CAS: 1337918-83-8; (R)-N-(3-(7-Methyl-1H-Indazol-5-yl)-1-(4-(1-Methylpiperidin-4-yl)Piperazin-1-yl)-1-Oxopropan-2-yl)-4-(2-Oxo-1,2-Dihydroquinolin-3-yl)Piperidine-1-Carboxamide

专利信息

专利号:WO-2025125353-A1
优先权日:2023-12-13
标题:Method of preparation of zavegepant, synthesis intermediates of zavegepant and methods of preparation thereof
发明人：SÃ?NCHEZ CASALS CARLES; FAZIO ZALÃ?NYI ZENO; BALLETTE ROBERTO
权利人:MOEHS IBERICA SL
摘要:The present invention relates to a method of preparation of zavegepant and to reaction intermediates useful in the preparation of zavegepant, to a method of preparation of said intermediates, and to the use of said intermediates in the preparation of zavegepant.

专利号:WO-2025209508-A1
优先权日:2024-04-03
标题:Method for preparing zavegepant intermediate and derivative thereof
发明人：FAN HAISHENG; SUN QIAN; XU LIU; XU CHENGUANG; ZHAN YIPENG; HU YONGSHENG; LI JINJIN; GUO XIAOWEN; TAO ANPING; HUANG LUNING; GU HONG
权利人:SHANGHAI SYNCORES TECH INC; ZHEJIANG HUAHAI PHARM CO LTD
摘要:The present invention relates to the field of drug synthesis, and specifically relates to a method for preparing a Zavegepant intermediate and a derivative thereof. Specifically, the method comprises reacting a compound of formula II with a compound of formula III to obtain a compound of formula I, reacting the compound of formula I with isoamyl nitrite to obtain compound V, and removing a protecting group from the compound of formula V to obtain a compound of formula VI or a salt thereof. On the basis of the preparation method provided by the present invention, the raw materials are readily available, the production cost is relatively low, there are fewer synthesis steps, and the operation is simpler and more convenient.

专利号:CN-119306709-A
优先权日:2023-07-13
标题:Synthesis method of compound containing oxo-pyrido alicyclic heterocycle or alicyclic structure and novel intermediate

专利号:CN-119661422-A
优先权日:2024-11-06
标 题 :Synthesis method of 1- (1-methylpiperidine-4-yl) piperazine tri-hydrochloride