其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Diathymosulfone CAS Registry Number: 5964-62-5 地百里砜

CAS Name: 4,4'-[Sulfonylbis(4,1-phenyleneazo)]bis[5-methyl-2-(1-methylethyl)]phenol
Additional Names: 6,6'-[sulfonylbis(p-phenyleneazo)]dithymol; bis[p-(4-hydroxy-2-methyl-5-isopropylphenylazo)...
Literature References: Prepn: GB 758744 (1956 to Lab. Laborec); Chiarlo et al., Arch. Ital. Sci. Farmacol. 7, 167 (1957), C.A. 51, 16949c (1957).

Fomocaine CAS Registry Number: 17692-39-6 福莫卡因

CAS Name: 4-[3-[4-(Phenoxymethyl)phenyl]propyl]morpholine
Additional Names: 4-[3-(a-phenoxy-p-tolyl)propyl]morpholineTrademarks: Erbocain (Heilit)
Percent Composition: C 77.14%, H 8.09%, N 4...
Literature References: Prepn: GB 786128 (1957 to Promonta), C.A. 52, 9225h (1958); H. Oelschläger, Arzneim.-Forsch. 9, 313 (1959). Improved synthesis: eidem, ibid. 27, 1625 (1977). Pharmacology: O. Nieschulz et al., ibid. 8, 539 (1958). Metabolism: H. Blume, H. Oelschläger, ibid. 28, 956 (1978). Bioavailability and local anesthetic effect: H. Oelschläger, D. Rothley, ibid. 29, 693 (1979).

Acetamidoeugenol CAS Registry Number: 305-13-5 醋胺丁香酚

CAS Name: N,N-Diethyl-2-[2-methoxy-4-(2-propenyl)phenoxy]acetamide
Additional Names: 2-(4-allyl-2-methoxyphenoxy)-N,N-diethylacetamide; N,N-diethyl-2-methoxy-4-allylphenoxyacetamide; 2-methoxy-...
Literature References: Prepn: GB 792490; GB 837995 (1958, 1960 to Geigy).

Bibenzonium Bromide CAS Registry Number: 15585-70-3 比苯溴铵

CAS Name: 2-(1,2-Diphenylethoxy)-N,N,N-trimethylethanaminium bromide
Additional Names: [2-(1,2-diphenylethoxy)ethyl]trimethylammonium bromide; trimethyl-(1,2-diphenylethoxy)ethylammonium bromid...
Literature References: Prepn: GB 796364; H. Suter, W. Kündig, US 2913459 (1958, 1959 both to Eprova).

Vetrabutine CAS Registry Number: 3735-45-3 维曲布汀

CAS Name: a-(3,4-Dimethoxyphenyl)-N,N-dimethylbenzenebutanamine
Additional Names: N,N-dimethyl-a-(3-phenylpropyl)veratrylamine; 1-(3,4-dimethoxyphenyl)-1-dimethylamino-4-phenylbutane; 3,4-dimet...
Literature References: Prepn: GB 802723 (1958 to Thomae).

Prolintane CAS Registry Number: 493-92-5 普罗林坦

CAS Name: 1-[1-(Phenylmethyl)butyl]pyrrolidine
Additional Names: 1-(a-propylphenethyl)pyrrolidine; 1-phenyl-2-pyrrolidylpentane; phenylpyrrolidinopentanePercent Composition: C 82.89%, H 10.67%,...
Literature References: Prepn: GB 807835; Seeger, Kottler, DE 1093799 (1959, 1960 both to Thomae), C.A. 55, 19950c (1961). Pharmacological studies: R. Kadatz, E. Pötzsch, Arzneim.-Forsch. 7, 344 (1957); K. Takagi et al., Oyo Yakuri 5, 5 (1971), C.A. 76, 94575k (1972).

Phenbutamide CAS Registry Number: 3149-00-6 1-丁基-3-苯磺酰基脲

CAS Name: N-[(Butylamino)carbonyl]benzenesulfonamide
Additional Names: 1-butyl-3-(phenylsulfonyl)urea; N-benzenesulfonyl-N'-butylurea; fenbutamideTrademarks: Diaperos (Merieux); Ipoglon (Diana)...
Literature References: Prepn: GB 808071 (1959 to Hoechst), C.A. 53, 14056c (1959); Hokfelt, Joenssen, J. Med. Pharm. Chem. 5, 231 (1962); Brzozowaki, Rocz. Chem. 43, 1761 (1969). Activity studies: Tonse et al., Nature 193, 891 (1962); Khurana et al., Indian J. Med. Res. 55, 1084 (1967).

Diisopromine CAS Registry Number: 5966-41-6 地索普明

CAS Name: N,N-Bis(1-methylethyl)-g-phenylbenzenepropanamine
Additional Names: N,N-diisopropyl-3,3-diphenylpropylamine; 1,1-diphenyl-3-diisopropylaminopropane; disopromine
Percent Composition...
Literature References: Prepn: GB 808158 (1959 to N. V. Nederland. Comb. voor Chem. Ind. and Janssen, N. V.).

Clocinizine CAS Registry Number: 298-55-5 氯西尼嗪

CAS Name: 1-[(4-Chlorophenyl)phenylmethyl]-4-(3-phenyl-2-propenyl)piperazine
Additional Names: 1-(p-chloro-a-phenylbenzyl)-4-cinnamylpiperazine; 1-cinnamyl-4-(4-chlorobenzhydryl)piperazine; cli...
Literature References: Prepn: GB 809760 (1959 to Janssen). HPLC determn in cough-cold preparations: G. Cavazzutti et al., J. Liq. Chromatogr. 18, 227 (1995).

Trifluomeprazine CAS Registry Number: 2622-37-9 三氟美嗪

CAS Name: N,N,b-Trimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine
Additional Names: 10-[3-(dimethylamino)-2-methylpropyl]-2-(trifluoromethyl)phenothiazinePercent Composition: C 62....
Literature References: Prepn: GB 813861 corresp to G. E. Ullyot, US 2921069 (1959, 1962 both to SKF). Metabolism study: T. L. Flanagan et al., J. Pharm. Sci. 51, 996 (1962). Chromatographic studies: M. W. Anders, G. J. Mannering, J. Chromatogr. 7, 258 (1962); R. J. Warren et al., J. Pharm. Sci. 55, 144 (1966); B. B. Wheals, J. Chromatogr. 187, 65 (1980). Pharmacological studies: R. C. Kelsey, G. J. Frishmuth, Arch. Int. Pharmacodyn. Ther. 173, 44 (1968); E. W. Baur, J. Pharmacol. Exp. Ther. 177, 219 (1971).