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Bumadizon CAS Registry Number: 3583-64-0 布马地宗

CAS Name: Butylpropanedioic acid mono(1,2-diphenylhydrazide)
Additional Names: butylmalonic acid mono(1,2-diphenylhydrazide); N-(2-carboxycaproyl)hydrazobenzene; a-carboxycaproyl-N,N'-diphenylhydrazine
Percent Composition: C 69.92%, H 6.79%, N 8.58%, O 14.71%

📌 参考资料/链接：
Literature References: Prepn: NL 6406412; Pfister et al., US 3455999 (1964, 1969 to Geigy); NL 6600685 (1966 to Byk-Gulden). Main product of the hydrolysis of phenylbutazone, q.v.: Schmid, Helv. Chim. Acta 53, 2239 (1970). Chemical characterization: Pawelczyk, Wachowiak, Acta Pol. Pharm. 26, 433 (1969), C.A. 72, 136355p (1970). Series of articles on pharmacology: Arzneim.-Forsch. 23, 1226-1251, 1813-1822 (1973). Toxicity: R. Riedel, W. Schoetensack, ibid. 1215.

📄 详细内容

Properties: Crystals from ether-petr ether, mp 116-117°. Also reported as mp 77-79° (dependent on speed of crystallization). uv max (0.1N NaOH): 234, 264 nm (e 16200, 3700).
Melting point: mp 116-117°; mp 77-79° (dependent on speed of crystallization)
Absorption maximum: uv max (0.1N NaOH): 234, 264 nm (e 16200, 3700)
Derivative Type: Calcium salt hemihydrate
CAS Registry Number: 69365-73-7
Trademarks: Bumaflex (Byk-Liprandi); Eumotol (Byk Gulden); Rheumatol (Tosse)
Percent Composition: C 65.21%, H 6.19%, Ca 5.73%, N 8.01%, O 14.86%
Properties: Dec 154°. Sol in chloroform, alcohol, ether. Slightly sol in water. LD50 in mice, rats (mg/kg): 2500, 1250 orally; 258, 263 i.v. (Riedel, Schoetensack).
Toxicity data: LD50 in mice, rats (mg/kg): 2500, 1250 orally; 258, 263 i.v. (Riedel, Schoetensack)
Therap-Cat: Analgesic; antipyretic; anti-inflammatory.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Arylbutyric Acid Derivatives; Antipyretic.
产品链接: 3583-64-0››

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