Acanthoic Acid CAS# 119290-87-8 1-苯苄羧酸,7-乙烯基-1,2,3,4,4a,6,7,8,8a,9,10,10a-十二氢-1,4a,7-三甲基-,(1R,4aR,7S,8aS,10aS)-

Acanthoic acid is a pimaradiene diterpene isolated from Acanthopanax koreanum. It has been reported to have anti-inflammatory activities. Acanthoic acid downregulates LPS-induced TNF-α, IL-6 and IL-1β production in BALF, attenuates lung histopathologic changes, and inhibits inflammatory cytokines by stopping TNF-α, IL-6 and IL-1β production and NF-κB activation in LPS-stimulated alveolar macrophages.