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Cefditoren Pivoxil CAS# 117467-28-4 头孢妥仑匹酯
Cefditoren Pivoxil is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Cefditoren pivoxil is a prodrug that is rapidly ...
Sakagami, Kenji; Atsumi, Kunio; Yamamoto, Yuichi; Tamura, Atsuhi; Yoshida, Takashi; Nishihata, Ken; Fukatsu, Shunzo. Synthesis and oral activity of pivaloyloxymethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate (ME1207) and its related compound. Chemical & Pharmaceutical Bulletin. Pharm. Res. Cent. Meiji Seika Kaisha, Ltd. Yokohama, Japan 222. Volume 39. Issue 9. Pages 2433-6. 1991
Nebivolol CAS# 118457-14-0 奈比洛尔
Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and, in Europe, also for left ventricular failure. It is highly cardioselective...
Sheth, Rakesh; Attanti, Srinivasarao Veeravenkata; Patel, Hasmukh Mathurbhai; Gupta, Vinodkumar; Nadkarni, Sunil Sadanand. Process for preparation of Nebivolol from 6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol and 6-fluoro-3,4-dihydro-2-oxiranyl-2H-benzopyran. Assignee Torrent Pharmaceuticals Limited, India. WO 2006025070. (2006).
Omidenepag Isopropyl CAS# 1187451-19-9
Omidenepag isopropyl is a novel, selective, non-prostanoid EP2 receptor agonist. It can be used for treatment of open-angle glaucoma and ocular hypertension. Omidenepag isopropyl is a prodrug that is ...
This synthetic route was from WO2009113600.
Baricitinib CAS# 1187594-09-7 巴瑞克替尼
Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM). INCB028050 inhibits intracell...
Reference: Xu, Jiaojiao; Cai, Jin; Chen, Junding; Zong, Xi; Wu, Xuan; Ji, Min; Wang, Peng. An efficient synthesis of baricitinib. Journal of Chemical Research. Volume 40. Issue 4. Pages 205-208. Journal. (2016).
Levacetylleucine CAS# 1188-21-2 N-乙酰-L-亮氨酸
Levacetylleucine (N-acetyl-L-leucine, NALL) has demonstrated both cellular and animal bioactivity consistent with neuroprotective and lysosome-modulating effects. In vitro, NALL induces nuclear transl...
Preprogramming Complex Hydrogel Responses using Enzymatic Reaction NetworksBy: Postma, Sjoerd G. J.; et alAngewandte Chemie, International Edition (2017), 56(7), 1794-1798
Carglumic acid CAS# 1188-38-1 N-氨基甲酰-L-谷氨酸
Carglumic acid is an orphan drug, marketed by Orphan Europe under the trade name Carbaglu. Carglumic acid is used for the treatment of hyperammonaemia in patients with N-acetylglutamate synthase defic...
Verardo, Giancarlo; Geatti, Paola; Strazzolini, Paolo Synthetic Communications Volume 37 Issue 11 Pages 1833-1844 Journal 2007
Sofosbuvir CAS# 1190307-88-0 索非布韦
Sofosbuvir, also known as PSI-7977 and GS7977 (brand names Sovaldi and Virunon), is a drug used for hepatitis C virus (HCV) infection, with a high cure rate. It inhibits the RNA polymerase that the he...
Reference: Wilhelm, Thorsten; Schoene, Olga. Synthesis of sofosbuvir nucleoside phosphoramidate via hydride reduction of ketone. WO 2018134343. (Sandoz AG, Switz)
Vibegron CAS# 1190389-15-1 维贝格龙
Vibegron, also known as MK-4618, is a potent and selective Beta 3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder (OAB). Vibegron has no unacceptable toxicity in preclinical speci...
Highly diastereoselective total synthesis of Vibegron, a drug for overactive bladder diseaseBy: Adarsh, D. R.; et alTetrahedron Letters (2025), 155, 155429
Acanthoic Acid CAS# 119290-87-8 1-苯苄羧酸,7-乙烯基-1,2,3,4,4a,6,7,8,8a,9,10,10a-十二氢-1,4a,7-三甲基-,(1R,4aR,7S,8aS,10aS)-
Acanthoic acid is a pimaradiene diterpene isolated from Acanthopanax koreanum. It has been reported to have anti-inflammatory activities. Acanthoic acid downregulates LPS-induced TNF-α, IL-6 and IL-1β...
Enantioselective Synthesis of the Antiinflammatory Agent (-)-Acanthoic AcidBy: Ling, Taotao; et alJournal of Organic Chemistry (2001), 66(26), 8843-8853
Fruquintinib CAS# 1194506-26-7 呋喹替尼
Fruquintinib, also known as HMPL-013, is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activ...
Patent#: CN112724110
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