phenpentermine
Percent Compos...
Literature References: Prepn: FR M2594 (1964 to Nordmark), C.A. 61, 16013f (1964). GC determn in plasma and urine: F. T. Delbeke, M. Debackere, J. Chromatogr. 273, 141 (1983).

Simetride CAS Registry Number: 154-82-5 西美曲特

CAS Name: 1,4-Bis[(2-methoxy-4-propylphenoxy)acetyl]piperazinePercent Composition: C 67.45%, H 7.68%, N 5.62%, O 19.25%
Literature References: Prepn: FR M2936 (1964 to Kyorin Pharmaceutical Co., Ltd.); T. Irikura et al., US 3184463 (1965). Pharmacological studies: T. Irikura et al., Yakugaku Zasshi 83, 785 (1963), C.A. 60, 1008b (1964). Analgesic activity: K. Nishino et al., Yakugaku Zasshi 85, 715 (1965), C.A. 63, 16957b (1965).

Guanacline CAS Registry Number: 1463-28-1 胍那克林

CAS Name: [2-(3,6-Dihydro-4-methyl-1(2H)-pyridinyl)ethyl]guanidine
Additional Names: N-(2-guanidinoethyl)-4-methyl-D3-piperidine; N-(2-guanidinoethyl)-4-methyl-1,2,3,6-tetrahydropyridine; 1-(2-...
Literature References: Prepn: FR M3016 (1965 to Bayer), C.A. 62, 16206b (1965).

Butalamine CAS Registry Number: 22131-35-7 布他拉胺

CAS Name: N,N-Dibutyl-N'-(3-phenyl-1,2,4-oxadiazol-5-yl)-1,2-ethanediamine
Additional Names: 5-[[2-(dibutylamino)ethyl]amino]-3-phenyl-1,2,4-oxadiazole; 3-phenyl-5-(dibutylaminoethylamino)-1,2,...
Literature References: Prepn: FR M3334; Aron-Samuel, Sterne, US 3338899 (1965, 1967 to Aron-Samuel). Pharmacology and toxicity studies: J. Sterne et al., Therapie 24, 735 (1969); J. Sterne, ibid. 745; J. L. Fontaine, R. Fontaine, ibid. 25, 961 (1970).

Flurbiprofen CAS Registry Number: 5104-49-4 氟比洛芬

CAS Name: 2-Fluoro-a-methyl[1,1'-biphenyl]-4-acetic acid
Additional Names: 2-(2-fluoro-4-biphenylyl)propionic acid; 3-fluoro-4-phenylhydratropic acidTrademarks: Adfeed (Lead Chem.); Ansaid (Pfi...
Literature References: Prepn: FR M5737; Adams et al., US 3755427 (1968, 1973 both to Boots Co., Ltd.). Pharmacology: Chalmers et al., Ann. Rheum. Dis. 31, 319 (1972); ibid. 32, 58 (1973); Glenn et al., Agents Actions 3, 210 (1973); Nishizawa et al., Thromb. Res. 3, 577 (1973). HPLC determn in urine and plasma: J. M. Hutzler et al., J. Chromatogr. B 749, 119 (2000). Symposium on pharmacokinetics and clinical efficacy in pain management: Am. J. Med. 80, Suppl. 3A, 1-157 (1986).

Pipotiazine CAS Registry Number: 39860-99-6 哌泊噻嗪

CAS Name: 10-[3-[4-(2-Hydroxyethyl)-1-piperidinyl]propyl]-N,N-dimethyl-10H-phenothiazine-2-sulfonamide
Additional Names: 2-[1-[3-[2-[(dimethylamino)sulfonyl]-10H-phenothiazin-10-yl]propyl]-4-pi...
Literature References: Prepn: FR M7835 (1970 to Rhône-Poulenc), C.A. 78, 43499x (1973). Pharmacokinetics: P. J. De Schepper et al., Arzneim.-Forsch. 29, 1056 (1979); and HPLC determn in plasma: D. A. Ogden et al., J. Pharm. Biomed. Anal. 7, 1273 (1989). Series of articles on pharmacology and clinical use: Acta Psychiat. Scand., Suppl. 241, 9-138 (1973). Toxicity: L. Julou et al., ibid. 9.

Imidocarb CAS Registry Number: 27885-92-3 双咪苯脲

CAS Name: N,N'-Bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea
Additional Names: 3,3'-di-2-imidazolin-2-ylcarbanilide
Percent Composition: C 65.50%, H 5.79%, N 24.12%, O 4.59%
Literature References: Prepn: GB 1007334; R. Fischer, R. Hirt, US 3338917 (1965, 1967 both to Wander). Babesicidal effect in mice and rats: G. Schmidt et al., Res. Vet. Sci. 10, 530 (1969); E. Beveridge, ibid. 534. Effect on exptl anaplasmosis in calves: T. O. Roby, ibid. 13, 519 (1972). Comparison of the dipropionate and tetracycline, q.v., in canine ehrlichiosis: J. E. Price, T. T. Dolan, Vet. Rec. 107, 275 (1980). Efficacy in Babesia felis infection: F. T. Potgieter, J. S. Afr. Vet. Assoc. 52, 289 (1981). Effect on B. ovis infection in sheep: S. A. Michael, A. H. El Refaii, Trop. Anim. Health Prod. 14, 1 (1982), C.A. 96, 192991 (1982).

Protizinic Acid CAS Registry Number: 54323-85-2

CAS Name: 7-Methoxy-a,10-dimethyl-10H-phenothiazine-2-acetic acid
Additional Names: 7-methoxy-a,10-dimethylphenothiazine-3-acetic acid; 2-(7-methoxy-10-methyl-2-phenothiazinyl)propionic acid Literature References: Prepn: GB 1048680; Farge et al., US 3450698; eidem, ZA 6800435, C.A. 70, 68394g (1969) (1966, 1969, 1968 all to Rhône-Poulenc).

Caroxazone CAS Registry Number: 18464-39-6 卡罗沙酮

CAS Name: 2-Oxo-2H-1,3-benzoxazine-3(4H)-acetamide
Additional Names: 3-acetamide-4H-1,3-benzoxazin-2-one; 4H-3-methylcarboxamide-3-benzoxazine-2-one; 4H-3-carbamoylmethyl-1,3-benzoxazin-2-oneTr...
Literature References: Prepn: GB 1115759; L. Bernardi et al., US 3427313 (1965, 1969 both to Soc. Farma. Italia); and pharmacological properties: eidem, Experientia 24, 774 (1968). Pharmacology: G. K. Suchowsky, L. Pegrassi, Arzneim.-Forsch. 19, 643 (1969); G. K. Suchowsky et al., Eur. J. Pharmacol. 6, 327 (1969). Clinical study: S. Cecchini et al., J. Int. Med. Res. 6, 388 (1978).