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Aripiprazole CAS# 129722-12-9 阿立哌唑
Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. It is recommended and primarily used in the treatment of schizophrenia and bipolar disorder. Other uses incl...
Shi, Hang; Babinski, David J.; Ritter, Tobias. Modular C-H Functionalization Cascade of Aryl Iodides. Journal of the American Chemical Society. Volume 137. Issue 11. Pages 3775-3778. 2015.
Darolutamide CAS# 1297538-32-9 达若鲁胺
ODM-201, also known as Darolutamide, is a new-generation, potent and selective androgen receptor (AR) inhibitor which is potential useful for treatment of castration-resistant prostate cancer (CRPC). ...
Reference: Pan, Tingting; Xia, Chunguang; Yang, Yulei; Zhang, Aiming. Process and intermediates for preparation of androgen receptor antagonist. Assignee Lianyungang Runzhong Pharmaceutical Co., Ltd., Peop. Rep. China; Shanghai Institute of Pharmaceutical Industry. CN 108218908. (2018).
Ozanimod CAS# 1306760-87-1 奥扎莫德
Ozanimod (RPC‑1063) is a highly potent and selective S1P₁ and S1P₅ receptor agonist, with EC₅₀ values of ~1 nM for S1P₁ and ~8–11 nM for S1P₅ in human and animal receptor assays. It induces sustained ...
Enantioselective Synthesis of Ozanimod, the Active Pharmaceutical Ingredient of a New Drug for Multiple SclerosisBy: Cianferotti, Claudio; et alEuropean Journal of Organic Chemistry (2021), 2021(12), 1924-1930
Upadacitinib CAS# 1310726-60-3 乌帕替尼
Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays ...
Reference: Pangan, Aileen L.; Teixeira, Henrique D.; Allian, Ayman D.; Borchardt, Thomas B.; Jayanth, Jayanthy; Marroum, Patrick J.; Nordstrom, Fredrik Lars; Sheikh, Ahmad Y.; Mohamed, Mohamed-Eslam F.; Othman, Ahmed A.; Mayer, Peter T. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof for disease treatment. Assignee AbbVie Inc., USA. US 20180298016. (2018).
Xanomeline CAS# 131986-45-3 占诺美林
Xanomeline is a muscarinic acetylcholine receptor agonist with functional selectivity for M1 and M4 receptors. Xanomeline exhibits high affinity for the M1 and M4 muscarinic receptors, leading to cogn...
Novel Xanomeline-Containing Bitopic Ligands of Muscarinic Acetylcholine Receptors: Design, Synthesis and FRET InvestigationBy: Matera, Carlo; et alMolecules (2023), 28(5), 2407
Vamorolone CAS# 13209-41-1 (8S,10S,13S,14S,16R,17R)-17-羟基-17-(2-羟基乙酰基)-10,13,16-三甲基-6,7,8,10,12,13,14,15,16,17-十氢-3H-环戊并[a]菲-3-酮(地塞米松杂质)
Vamorolone is a dissociative steroid designed to retain anti-inflammatory activity while minimizing the side effects associated with classical glucocorticoids. In vitro, it binds the glucocorticoid re...
Intermediates in the preparation of (10S,13S,16R,17R)-17-hydroxy17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[A]phenanthren-3-oneBy: AnonymousIP.com Journal (2025), 25(3A), 1-7
Darifenacin Hydrobromide CAS# 133099-07-7 氢溴酸达非那新
Darifenacin, also known as UK-88525, is a medication used to treat urinary incontinence. Darifenacin works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for blad...
Gao, Juan; Zang, Hengchang. Synthesis method of darifenacin hydrobromide. Qilu Yaoshi. School of Pharmaceutical Sciences. Shandong University. Jinan, Shandong Province, Peop. Rep. China 255012. Volume 31. Issue 2. Pages 68-69, 77. 2012
Landiolol CAS# 133242-30-5 兰地洛尔
Landiolol, also known as LDLL600 and ONO 1101, is an ultra-short-acting β1-blocker. Landiolol is a highly selective beta-1-adrenoreceptor antagonist (the selectivity for beta-1-receptor blockade is 25...
Development of a highly cardioselective ultra short-acting β-blocker, ONO-1101By: Iguchi, Sadahiko; et alChemical & Pharmaceutical Bulletin (1992), 40(6), 1462-9
Iloperidone CAS# 133454-47-4 伊潘立酮
Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms.
Process for preparing iloperidone and its salts; Dwivedi, Shriprakash Dhar; Patel, Dhimant Jasubhai; Shah, Alpesh Pravinchandra; Assignee Cadila Healthcare Limited, India; 2013; Patent Information; Jun 28, 2013; IN 2010MU03103 A
Zavegepant CAS# 1337918-83-8 4-(1,2-二氢-2-氧-3-喹啉)-N-((1R)-1-((7-甲基-1H-吭唑-5-基)甲基)-2-(4-(1-甲基-4-哌啶啶)-1-哌嗪酰)-2-氧乙基)-1-哌啶羧酰胺
Zavegepant, also known as Vazegepant, BHV-3500 and BMS 742413, is a highly potent, selective and structurally unique small molecule CGRP receptor antagonist. Vazegepant is the first and only CGRP rec...
Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal deliveryBy: Chaturvedula, Prasad V.; et alBioorganic & Medicinal Chemistry Letters (2013), 23(11), 3157-3161
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