其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Flurothyl CAS Registry Number: 333-36-8 双(2,2,2-三氟乙基)醚

CAS Name: 1,1'-Oxybis[2,2,2-trifluoroethane]
Additional Names: bis(2,2,2-trifluoroethyl) ether; hexafluorodiethyl ether; bis(trifluoroethyl) ether
Trademarks: Indoklon (Ohio Med.)
Percent...
Literature References: Prepn: GB 814493 (1959 to Pennsalt Chem.); GB 889282 (1962 to Air Reduction). Toxicology in animals: A. Cherkin, Psychopharmacologia 15, 404 (1969). Review of pharmacology: L. Arce, Psychosomatics 11, 358-360 (1970); of clinical trials in psychiatric convulsant therapy: J. G. Small, I. F. Small, Semin. Psychiatry 4, 13-26 (1972).

Thioproperazine CAS Registry Number: 316-81-4 硫丙拉嗪

CAS Name: N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine-2-sulfonamide
Additional Names: 3-dimethylsulfamoyl-10-[3-(4-methylpiperazino)propyl]phenothiazine; 2-dimethylsulfamoyl...
Literature References: Prepn: GB 814512 (1959 to Rhône-Poulenc).

Nicotinic Acid Benzyl Ester CAS Registry Number: 94-44-0 烟酸苄酯

CAS Name: 3-Pyridinecarboxylic acid phenylmethyl ester
Additional Names: pyridine-b-carboxylic acid benzyl ester; benzyl nicotinate
Trademarks: Rubriment (Nordmark); Pycaril; Pykaryl
Perc...
Literature References: Prepn: GB 817103 (1959 to Nordmark-Werke).

Isoaminile CAS Registry Number: 77-51-0 异米尼克

CAS Name: a-[2-(Dimethylamino)propyl]-a-(1-methylethyl)benzeneacetonitrile
Additional Names: 4-(dimethylamino)-2-isopropyl-2-phenylvaleronitrile; 3-cyano-5-dimethylamino-3-phenyl-2-methylhexane...
Literature References: Prepn: GB 822695; Stühmer, Funke, US 2934557 (1959, 1960, both to Kali-Chemie).

Niclosamide CAS Registry Number: 50-65-7 氯硝柳胺

CAS Name: 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Additional Names: 2',5-dichloro-4'-nitrosalicylanilide; 5-chloro-N-(2'-chloro-4'-nitrophenyl)salicylamide; 5-chlorosalicyloyl-(o...
Literature References: Prepn: GB 824345 (1959 to Bayer), C.A. 54, 15822b (1960). See also: E. Schraufstätter, R. Gönnert, US 3079297; R. Strufe et al., US 3113067 (both 1963 to Bayer); Bekhli et al., Med. Prom. SSSR 1965, 25.

Glybuthiazol(e) CAS Registry Number: 535-65-9 4-氨基-N-(5-叔丁基-1,3,4-噻二唑-2-基)苯磺酰胺

CAS Name: 4-Amino-N-[5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide
Additional Names: N1-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfanilamide; sulfatertiobutylthiadiazole; 2-(p-ami...
Literature References: Prepn: GB 828963 (1960 to Rhône-Poulenc).

Chlorprothixene CAS Registry Number: 113-59-7 氯普噻吨

CAS Name: (Z)-3-(2-Chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-1-propanamine
Additional Names: (Z)-2-chloro-N,N-dimethylthioxanthene-D9,g-propylamine; cis-2-chloro-N,N-dimethyl-3-thioxanthen-...
Literature References: Prepn: GB 829763; E. L. Engelhardt, US 3046283 (1960, 1962 both to Merck Co.). Structure-activity study: G. E. Bonvicino et al., J. Org. Chem. 26, 2383 (1961). Comprehensive description: B. C. Rudy, B. Z. Senkowski, Anal. Profiles Drug Subs. 2, 63-84 (1973). HPLC determn in serum: M. Bagli et al., J. Chromatogr. B 657, 141 (1994). Clinical pharmacokinetics: idem et al., Arzneim.-Forsch. 46, 247 (1996).

Phenprobamate CAS Registry Number: 673-31-4 苯丙氨酯

CAS Name: Benzenepropanol carbamate
Additional Names: carbamic acid 3-phenylpropyl ester; 1-carbamoyloxy-3-phenylpropane; g-phenylpropyl carbamate; proformiphenTrademarks: Extacol (Nikken); Spa...
Literature References: Prepn: GB 837718 (1960 to Siegfried AG). Pharmacology: G. Stille, Arzneim.-Forsch. 12, 340 (1962). HPLC determn in plasma: J. X. S. Sun et al., Biopharm. Drug Dispos. 8, 341 (1987). Clinical pharmacokinetics: F. C. Tulunay et al., Arzneim.-Forsch. 48, 1068 (1998).

Tribromsalan CAS Registry Number: 87-10-5 3,5,4'-三溴水杨酰苯胺

CAS Name: 3,5-Dibromo-N-(4-bromophenyl)-2-hydroxybenzamide
Additional Names: 3,4',5-tribromosalicylanilide; TBS
Trademarks: Temasept IV (Hexcel)
Percent Composition: C 34.70%, H 1.79%, Br...
Literature References: Prepn: GB 840366 (1960 to Unilever); Lemaire et al., J. Pharm. Sci. 50, 831 (1961); Lamberti, US 2967885; Schramm, Lemaire, US 3064048; Schramm, US 3057920 (1961, 1962, 1962 all to Lever Bros.); Majewski, US 3254121 (1966 to Dow).

Allylestrenol CAS Registry Number: 432-60-0 烯丙基雌烯醇

CAS Name: (17b)-17-(2-Propenyl)estr-4-en-17-ol
Additional Names: 17-allylestr-4-en-17b-ol; 17a-allyl-17-hydroxy-19-nor-4-androstene; 17-hydroxy-17a-allyl-4-estrene
Trademarks: Gestanin (Orga...
Literature References: Prepn: GB 841411 (1960 to Organon). Determn in pharmaceutical formulations: S. Gorög et al., Analyst 104, 196 (1979). Clinical experience in pregnancy: J. Cortés-Prieto et al., Clin. Ther. 3, 200 (1980).