其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Exiproben CAS Registry Number: 26281-69-6 2-(2-羟基-3-己基氧基丙氧基)苯甲酸

CAS Name: 2-[3-(Hexyloxy)-2-hydroxypropoxy]benzoic acid
Percent Composition: C 64.84%, H 8.16%, O 26.99%
Literature References: Prepn: GB 933980 (1963 to Thomae), C.A. 60, 2866a (1964); G. Ohnacher, US 3198827 (1965 to Boehringer, Ing.). Metabolism study: A. Pinelli, Pharmacol. Res. Commun. 5, 17 (1973). Choleretic activity: R. Bossa et al., Fegato 17, 21 (1971), C.A. 76, 135808j (1972). Clinical study: N. D'Imperio et al., Clin. Ter. 78, 153 (1976).

Clemastine CAS Registry Number: 15686-51-8 氯马斯汀

CAS Name: (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine
Additional Names: (+)-2-[2-[(p-chloro-a-methyl-a-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine; 1-methyl-2-[...
Literature References: Prepn: GB 942152 (1963 to Sandoz). Synthesis and abs config: A. Ebnöther, H. P. Weber, Helv. Chim. Acta 59, 2462 (1976). Pharmacology and toxicology of the hydrogen fumarate: Weidmann et al., Boll. Chim. Farm. 106, 467 (1967). HPLC determn in plasma: V. Horváth et al., J. Chromatogr. B 816, 153 (2005).

Inaperisone CAS Registry Number: 99323-21-4 依那立松

CAS Name: 1-(4-Ethylphenyl)-2-methyl-3-(1-pyrrolidinyl)-1-propanone
Additional Names: (±)-4'-ethyl-2-methyl-3-(1-pyrrolidinyl)propiophenone
Percent Composition: C 78.32%, H 9.45%, N 5.7...
Literature References: Prepn: JP Kokai 84 33276; Y. Itho et al., US 4638009 (1984, 1987 both to Hokuriku). Pharmacology: K. Morikawa et al., Arzneim.-Forsch. 37, 331 (1987); idem et al., Eur. J. Pharmacol. 213, 409 (1992). Pharmacokinetics in rats: O. Nagata et al., Drug Metab. Dispos. 18, 902 (1990). GC/MS determn in human serum: idem et al., J. Chromatogr. 496, 456 (1989). Series of articles on toxicology: Yakuri to Chiryo 20, 1027-1115 (1992). Comparative clinical evaluation: K. Hiraga et al., Rinsho Yakuri 23, 635 (1992), C.A. 118, 247431y (1993).

Furazolium Chloride CAS Registry Number: 5118-17-2 呋唑氯铵

CAS Name: 6,7-Dihydro-3-(5-nitro-2-furanyl)-5H-imidazo[2,1-b]thiazol-4-ium chlorideTrademarks: Dermafur (Eaton)
Percent Composition: C 39.49%, H 2.95%, Cl 12.95%, N 15.35%, O 17.54%, S 11.72%
Literature References: Prepn: NL 6400380; H. R. Snyder, Jr., US 3169970 (1964, 1965, both to Norwich Pharmacal); H. R. Snyder, Jr., L. E. Benjamin, J. Med. Chem. 9, 402 (1966).

Norgestrienone CAS Registry Number: 848-21-5 诺孕烯酮

CAS Name: (17a)-17-Hydroxy-19-norpregna-4,9,11-trien-20-yn-3-one
Additional Names: 17a-ethynyl-4,9,11-estratrien-17b-ol-3-one; 17a-ethynyl-17b-hydroxy-3-oxo-4,9,11-estratriene; 17a-ethynyl-13b-...
Literature References: Prepn: NL 6401555, corresp to Nominé et al., US 3257278 (1964 and 1966, both to Roussel-UCLAF); Nominé et al., Compt. Rend. 260, 4545 (1965); FR M3060 and NL 6517141 (1965 and 1966, both to Roussel-UCLAF), C.A. 63, 8449b (1965) and 65, 15470b (1966).

Bumadizon CAS Registry Number: 3583-64-0 布马地宗

CAS Name: Butylpropanedioic acid mono(1,2-diphenylhydrazide)
Additional Names: butylmalonic acid mono(1,2-diphenylhydrazide); N-(2-carboxycaproyl)hydrazobenzene; a-carboxycaproyl-N,N'-diphenylh...
Literature References: Prepn: NL 6406412; Pfister et al., US 3455999 (1964, 1969 to Geigy); NL 6600685 (1966 to Byk-Gulden). Main product of the hydrolysis of phenylbutazone, q.v.: Schmid, Helv. Chim. Acta 53, 2239 (1970). Chemical characterization: Pawelczyk, Wachowiak, Acta Pol. Pharm. 26, 433 (1969), C.A. 72, 136355p (1970). Series of articles on pharmacology: Arzneim.-Forsch. 23, 1226-1251, 1813-1822 (1973). Toxicity: R. Riedel, W. Schoetensack, ibid. 1215.

Perisoxal CAS Registry Number: 2055-44-9 哌立索唑

CAS Name: a-(5-Phenyl-3-isoxazolyl)-1-piperidineethanol
Additional Names: 3-(2-piperidino-1-hydroxyethyl)-5-phenylisoxazole
Percent Composition: C 70.56%, H 7.40%, N 10.29%, O 11.75%
Literature References: Prepn: NL 6408694; H. Kano et al., US 3321475 (1965, 1967 both to Shionogi); eidem, J. Med. Chem. 10, 411 (1967). Series of articles on pharmacological properties: Oyo Yakuri 6, 1285-1338 (1972), C.A. 79, 49177h-49179k (1973). Studies on physical dependence in rats: K. Yamamoto et al., ibid. 16, 871 (1978), C.A. 90, 180250w (1979). Absorption, excretion, distribution, metabolism: J. Watanabe et al., Chem. Pharm. Bull. 27, 1075 (1979). Toxicity study: H. Kano et al., J. Med. Chem. 10, 411 (1967).

Oxyclozanide CAS Registry Number: 2277-92-1 五氯柳胺

CAS Name: 2,3,5-Trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide
Additional Names: 3,3',5,5',6-pentachloro-2'-hydroxysalicylanilide; 3,3',5,5',6-pentachloro-2,2'-dihydroxybenzanili...
Literature References: Prepn: NL 6409325 corresp to Broome et al., US 3349090 (1965, 1967, both to I.C.I.).

Clocortolone CAS Registry Number: 4828-27-7 氯可托龙

CAS Name: (6a,11b,16a)-9-Chloro-6-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Additional Names: 9-chloro-6a-fluoro-16a-methyl-1,4-pregnadiene-11b,21-diol-3,20-dione
Percent C...
Literature References: Prepn: NL 6412708; E. K. Kaspar, R. Philippson, DE 2011559; eidem, US 3729495 (1965, 1971, 1973 all to Schering AG). Clinical trials: Wortmann, Wien. Med. Wochenschr. 122, 701 (1972); Baumann, Praxis 61, 536 (1972).

Bromofenofos CAS Registry Number: 21466-07-9 溴酚磷酸一水合物

CAS Name: 3,3',5,5'-Tetrabromo-(1,1'-biphenyl)-2,2'-diol mono(dihydrogen phosphate)
Additional Names: 3,3',5,5'-tetrabromo-2,2'-biphenyldiol mono(dihydrogen phosphate); 4,4',6,6'-tetrabromobiph...
Literature References: Prepn: NL 6505635; S. Van der Meer et al., US 3662035 (1966, 1972 both to Chemiefarma); S. Van der Meer, H. Pouwels, J. Med. Chem. 12, 534 (1969). Activity: J. Guilhon et al., Bull. Acad. Vet. Fr. 43, 67 (1970). Toxicology: J. M. Poul, M. Dagorn, Recl. Med. Vet. 158, 363 (1982).