其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Ipronidazole CAS Registry Number: 14885-29-1 异丙硝唑

CAS Name: 1-Methyl-2-(1-methylethyl)-5-nitro-1H-imidazole
Additional Names: 2-isopropyl-1-methyl-5-nitroimidazoleTrademarks: Ipropran (Roche)
Percent Composition: C 49.70%, H 6.55%, N 24.84%...
Literature References: Prepn: GB 1119636; M. Hoffer, M. Mitrovic, US 3634446 (1968, 1972 both to Hoffmann-La Roche); K. Butler, ZA 6607466 (1968 to Pfizer), C.A. 71, 3384e (1969). Structure-activity relationship: K. Butler et al., J. Med. Chem. 10, 891 (1967). Activity studies as an antihistomonal agent: M. Mitrovic et al., Antimicrob. Agents Chemother. 1968, 445; M. Mitrovic, E. G. Schildknecht, Poult. Sci. 49, 86 (1970); as a growth promotant: W. L. Marusich et al., ibid. 98. Toxicity studies: eidem, ibid. 92.

Oxibendazole CAS Registry Number: 20559-55-1 奥苯达唑

CAS Name: (5-Propoxy-1H-benzimidazol-2-yl)carbamic acid methyl ester
Additional Names: 5-propoxy-2-benzimidazolecarbamic acid methyl ester; 5-propoxy-2-(carbomethoxyamino)benzimidazoleTrademark...
Literature References: Prepn: GB 1123317 corresp to P. P. Actor, J. F. Pagano, US 3574845 (1968, 1971 both to SK F). Comparative anthelmintic effects in mice: C. S. Karunakaron, D. A. Denham, J. Parasitol. 66, 929 (1980). Clinical studies in foals and horses: J. H. Drudge et al., Am. J. Vet. Res. 42, 526 (1981); E. T. Lyons et al., ibid. 685; D. K. Hass et al., ibid. 43, 534 (1982).

Benoxinate CAS Registry Number: 99-43-4 丁氧卡因

CAS Name: 4-Amino-3-butoxybenzoic acid 2-(diethylamino)ethyl ester
Additional Names: 3-butoxy-4-aminobenzoic acid 2-(diethylamino)ethyl ester; 2-(diethylamino)ethyl 4-amino-3-n-butoxybenzoate; ...
Literature References: Prepn: GB 654484 (1951 to Wander).

p-(Benzylsulfonamido)benzoic Acid CAS Registry Number: 536-95-8 4-(苄基磺酰胺基)苯甲酸

CAS Name: 4-[[(Phenylmethyl)sulfonyl]amino]benzoic acid
Additional Names: p-a-toluenesulfonamidobenzoic acid; 4'-carboxyphenylmethanesulfonanilide
Trademarks: Carinamide; Caronamide
Perce...
Literature References: Prepn: GB 666546 (1952 to Sharp Dohme). Toxicity study: Beyer et al., J. Pharmacol. Exp. Ther. 91, 263 (1947).

Cloperastine CAS Registry Number: 3703-76-2 氯哌斯汀

CAS Name: 1-[2-[(4-Chlorophenyl)phenylmethoxy]ethyl]piperidine
Additional Names: 1-[2-[(p-chloro-a-phenylbenzyl)oxy]ethyl]piperidine; p-chlorobenzhydryl 2-(1-piperidyl)ethyl ether
Percent Co...
Literature References: Prepn: GB 670622 (1952 to Parke, Davis); Fujie, Yakugaku Zasshi 81, 693 (1961), C.A. 55, 25848f (1961). Prepn of salts: GB 1179945 (1970 to Yoshitomi Pharm.), C.A. 72, 132549g (1970). Pharmacology: Takagi et al., Yakugaku Zasshi 85, 550 (1965); 87, 907 (1967), C.A. 63, 8932f (1965); 67, 107101u (1967). Metabolism: Kato, Furuta, Oyo Yakuri 5, 735 (1972).

Metabutoxycaine CAS Registry Number: 3624-87-1 美布卡因

CAS Name: 3-Amino-2-butoxybenzoic acid 2-(diethylamino)ethyl ester
Additional Names: 2-butoxy-3-aminobenzoic acid b-diethylaminoethyl ester; b-diethylaminoethyl 2-butoxy-3-aminobenzoate
Perc...
Literature References: Prepn: GB 728527 (1955 to Novocol Chem.), C.A. 50, 5750 (1956).

Bisacodyl CAS Registry Number: 603-50-9 比沙可啶

CAS Name: 4,4'-(2-Pyridylmethylene)bisphenol diacetate
Additional Names: bis(p-acetoxyphenyl)-2-pyridylmethane; (4,4'-diacetoxydiphenyl)(2-pyridyl)methane; 2-(4,4'-diacetoxydiphenylmethyl)pyrid...
Literature References: Prepn: GB 730243; A. Kottler, E. Seeger, US 2764590 (l955, 1956 both to Thomae). Pharmacology and toxicology: Schmidt, Arzneim.-Forsch. 3, 19 (1953). Comparison of efficacy and safety with other stimulant laxatives: A. Wald, J. Clin. Gastroenterol. 36, 386 (2003).

Furazolidone CAS Registry Number: 67-45-8 呋喃唑酮

CAS Name: 3-[[(5-Nitro-2-furanyl)methylene]amino]-2-oxazolidinone
Additional Names: 3-(5-nitrofurfurylideneamino)-2-oxazolidinone; N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidoneTrademarks: F...
Literature References: Prepn: GB 735136; G. Gever, US 2742462; G. D. Drake et al., US 2759931; G. Gever, C. J. O'Keefe, US 2927110 (1955, 1956, 1956, 1960 all to Norwich); G. Gever et al., J. Am. Chem. Soc. 77, 2277 (1955). LC-MS/MS determn of residues in meat: P. Mottier et al., J. Chromatogr. A 1067, 85 (2005). Antimicrobial spectrum and toxicity: J. A. Yurchenco et al., Antibiot. Chemother. 3, 1035 (1953); G. S. Rogers et al., ibid. 6, 231 (1956). Pharmacology and toxicology: B. H. Ali, Vet. Res. Commun. 6, 1 (1983).

Carfimate CAS Registry Number: 3567-38-2 卡非氨酯

CAS Name: a-Ethynylbenzenemethanol carbamate
Additional Names: a-ethynylbenzyl carbamate; carbamic acid a-ethynylbenzyl ester; a-ethynylbenzyl alcohol carbamate; phenylethynylcarbinol carbamate...
Literature References: Prepn: GB 736340 (1955 to Carlo Erba).

Hydroxytetracaine CAS Registry Number: 490-98-2 羟丁卡因

CAS Name: 4-Butylamino-2-hydroxybenzoic acid 2-dimethylaminoethyl ester
Additional Names: p-butylaminosalicylic acid 2-dimethylaminoethyl ester; 2-dimethylaminoethyl p-butylaminosalicylate; hyd...
Literature References: Prepn: GB 736960 (1955); GB 760003 (1956 to Rheinpreussen AG); Grimme, Schmitz, Ber. 84, 734 (1951).