网站主页>>>数据中心>>>工艺路线数据>>>Zavegepant CAS# 1337918-83-8 4-(1,2-二氢-2-氧-3-喹啉)-N-((1R)-1-((7-甲基-1H-吭唑-5-基)甲基)-2-(4-(1-甲基-4-哌啶啶)-1-哌嗪酰)-2-氧乙基)-1-哌啶羧酰胺
Zavegepant CAS# 1337918-83-8 4-(1,2-二氢-2-氧-3-喹啉)-N-((1R)-1-((7-甲基-1H-吭唑-5-基)甲基)-2-(4-(1-甲基-4-哌啶啶)-1-哌嗪酰)-2-氧乙基)-1-哌啶羧酰胺
Zavegepant, also known as Vazegepant, BHV-3500 and BMS 742413, is a highly potent, selective and structurally unique small molecule CGRP receptor antagonist. Vazegepant is the first and only CGRP receptor antagonist for intranasal administration currently in development for the acute treatment of migraine.
📌 参考资料/链接：
Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal deliveryBy: Chaturvedula, Prasad V.; et alBioorganic & Medicinal Chemistry Letters (2013), 23(11), 3157-3161
Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal deliveryBy: Chaturvedula, Prasad V.; et alBioorganic & Medicinal Chemistry Letters (2013), 23(11), 3157-3161
📄 详细内容
CAS No. 1337918-83-8 4-(1,2-二氢-2-氧-3-喹啉)-N-((1R)-1-((7-甲基-1H-吭唑-5-基)甲基)-2-(4-(1-甲基-4-哌啶啶)-1-哌嗪酰)-2-氧乙基)-1-哌啶羧酰胺Zavegepant synthetic routes
Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal deliveryBy: Chaturvedula, Prasad V.; et alBioorganic & Medicinal Chemistry Letters (2013), 23(11), 3157-3161
产品链接: CAS No. 1337918-83-8 ››
Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal deliveryBy: Chaturvedula, Prasad V.; et alBioorganic & Medicinal Chemistry Letters (2013), 23(11), 3157-3161
产品链接: CAS No. 1337918-83-8 ››