其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Ethamsylate CAS Registry Number: 2624-44-4 酚磺乙胺

CAS Name: 2,5-Dihydroxybenzenesulfonic acid compd with N-ethylethanamine
Additional Names: diethylammonium 2,5-dihydroxybenzenesulfonate; 1-hydroxy-4-oxo-2,5-cyclohexadiene-1-sulfonic acid comp...
Literature References: Prepn: GB 895709 (1962 to Labs. OM); ES 279303 (1962 to Labs. Esteve), C.A. 60, 1652g (1964). Pharmacology: Demars, Med. Exp. 4, 173 (1961); Huguet et al., Therapie 24, 429 (1969). Toxicity: Esteve et al., Therapie 15, 110 (1960).

Clobutinol CAS Registry Number: 14860-49-2 氯丁替诺

CAS Name: 4-Chloro-a-[2-(dimethylamino)-1-methylethyl]-a-methylbenzeneethanol
Additional Names: p-chloro-a-[2-(dimethylamino)-1-methylethyl]-a-methylphenethyl alcohol; 2-(p-chlorobenzyl)-3-dime...
Literature References: Prepn: GB 898010; Berg, US 3121087 (1962, 1964 both to Thomae). Pharmacology: Engelhorn, Arzneim.-Forsch. 10, 785 (1960). Metabolism: Beisenherz et al., ibid. 19, 79 (1969).

Althiazide CAS Registry Number: 5588-16-9 阿尔噻嗪

CAS Name: 6-Chloro-3,4-dihydro-3-[(2-propenylthio)methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 3-[(allylthio)methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiaz...
Literature References: Prepn: GB 902658; W. M. McLamore, G. D. Laubach, US 3111517 (1962, 1963 both to Pfizer). HPLC determn in tablets: F. DeCroo et al., J. Chromatogr. 329, 422 (1985). Clinical evaluation in hypertension: G. Simon et al., Curr. Ther. Res. 46, 44 (1989).

Perimethazine CAS Registry Number: 13093-88-4 哌美他嗪

CAS Name: 1-[3-(2-Methoxy-10H-phenothiazin-10-yl)-2-methylpropyl]-4-piperidinol
Additional Names: 2-methoxy-10-[2-methyl-3-(4-hydroxypiperidino)propyl]phenothiazine; 3-methoxy-10-[3-(4-hydroxyp...
Literature References: Prepn: GB 904210; Jacob, Robert, US 3075976 (1962, 1963 both to Rhône-Poulenc). Pharmacology: L. Julon et al., C.R. Seances Soc. Biol. Ses Fil. 160, 1852 (1966). Clinical evaluation as antipsychotic: M. Bourgeois, A.-M. Sicart, Bordeaux Med. 3, 515 (1970).

Desipramine CAS Registry Number: 50-47-5 盐酸去甲咪嗪

CAS Name: 10,11-Dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine
Additional Names: 10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine; 5-(g-methylaminopropyl)iminodibenzyl; N-(3-...
Literature References: Prepn: GB 908788; BE 614616 (both 1962 to Geigy); J. H. Biel, C. I. Judd, GB 980231 (1965 to Lakeside); eidem, US 3454554 (1969 to Colgate Palmolive). Chemistry, pharmacology: E. Eriksoo, O. Rohte, Arzneim.-Forsch. 20, 1561 (1970). Clinical response, plasma levels, pharmacokinetics: P. D. Hrdina, Y. D. Lapierre, Prog. Neuro-Psychopharmacol. 4, 591 (1980). Mechanism of action study: S. A. Checkley et al., Br. J. Psychiatry 138, 248 (1981). Efficacy in depression: W. Z. Potter et al., Psychopharmacol. Bull. 17, 26 (1981); J. W. Stewart et al., ibid. 136. Teratological study: L. Aeppli, Arzneim.-Forsch. 19, 1617 (1969). Carcinogenicity and mutagenicity study: H. Kubinski et al., Mutat. Res. 89, 95 (1981). Has been found to be one of the most effective cmpds described for in vitro and in vivo reversal of chloroquine, q.v., resistance in Plasmodium falciparum: A. J. Bitonti et al., Science 242, 1301 (1988).

Meturedepa CAS Registry Number: 1661-29-6 美妥替哌

CAS Name: [Bis(2,2-dimethyl-1-aziridinyl)phosphinyl]carbamic acid ethyl ester
Additional Names: ethyl [bis(2,2-dimethyl-1-aziridinyl)phosphinyl]carbamate; ethyl N-[bis(2,2-dimethylethylenimido)...
Literature References: Prepn: GB 911764 (1962 to Armour), C.A. 60, 1701h (1964).

Acetohexamide CAS Registry Number: 968-81-0 醋酸己酰胺

CAS Name: 4-Acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide
Additional Names: 1-[(p-acetylphenyl)sulfonyl]-3-cyclohexylurea; 3-cyclohexyl-1-(p-acetylphenylsulfonyl)urea; N-(p-acetylbenze...
Literature References: Prepn: GB 912789 (1962 to Lilly); Marshall et al., J. Med. Chem. 6, 60 (1963). Comprehensive description: C. E. Shafer, Anal. Profiles Drug Subs. 1, 1-14 (1972); A. A. Al-Badr, H. A. El-Obeid, Anal. Profiles Drug Subs. Excip. 21, 1-41 (1992).

Benproperine CAS Registry Number: 2156-27-6 苯丙哌林

CAS Name: 1-[1-Methyl-2-[2-(phenylmethyl)phenoxy]ethyl]piperidine
Additional Names: 1-[1-methyl-2-[(a-phenyl-o-tolyl)oxy]ethyl]piperidine; 1-[2-(2-benzylphenoxy)-1-methylethyl]piperidine
Per...
Literature References: Prepn: GB 914008; Rubinstein, US 3117059 (1962, 1964 to Aktieselskabet Pharmacia). Pharmacology: Yamatsu et al., Jpn. J. Pharmacol. 17, 538 (1967); N. Tellini, V. De Fina, Boll. Chim. Farm. 109, 476 (1970).

Fluocinonide CAS Registry Number: 356-12-7 醋酸氟轻松

CAS Name: (6a,11b,16a)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
Additional Names: 6a,9-difluoro-11b,16a,17,21-tetrahydroxypregna-1,...
Literature References: Prepn: GB 916996 (1963 to Olin Mathieson), C.A. 59, 1716b (1963); H. J. Ringold, G. Rosenkranz, US 3124571; H. J. Ringold et al., US 3126375 (both 1964 to Syntex); J. Fried, US 3197469 (1965 to Pharm. Res. Prod.). NMR: A. D. Cross, P. W. Landis, J. Am. Chem. Soc. 86, 4005 (1964).

Bisbentiamine CAS Registry Number: 2667-89-2 二苯甲酰二硫化硫胺

CAS Name: N,N'-[Dithiobis[2-[2-(benzoyloxy)ethyl]-1-methyl-2,1-ethenediyl]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamide]
Additional Names: N,N'-[dithiobis[2-(2-hydroxyethyl)-1-methyl...
Literature References: Prepn: GB 922444 (1963 to Tanabe Seiyaku) corresp to US 3109000 (1963); Yurugi et al., Annu. Rep. Takeda Res. Lab. 27, 25 (1968), C.A. 70, 96741m (1968); Imai, Miyaji, DE 1954519 (1971 to Hitachi), C.A. 75, 63821n (1971).