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Larotrectinib CAS# 1223403-58-4 拉罗替尼
Larotrectinib, also known as ARRY-470 and LOXO-101, is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC. LOXO-101 has IC50 values in the low nanomolar range for inhibi...
Reference: Ji, Min; Liu, Haidong; Zong, Xi; Li, Rui; Wan, Guangpeng; Wang, Dongdong; Yang, Su; Yu, Wenyuan; Zhang, Ying; Hu, Haiyan. Preparation method and intermediate of Larotrectinib. Assignee Suzhou Southeast Pharmaceuticals Co., Ltd., Peop. Rep. China. CN 107987082. (2018).
Cefiderocol CAS# 1225208-94-5 头孢德罗
Cefiderocol, also known as S-649266, is a potent siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain. S-649266 shows potent in vitro activity against the non-ferme...
Reference: Aoki, Toshiaki; Yoshizawa, Hidenori; Yamawaki, Kenji; Yokoo, Katsuki; Sato, Jun; Hisakawa, Shinya; Hasegawa, Yasushi; Kusano, Hiroki; Sano, Masayuki; Sugimoto, Hideki; Nishitani, Yasuhiro; Sato, Takafumi; Tsuji, Masakatsu; Nakamura, Rio; Nishikawa, Toru; Yamano, Yoshinori. Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship. European Journal of Medicinal Chemistry. Volume 155. Pages 847-868. Journal; Online Computer File. (2018).
Alosetron Hydrochloride CAS# 122852-69-1 盐酸阿洛司琼
Alosetron is a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensor...
Pan, Li; Ji, Lei; Zheng, Yulin; Huang, Shaolin; Cheng, Maosheng. Improved process for the synthesis of Alosetron hydrochloride. Zhongguo Yaowu Huaxue Zazhi. Volume 12. Issue 4. Pages 222-224. 2002.
Siponimod CAS# 1230487-00-9 辛波莫德
Siponimod, also known as BAF-312, is a a potent and orally selective S1P Receptor Modulator with EC50 value of 0.39nM for S1P1 receptors and 0.98nM for S1P5 receptors, respectively. Development of sph...
Reference: Pan, Shifeng; Gray, Nathanael S.; Gao, Wenqi; Mi, Yuan; Fan, Yi; Wang, Xing; Tuntland, Tove; Che, Jianwei; Lefebvre, Sophie; Chen, Yu; Chu, Alan; Hinterding, Klaus; Gardin, Anne; End, Peter; Heining, Peter; Bruns, Christian; Cooke, Nigel G.; Nuesslein-Hildesheim, Barbara. Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator. ACS Medicinal Chemistry Letters. Volume 4. Issue 3. Pages 333-337. Journal; Online Computer File. (2013).
Abemaciclib CAS# 1231929-97-7 阿贝西利
Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplast...
Reference：Chan ED. Combination of anti-human VEGFR2 antibody and abemaciclib for treatment of non-small cell lung cancer. WO 2015130540 (2015).
Clofarabine CAS# 123318-82-1 克罗拉滨
Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which inhibi...
Cen, Yana; Sauve, Anthony A. Efficient Syntheses of Clofarabine and Gemcitabine From 2-Deoxyribonolactone. Nucleosides, Nucleotides & Nucleic Acids. Department of Pharmacology. Weill Medical College of Cornell University. New York, USA. Volume 29. Issue 2. Pages 113-122. 2010
Tenapanor CAS# 1234423-95-0
Tenapanor, also known as AZD-1722 and RDX 5791, is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidn...
Reference: Richter, Jindrich; Dammer, Ondrej; Krejcik, Lukas; Hejtmankova, Ludmila; Lustig, Petr; Dousa, Michal. Preparation of tenapanor free base and its salts. Assignee Zentiva K.S., Czech Rep. WO 2019091503. (2019).
Netarsudil CAS# 1254032-66-0 奈他地尔游离碱
Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outfl...
Reference: Sturdivant, Jill M.; Delong, Mitchell A.; Chambournier, Gilles; Pamment, Michael G.; Fedij, Victor. Process for the preparation of kinase inhibitors and intermediates thereof. WO 2017086941. (Assignee Aerie Pharmaceuticals, Inc., USA)
Gilteritinib CAS# 1254053-43-4 吉瑞替尼
Gilteritinib, also known as ASP2215, is a potent FLT3/AXL inhibitor, which showed potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations. In invitro, among the 7...
Reference: Yue, Qinglei; Zhou, Zhiguo; Gao, Qiang; Zheng, Baofu. Preparation of Gilteritinib derivatives as inhibitors of FLT3-Axl. Assignee Shanghai Haoyuan Medchemexpress Co., Ltd., Peop. Rep. China. CN 106083821. (2016).
Alectinib CAS# 1256580-46-7 艾乐替尼
Alectinib, also known as AF802, or CH5424802 or RO5424802, is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against c...
Reference: Xu, Xuenong. Alectinib preparation method. CN 104402862. (Assignee Suzhou Miracpharma Technology Co., Ltd., Peop. Rep. China)
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