其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Picoperine CAS Registry Number: 21755-66-8 吡哌乙胺

CAS Name: N-Phenyl-N-[2-(1-piperidinyl)ethyl]-2-pyridinemethanamine
Additional Names: 1-[2-[N-(2-pyridylmethyl)anilino]ethyl]piperidine; N-(2-pyridylmethyl)-N-phenyl-N-2-(piperidinoethyl)amine;...
Literature References: Prepn: FR 1511398 and US 3471501 (1968 and 1969 to Takeda); Miyano et al., J. Med. Chem. 13, 704 (1970). Prepn of salts: Sawa et al., Takeda Kenkyushoho 29(2), 275 (1970), C.A. 73, 98758h (1970); Masuda et al., DE 1935172 (1970 to Takeda), C.A. 73, 98818c (1970). Pharmacology: Y. Kasé et al., Arzneim.-Forsch. 19, 1916 (1969); eidem, ibid. 20, 37 (1970). Review: Jpn. Med. Gaz. 8(11), 9 (1971).

Olaquindox CAS Registry Number: 23696-28-8 喹乙醇; 喹酰胺醇

CAS Name: N-(2-Hydroxyethyl)-3-methyl-2-quinoxalinecarboxamide 1,4-dioxideTrademarks: Bay-o-nox (Bayer); Fedan (ICI)
Percent Composition: C 54.75%, H 4.98%, N 15.96%, O 24.31%
Literature References: Prepn: FR 1594628; K. Ley et al., US 3908008 (1970, 1975 to Bayer). Growth promotant activity for pigs: R. S. Barber et al., Anim. Feed Sci. Technol. 4, 117 (1979). HPLC analysis: G. F. Bories, J. Chromatogr. 172, 505 (1979). LC determn in animal feeds: F. J. dos Ramos et al., ibid. 558, 125 (1991).

Alminoprofen CAS Registry Number: 39718-89-3 阿明洛芬

CAS Name: a-Methyl-4-[(2-methyl-2-propenyl)amino]benzeneacetic acid
Additional Names: 2-(p-methylallylaminophenyl)propionic acidTrademarks: Minalfene (Bouchara)
Percent Composition: C 71.21%...
Literature References: Prepn: FR 2137211; E. Bouchera, US 3957850 (1971, 1976 both to Bouchera). Synthesis, pharmacology and toxicity data: B. Dumaitre et al., Eur. J. Med. Chem. 14, 207 (1979). Pharmacokinetic study: A. Premel-Cabic et al., Eur. J. Clin. Pharmacol. 18, 419 (1980).

Mephenytoin CAS Registry Number: 50-12-4 美芬妥因

CAS Name: 5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione
Additional Names: 5-ethyl-3-methyl-5-phenylhydantoin; 3-methyl-5,5-phenylethylhydantoin; methyl hydantoin; phenylethylmethylhydantoin;...
Literature References: Prepn: FR 769667; CH 166004 (both 1934 to Sandoz); CH 179692 (1935 to Sandoz). Pharmacology: I. A. Dzhagatspanyan et al., Pharm. Chem. J. 25, 181 (1991).

N 4 -Sulfanilylsulfanilamide CAS Registry Number: 547-52-4 4-氨基-N-(4-氨磺酰基苯基)苯磺酰胺

CAS Name: 4'-Sulfamoylsulfanilanilide
Additional Names: 4-aminobenzenesulfono-p-sulfamoylanilide; 4-(4'-aminobenzenesulfonamido)benzenesulfonamideTrademarks: Diseptal C; Uliron C; Disulon (Spec...
Literature References: Prepn: FR 817034 (to I. G. Farben.), C.A. 32, 1714i (1938); Sakai, Yamamoto, J. Pharm. Soc. Jpn. 58, 683 (1938); Golovchinskaya, J. Appl. Chem. USSR 18, 647 (1945); Sasa, J. Soc. Org. Syn. Chem. Jpn. 12, 211 (1954), C.A. 51, 2780h (1957); Grigorovskii, Dykhanov, J. Appl. Chem. USSR 30, 1284 (1957).

Dapsone CAS Registry Number: 80-08-0 4,4'-二氨基二苯砜

CAS Name: 4,4'-Sulfonylbisbenzeneamine
Additional Names: 4,4'-sulfonyldianiline; bis(4-aminophenyl)sulfone; 4,4'-diaminodiphenyl sulfone; DDS; diaphenylsulfone; DADPSTrademarks: Avlosulfon (Wye...
Literature References: Prepn: FR 829926 (1938 to I. G. Farbenind.), C.A. 33, 1761 (1939); Buckles, J. Chem. Educ. 31, 36 (1954); Ferry et al., Org. Synth. coll. vol. III, 239 (1955). Antibacterial action and metabolism: J. Francis, A. Spinks, Br. J. Pharmacol. 5, 565 (1950). Mechanism of toxic action: Wu, DuBois, Arch. Int. Pharmacodyn. Ther. 183, 36 (1970). Comprehensive description: C. E. Orzech et al., Anal. Profiles Drug Subs. 5, 87-114 (1976). Review of pharmacology and therapeutic use: J. Uetrecht, Clin. Dermatol. 7, 111-120 (1989). Clinical trial with chlorproguanil, q.v., in drug-resistant malaria: T. Mutabingwa et al., Lancet 358, 1218 (2001).

Heptabarbital CAS Registry Number: 509-86-4 环庚比妥

CAS Name: 5-(1-Cyclohepten-1-yl)-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-(1-cyclohepten-1-yl)-5-ethylbarbituric acid; 5-ethyl-5-cycloheptenylbarbituric acid; heptabarb
T...
Literature References: Prepn: FR 870714 (1942 to Geigy); Taub, US 2501551 (1950).

Sulfisomidine CAS Registry Number: 515-64-0 磺胺索嘧啶

CAS Name: 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide
Additional Names: N1-(2,6-dimethyl-4-pyrimidinyl)sulfanilamide; 2,6-dimethyl-4-sulfanilamidopyrimidine; 6-sulfanilamido-2,4-di...
Literature References: Prepn: FR 886009 (1943 to Nordmark); Gysin, US 2351333 (1944 to Geigy); Hartmann et al., US 2386852; US 2429184 (1945, 1947, both to Ciba); Matsukawa et al., J. Pharm. Soc. Jpn. 70, 283 (1950); Loop, Lührs, Ann. 580, 225 (1953).

Carbubarb CAS Registry Number: 960-05-4 卡布比妥

CAS Name: 5-[2-[(Aminocarbonyl)oxy]ethyl]-5-butyl-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: carbamic acid ester with 5-butyl-5-(2-hydroxyethyl)barbituric acid; 5-butyl-5-carbamoyloxyet...
Literature References: Prepn: FR M1059 (1962 to Consortium Mondial des Grandes Marques), C.A. 59, 7539c (1963); Buzas, US 3150137 (1964). Purification and toxicity: FR M2633 (1964 to Interco Fribourg), C.A. 62, 1671e (1965).

Niceritrol CAS Registry Number: 5868-05-3 烟酸戊四醇酯

CAS Name: 3-Pyridinecarboxylic acid 2,2-bis[[(3-pyridinylcarbonyl)oxy]methyl]-1,3-propanediyl ester
Additional Names: nicotinic acid neopentanetetrayl ester; pentaerythritol tetranicotinateTrad...
Literature References: Prepn: FR M2046 (1963 to Soc. d'Etudes et de Recherches Pharmacotechniques), C.A. 60, 10656e (1964); GB 1022880; GB 1053689 (1966, 1967 to Aktiebolag Bofors), C.A. 64, 19708d (1966), C.A. 66, 104907e (1967); Kuriyama, Kudo, JP 67 2359 (1967 to Yoshitomi), C.A. 66, 115935p (1967). Acute toxicity data: T. Sugawara et al., Oyo Yakuri 14, 741 (1977), C.A. 88, 131005v (1977).