其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Styramate CAS Registry Number: 94-35-9 司替氨酯

CAS Name: 1-Phenyl-1,2-ethanediol 2-carbamate
Additional Names: carbamic acid b-hydroxyphenethyl ester; 2-phenyl-2-hydroxyethyl carbamate; 2-hydroxy-2-phenylethyl carbamate
Percent Compositi...
Literature References: Prepn: GB 841626; C. D. Bossinger, K. G. Taylor, US 3265728 (1960, 1966 both to Armour). Pharmacology: De Salva et al., J. Pharmacol. Exp. Ther. 126, 318 (1959).

Oxymesterone CAS Registry Number: 145-12-0 羟甲睾酮

CAS Name: (17b)-4,17-Dihydroxy-17-methylandrost-4-en-3-one
Additional Names: 4,17b-dihydroxy-17a-methyl-3-oxoandrost-4-ene; 4-hydroxy-17a-methyltestosterone; 17a-methyl-4-androstene-4,17b-diol-...
Literature References: Prepn: GB 848288; Camerino et al., US 3060201 (1960, 1962 to Farmitalia).

Disulfamide CAS Registry Number: 671-88-5 双胺磺氯苯

CAS Name: 4-Chloro-6-methyl-1,3-benzenedisulfonamide
Additional Names: 5-chlorotoluene-2,4-disulfonamide; 2-chloro-4-methylbenzene-1,5-disulfonamide; 5-chloro-2,4-disulfamyltoluene; disulphamid...
Literature References: Prepn: GB 851287 (1960 to Brit. Drug Houses). Pharmacology: David, Fellowes, J. Pharm. Pharmacol. 12, 65 (1960).

Cinoxate CAS Registry Number: 104-28-9 西诺沙酯

CAS Name: 3-(4-Methoxyphenyl)-2-propenoic acid 2-ethoxyethyl ester
Additional Names: p-methoxycinnamic acid 2-ethoxyethyl ester; 2-ethoxyethyl p-methoxycinnamate
Trademarks: Give-Tan (Givaud...
Literature References: Prepn: GB 856411 (1960 to Givaudan).

Cyclobenzaprine CAS Registry Number: 303-53-7 环苯扎林

CAS Name: 3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
Additional Names: N,N-dimethyl-5H-dibenzo[a,d]cyclohepten-D5,g-propylamine; 5-(3-dimethylaminopropylidene)dibenzo[a...
Literature References: Prepn: GB 858187 (1961 to Hoffmann-La Roche); Villani et al., J. Med. Pharm. Chem. 5, 373 (1962); Winthrop et al., J. Org. Chem. 27, 230 (1962). Pharmacology: C. D. Barnes, W. L. Adams, Neuropharmacology 17, 445 (1978); N. N. Share, ibid. 721; and toxicology: J. Metysova et al., Arch. Int. Pharmacodyn. Ther. 144, 481 (1963). Metabolism: G. Belvedere et al., Biomed. Mass Spectrom. 1, 329 (1974); H. B. Hucker et al., Drug Metab. Dispos. 6, 184 (1978). Bioavailability: eidem, J. Clin. Pharmacol. 17, 719 (1977). Clinical studies: J. V. Basmajian, Arch. Phys. Med. Rehabil. 5, 58 (1978); B. R. Brown, J. Womble, J. Am. Med. Assoc. 240, 1151 (1978). Comprehensive description: M. L. Cotton, G. R. B. Down, Anal. Profiles Drug Subs. 17, 41-72 (1988).

Piperacetazine CAS Registry Number: 3819-00-9 乙酰哌普嗪

CAS Name: 1-[10-[3-[4-(2-Hydroxyethyl)-1-piperidinyl]propyl]-10H-phenothiazin-2-yl]ethanone
Additional Names: 10-[3-[4-(2-hydroxyethyl)piperidino]propyl]phenothiazin-2-yl methyl ketone; 2-acety...
Literature References: Prepn: GB 861807 (1961 to Searle). Clinical trial in schizophrenia: R. T. Rada, P. T. Donlon, Curr. Ther. Res. 16, 124 (1974).

Diphemethoxidine CAS Registry Number: 13862-07-2 苯托雷司

CAS Name: 2-(Diphenylmethyl)-1-piperidineethanol
Additional Names: 2-benzhydryl-1-piperidineethanol; 1-(b-hydroxyethyl)-2-(diphenylmethyl)piperidineTrademarks: Cleofil (Ciba)
Percent Composi...
Literature References: Prepn: GB 861815 (1961 to Ciba), C.A. 55, 15517h (1961).

Diisopropylamine Dichloroacetate CAS Registry Number: 660-27-5 二异丙基胺二氯乙酸酯

CAS Name: Dichloroacetic acid compd with N-(1-methylethyl)-2-propanamine (1:1)
Additional Names: dichloroacetic acid diisopropylammonium salt; diisopropylammonium dichloroacetate; diisopropylam...
Literature References: Prepn: GB 862248 (1961 to Italseber). Pharmacology: V. A. E. Kraushaar et al., Arzneim.-Forsch. 13, 109 (1963). Ames mutagenicity test: M. D. Gelernt, V. Herbert, Nutr. Cancer 3, 129 (1982). Pharmacokinetics and TLC determn in racehorses: J.-M. Yang et al., Gen. Pharmacol. 19, 683 (1988). Review of pharmacology: P. W. Stacpoole, J. Clin. Pharmacol. J. New Drugs 9, 282-291 (1969).

Iobenzamic Acid CAS Registry Number: 3115-05-7 碘苯扎酸

CAS Name: N-(3-Amino-2,4,6-triiodobenzoyl)-N-phenyl-b-alanine
Additional Names: b-[N-(3-amino-2,4,6-triiodobenzoyl)phenylamino]propionic acid; isobenzamic acid
Trademarks: Bilibyk (Byk Gulde...
Literature References: Prepn: GB 870321 (1961 to Oesterreichische Stickstoffwerke). Toxicity: Lindner et al., Arzneim.-Forsch. 11, 384 (1961).

Pivalylbenzhydrazine CAS Registry Number: 306-19-4 特戊酰苄基肼

CAS Name: 2,2-Dimethylpropanoic acid 2-(phenylmethyl)hydrazide
Additional Names: pivalic acid 2-benzylhydrazide; N1-pivaloyl-N2-benzylhydrazine; 1-benzyl-2-trimethylacetylhydrazine; 1-benzyl-2-...
Literature References: Prepn: GB 883379 (1961 to Hoffmann-La Roche).