其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Piroheptine CAS Registry Number: 16378-21-5 吡咯庚汀

CAS Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-ethyl-2-methylpyrrolidine
Percent Composition: C 87.08%, H 8.30%, N 4.62%
Literature References: Prepn: NL 6609280; Y. Deguchi et al., US 3454595 (1967, 1969 both to Fujisawa). Crystal structure: Y. Tokuma et al., Bull. Chem. Soc. Jpn. 44, 2665 (1971). Pharmacological studies: M. Hitomi et al., Arzneim.-Forsch. 22, 953, 961 (1972). In vitro study: T. Ohashi et al., ibid. 966. Metabolism: Y. Tokuma et al., Bull. Chem. Soc. Jpn. 48, 294 (1975). Clinical pharmacology: A. Barbeau, Annu. Rev. Pharmacol. 14, 91 (1974). Toxicity study: M. Hitomi et al., Arzneim.-Forsch. 22, 961 (1972).

Nicofibrate CAS Registry Number: 31980-29-7 尼可贝特

CAS Name: 2-(4-Chlorophenoxy)-2-methylpropanoic acid 3-pyridinylmethyl ester
Additional Names: 2-(p-chlorophenoxy)-2-methylpropionic acid 3-pyridylmethyl ester; 3-hydroxymethylpyridine p-chloro...
Literature References: Prepn: NL 6610738 corresp to Bolhofer, US 3369025 (1967, 1968, both to Merck Co.); Nakanishi et al., JP 68 14466 (1968 to Yoshitomi); Garzia, DE 1948320 (1970 to Ist. Chem. Ital.). Pharmacology: Marmo et al., Farmaco Ed. Prat. 26, 557 (1971).

Sulfacytine CAS Registry Number: 17784-12-2 4-氨基-N-(1-乙基-2-氧代-1,2-二氢嘧啶-4-基)苯磺酰胺

CAS Name: 4-Amino-N-(1-ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)benzenesulfonamide
Additional Names: N'-(1-ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)sulfanilamide; 1-ethyl-N-sulfanilylcytosine; N-sulf...
Literature References: Prepn: NL 6610815 corresp to Doub, Krolls, US 3375247 (1967, 1968 to Parke, Davis). Prepn and activity: Doub et al., J. Med. Chem. 13, 242 (1970).

Minoxidil CAS Registry Number: 38304-91-5 米诺地尔

CAS Name: 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide
Additional Names: 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine; 2,3-dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrim...
Literature References: Prepn: NL 6615385; W. C. Anthony et al., US 3382247 (1967, 1968 both to Upjohn); J. M. McCall et al., J. Org. Chem. 40, 3304 (1975). See also W. C. Anthony, US 3644364 (1972 to Upjohn). Metabolism: R. C. Thomas et al., J. Pharm. Sci. 64, 1360 (1975). Pharmacology and pharmacokinetics: D. T. Lowenthal et al., J. Clin. Pharmacol. 18, 500 (1978). Percutaneous absorption and excretion: T. J. Franz, Arch. Dermatol. 121, 203 (1985). Clinical studies: O. Andersson, R. Sivertsson, Acta Med. Scand. 205, 213 (1979); M. Moser, Adv. Cardiol. 26, 38 (1979). Clinical trial in early male pattern baldness: E. A. Olsen et al., J. Am. Acad. Dermatol. 13, 185 (1985). Toxicology: R. G. Carlson, E. S. Feenstra, Toxicol. Appl. Pharmacol. 39, 1 (1977). Review of pharmacology and therapeutic use: V. M. Campese, Drugs 22, 257-278 (1981). Review of topical application in baldness: E. Novak et al., Int. J. Dermatol. 24, 82 (1985). Comprehensive description: D. K. J. Gorecki, Anal. Profiles Drug Subs. 17, 185-219 (1988).

Rafoxanide CAS Registry Number: 22662-39-1 雷复尼特

CAS Name: N-[3-Chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide
Additional Names: 3'-chloro-4'-(p-chlorophenoxy)-3,5-diiodosalicylanilideTrademarks: Flukanide (Merck Co.); Ranid...
Literature References: Prepn: NL 6815783; BE 724668 (both 1969 to Merck Co.); Mrozik et al., Experientia 25, 883 (1969). Trials in sheep and cattle: Snijders, Horak, Louw, J. S. Afr. Vet. Med. Assoc. 43, 397 (1972); 44, 251 (1973); 46, 265 (1975); Horak, Snijders, Vet. Rec. 94, 12 (1974).

Rimexolone CAS Registry Number: 49697-38-3 瑞美松龙

CAS Name: (11b,16a,17b)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one
Additional Names: 11b-hydroxy-16a,17a-dimethyl-17-propionylandrosta-1,4-dien-3-one; 11b-hydroxy-16a,17a...
Literature References: Prepn: NL 7300313; G. F. Woods et al., US 3947478 (1973, 1976 both to Akzo); J. Cairns et al., J. Chem. Soc. Perkin Trans. 1 1981, 2306. Pharmacology: P. K. Fox et al., Arzneim.-Forsch. 30, 55 (1980). Clinical trial in rheumatoid arthritis: E. van Vliet-Daskalopoulou et al., Br. J. Rheumatol. 26, 450 (1987). Clinical pharmacokinetics: G. Gevers et al., Clin. Rheumatol. 13, 103 (1994).

Sulbenox CAS Registry Number: 58095-31-1 舒贝诺司

CAS Name: (4,5,6,7-Tetrahydro-7-oxobenzo[b]thien-4-yl)ureaTrademarks: Vigazoo (Am. Cyanamid)
Percent Composition: C 51.41%, H 4.79%, N 13.32%, O 15.22%, S 15.25%
Literature References: Prepn: NL 7610270 (1977 to Am. Cyanamid), C.A. 88, 22607x (1978). Activity: G. Asato, R. D. Wilbur, Experientia 35, 1458 (1979).

Itramin Tosylate CAS Registry Number: 13445-63-1 2-氨基-乙醇硝酸酯对甲苯磺酸盐

CAS Name: 2-Aminoethanol nitrate mono(4-methylbenzenesulfonate)
Additional Names: 2-aminoethanol nitrate mono-p-toluenesulfonate; 2-nitratoethylaminotoluene-p-sulfonate
Trademarks: Cardisan;...
Literature References: Prepn: SE 168308 (1959 to Aktiebolaget Pharmacia), C.A. 54, 24405d (1960).

Aprobarbital CAS Registry Number: 77-02-1 烯丙异丙巴比妥

CAS Name: 5-(1-Methylethyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-allyl-5-isopropylbarbituric acid; allypropymal
Trademarks: Alurate (Roche)
Percent Composit...
Literature References: Prepn: US 1444802 (1923). Toxicity data: H. H. Frey, Arzneim.-Forsch. 12, 389 (1962).

Propallylonal CAS Registry Number: 545-93-7 丙溴比妥

CAS Name: 5-(2-Bromo-2-propenyl)-5-(1-methylethyl)-2,4,6(1H,3H,5H)pyrimidinetrione
Additional Names: 5-(2-bromoallyl)-5-isopropylbarbituric acid
Trademarks: Noctal (UCB)
Percent Compositi...
Literature References: Prepn: US 1622129 (1927); cf. Herzog, Arch. Pharm. 263, 216 (1925). Acute toxicity: Maloney, J. Pharmacol. Exp. Ther. 42, 267 (1931).