其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Cycothiamin(e) CAS Registry Number: 6092-18-8 噻内脂硫胺

CAS Name: N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[1-(2-oxo-1,3-oxathian-4-ylidene)ethyl]formamide
Additional Names: carbothiamine; cyclocarbothiamine; cycotiamine; CCT
Trademarks: Come...
Literature References: Prepn: NL 6511842 corresp. to Murakami et al., US 3324124 (1966, 1967 to Yamanouchi Seiyaku).

Pramiverin CAS Registry Number: 14334-40-8 N-(1-甲基乙基)-4,4-二苯基-环己胺

CAS Name: N-(1-Methylethyl)-4,4-diphenylcyclohexanamine
Additional Names: N-isopropyl-4,4-diphenylcyclohexylamine; pramiverine; primaverine; propaminodiphen
Percent Composition: C 85.95%, H ...
Literature References: Prepn: NL 6515046; R. Unger et al., US 3376312 (1966, 1968 both to E. Merck). Pharmacology: H. J. Enenkel et al., Arzneim.-Forsch. 26, 690 (1976). Toxicological study: M. Von Eberstein et al., ibid., 703. Series of articles on pharmacology, pharmacokinetics, GC determn, clinical studies: ibid., 686-752. Use in management of labor: G. LoDico et al., Minerva Ginecol. 31, 683 (1979).

Iocetamic Acid CAS Registry Number: 16034-77-8 碘西他酸

CAS Name: 3-[Acetyl-(3-amino-2,4,6-triiodophenyl)amino]-2-methylpropanoic acid
Additional Names: N-acetyl-N-(3-amino-2,4,6-triiodophenyl)-2-methyl-b-alanine; N-acetyl-N-(2,4,6-triiodo-3-aminoph...
Literature References: Prepn: NL 6515305; NL 6607275 (both 1967 to Dagra), C.A. 67, 108422m (1967); 69, 10263b (1968); Korver, Rec. Trav. Chim. 87, 308 (1968). Pharmacology and toxicology: J. M. Janbroers et al., Toxicol. Appl. Pharmacol. 14, 232, 246 (1969). Metabolic studies: Neleman, Pharm. Weekbl. 102, 1039 (1967). Clinical studies: Hekster, Radiol. Clin. Biol. 37, 338 (1968). Use in cholecystography: B. Goldberg, Radiol. Clin. 46, 42 (1977).

Nitroxynil CAS Registry Number: 1689-89-0 硝碘酚腈

CAS Name: 4-Hydroxy-3-iodo-5-nitrobenzonitrile
Trademarks: Dovenix (Specia)
Percent Composition: C 28.99%, H 1.04%, I 43.76%, N 9.66%, O 16.55%
Literature References: Prepn: NL 6516359 corresp to Collins et al., US 3331738 (1966, 1967 both to May Baker).

Demegestone CAS Registry Number: 10116-22-0 地美孕酮

CAS Name: 17-Methyl-19-norpregna-4,9-diene-3,20-dione
Additional Names: 17a-methyl-19-nor-D4,9-pregnadiene-3,20-dione; 17a-methyl-D9-19-norprogesteroneTrademarks: Lutionex (Roussel Diamant)
...
Literature References: Prepn: NL 6517141; R. Joly et al., US 3547959 (1966, 1970 both to Roussel-UCLAF); L. Velluz et al., Tetrahedron Suppl. 8, part II, 495 (1966); R. Joly et al., Bull. Soc. Chim. Fr. 1973, 2694.

Simfibrate CAS Registry Number: 14929-11-4 酯丙二醇

CAS Name: 2-(4-Chlorophenoxy)-2-methylpropanoic acid 1,3-propanediyl ester
Additional Names: 2-(p-chlorophenoxy)-2-methylpropionic acid trimethylene ester; 1,3-propanediol bis[a-(p-chlorophenox...
Literature References: Prepn: NL 6600044 corresp to Nakanishi et al., US 3494957 (1966, 1970 to Yoshitomi). Activity and toxicology studies: Nakanishi et al., J. Pharm. Soc. Jpn. 90, 267, 921, 926 (1970). Activity on postheparin lipoprotein lipase: L. Cavallini et al., Clin. Ter. 92, 25 (1980).

Propizepine CAS Registry Number: 10321-12-7 丙吡西平

CAS Name: 6-[2-(Dimethylamino)propyl]-1,6-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one
Additional Names: 6,11-dihydro-6-[2-(dimethylamino)-2-methylethyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-...
Literature References: Prepn: NL 6600065 (1966 to Labs. U.P.S.A.); Hoffmann, Faure, Bull. Soc. Chim. Fr. 1966, 2316. Psychopharmacology: Lwoff et al., Therapie 26, 451 (1971).

Pimefylline CAS Registry Number: 10001-43-1 匹美茶碱

CAS Name: 3,7-Dihydro-1,3-dimethyl-7-[2-[(3-pyridinylmethyl)amino]ethyl]-1H-purine-2,6-dione
Additional Names: 7-[2-[(3-pyridylmethyl)amino]ethyl]theophylline; 7-(b-3'-picolylaminoethyl)theophy...
Literature References: Prepn: NL 6600250; Suter, Zutter, US 3350400 (1966, 1967 both to Eprova). Structure determn, properties and chemistry: eidem, Pharm. Acta Helv. 48, 133 (1973). Pharmacology: Ciaceri, Attaguile, Gazz. Med. Ital. 132, 36, 108 (1973). Metabolism: Pitrè, Farmaco Ed. Prat. 29, 46 (1974).

Diclofenac CAS Registry Number: 15307-86-5 双氯芬酸

CAS Name: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid
Additional Names: [o-(2,6-dichloroanilino)phenyl]acetic acid
Trademarks: Motifene (Sankyo)
Percent Composition: C 56.78%, H 3.74%...
Literature References: Prepn: NL 6604752; A. Sallmann, R. Pfister, US 3558690 (1966, 1971 both to Geigy). Pharmacology: Renaud, Lecompte, Thromb. Diath. Haemorrh. 24, 577 (1970), C.A. 74, 86215m (1971); Krupp et al., Experientia 29, 450 (1973). HPLC determn in plasma and urine: J. Godbillon et al., J. Chromatogr. 338, 151 (1985). Symposium on pharmacology and clinical experience: Semin. Arthritis Rheum. 15, Suppl. 1, 57-110 (1985); on pharmacology, efficacy and safety: Am. J. Med. 80, Suppl. 4B, 1-87 (1986). Comprehensive description: C. M. Adeyeye, P-K. Li, Anal. Profiles Drug Subs. 19, 123-144 (1990). Review of clinical trials in actinic keratosis: D. C. Peters, R. H. Foster, Drugs Aging 14, 313-319 (1999).

Decimemide CAS Registry Number: 14817-09-5 地西酰胺

CAS Name: 4-(Decyloxy)-3,5-dimethoxybenzamideTrademarks: Denegyt
Percent Composition: C 67.63%, H 9.26%, N 4.15%, O 18.97%
Literature References: Prepn: NL 6605460; E. Kasztreiner et al., US 3432549 (1966, 1969 both to EGYT). Pharmacology: E. Kasztreiner, Magy. Kem. Lapja 27, 370 (1972), C.A. 78, 66697z (1973); I. Kiraly et al., Acta Physiol. Acad. Sci. Hung. 47, 200 (1976). Metabolism study: G. Molnar et al., Acta Pharm. Hung. 48, Suppl., 58 (1978). Toxicity data: E. Usdin, D. H. Efron, Eds., Psychotropic Drugs and Related Compounds (NIH, Washington, D. C., 2nd Ed., 1972) p 377.