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Perimethazine CAS Registry Number: 13093-88-4 哌美他嗪

CAS Name: 1-[3-(2-Methoxy-10H-phenothiazin-10-yl)-2-methylpropyl]-4-piperidinol
Additional Names: 2-methoxy-10-[2-methyl-3-(4-hydroxypiperidino)propyl]phenothiazine; 3-methoxy-10-[3-(4-hydroxypiperidyl)-2-methylpropyl]phenothiazine; perimetazineTrademarks: Leptryl (Bellon)
Percent Composition: C 68.72%, H 7.34%, N 7.29%, O 8.32%, S 8.34%

📌 参考资料/链接：
Literature References: Prepn: GB 904210; Jacob, Robert, US 3075976 (1962, 1963 both to Rhône-Poulenc). Pharmacology: L. Julon et al., C.R. Seances Soc. Biol. Ses Fil. 160, 1852 (1966). Clinical evaluation as antipsychotic: M. Bourgeois, A.-M. Sicart, Bordeaux Med. 3, 515 (1970).

📄 详细内容

Properties: Crystalline powder from benzene:cyclohexane (15:85), mp 137-138°.
Melting point: mp 137-138°
Derivative Type: Hydrochloride
Percent Composition: C 62.76%, H 6.94%, N 6.65%, O 7.60%, S 7.62%, Cl 8.42%
Properties: LD50 in mice (mg/kg): 115 i.v.; 140 i.p.; 330 s.c.; 310 orally (Julon).
Toxicity data: LD50 in mice (mg/kg): 115 i.v.; 140 i.p.; 330 s.c.; 310 orally (Julon)
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Phenothiazines.
产品链接: 13093-88-4››

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