Cefditoren Pivoxil CAS# 117467-28-4 头孢妥仑匹酯
Cefditoren Pivoxil is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Cefditoren pivoxil is a prodrug that is rapidly hydrolyzed by intestinal esterases during absorption to the microbiologically active cefditoren, an active aminothiazolyl cephalosporin. Cefditoren inactivates penicillin binding proteins (PBPs) thereby interfering with peptidoglycan synthesis and inhibiting bacterial cell wall synthesis.
📌 参考资料/链接：
Sakagami, Kenji; Atsumi, Kunio; Yamamoto, Yuichi; Tamura, Atsuhi; Yoshida, Takashi; Nishihata, Ken; Fukatsu, Shunzo. Synthesis and oral activity of pivaloyloxymethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate (ME1207) and its related compound. Chemical & Pharmaceutical Bulletin. Pharm. Res. Cent. Meiji Seika Kaisha, Ltd. Yokohama, Japan 222. Volume 39. Issue 9. Pages 2433-6. 1991
Sakagami, Kenji; Atsumi, Kunio; Yamamoto, Yuichi; Tamura, Atsuhi; Yoshida, Takashi; Nishihata, Ken; Fukatsu, Shunzo. Synthesis and oral activity of pivaloyloxymethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate (ME1207) and its related compound. Chemical & Pharmaceutical Bulletin. Pharm. Res. Cent. Meiji Seika Kaisha, Ltd. Yokohama, Japan 222. Volume 39. Issue 9. Pages 2433-6. 1991
📄 详细内容
CAS No. 117467-28-4 头孢妥仑匹酯Cefditoren Pivoxil synthetic routes
Sakagami, Kenji; Atsumi, Kunio; Yamamoto, Yuichi; Tamura, Atsuhi; Yoshida, Takashi; Nishihata, Ken; Fukatsu, Shunzo. Synthesis and oral activity of pivaloyloxymethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate (ME1207) and its related compound. Chemical & Pharmaceutical Bulletin. Pharm. Res. Cent. Meiji Seika Kaisha, Ltd. Yokohama, Japan 222. Volume 39. Issue 9. Pages 2433-6. 1991
产品链接: CAS No. 117467-28-4 ››
Sakagami, Kenji; Atsumi, Kunio; Yamamoto, Yuichi; Tamura, Atsuhi; Yoshida, Takashi; Nishihata, Ken; Fukatsu, Shunzo. Synthesis and oral activity of pivaloyloxymethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate (ME1207) and its related compound. Chemical & Pharmaceutical Bulletin. Pharm. Res. Cent. Meiji Seika Kaisha, Ltd. Yokohama, Japan 222. Volume 39. Issue 9. Pages 2433-6. 1991
产品链接: CAS No. 117467-28-4 ››