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Leniolisib CAS# 1354690-24-6 (S)-1-(3-((6-(6-甲氧基-5-(三氟甲基)吡啶-3-基)-5,6,7,8-四氢吡啶并[4,3-D]嘧啶-4-基)氨基)吡咯烷-1-基)丙-1-酮
Leniolisib, also known CDZ173, is a potent and selective phosphoinositide 3-kinase inhibitor (PI3Kδ inhibitor), which means it blocks a form of the protein called phosphoinositide 3-kinase delta (PI3...
Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective InhibitorsBy: Hoegenauer, Klemens; et alACS Medicinal Chemistry Letters (2017), 8(9), 975-980
Vaborbactam CAS# 1360457-46-0 法硼巴坦
Vaborbactam, also known as RPX7009, is a potent and selective beta-lactamase inhibitor. Vaborbactam shows broad-spectrum inhibitor, notably restoring the activity of carbapenems against KPC-producing ...
Reference: Hecker, Scott J.; Reddy, K. Raja; Totrov, Maxim; Hirst, Gavin C.; Lomovskaya, Olga; Griffith, David C.; King, Paula; Tsivkovski, Ruslan; Sun, Dongxu; Sabet, Mojgan; Tarazi, Ziad; Clifton, Matthew C.; Atkins, Kateri; Raymond, Amy; Potts, Kristy T.; Abendroth, Jan; Boyer, Serge H.; Loutit, Jeffrey S.; Morgan, Elizabeth E.; Durso, Stephanie; Dudley, Michael N. Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. Journal of Medicinal Chemistry. Volume 58. Issue 9. Pages 3682-3692. Journal. (2015)
Gozetotide CAS# 1366302-52-4
PSMA-11 (HBED-CC) is a small-molecule ligand designed for targeting prostate-specific membrane antigen (PSMA) and serves as a chelator for radiolabeling with ^68Ga. In preclinical binding studies, PSM...
Synthesis of HBED-CC-tris(tert-butyl ester) using a solid phase and a microwave reactorBy: Jerzyk, K.; et alTetrahedron (2021), 84, 132018
Lemborexant CAS# 1369764-02-2 莱博雷生
Lemborexant (INN) (code name E-2006, brand name Dayvigo) is a dual antagonist of the orexin OX1 and OX2 receptors which is under development by Eisai for the treatment of insomnia. Lemborexant was app...
Yoshida, Yu; Naoe, Yoshimitsu; Terauchi, Taro; Ozaki, Fumihiro; Doko, Takashi; Takemura, Ayumi; Tanaka, Toshiaki; Sorimachi, Keiichi; Beuckmann, Carsten T.; Suzuki, Michiyuki; Ueno, Takashi; Ozaki, Shunsuke; Yonaga, Masahiro. Discovery of (1R,2S)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist. Journal of Medicinal Chemistry. Volume 58. Issue 11. Pages 4648-4664. Journal. (2015).
Lotilaner CAS# 1369852-71-0
Lotilaner is an isoxazoline ectoparasiticide that acts as a potent inhibitor of γ-aminobutyric acid (GABA)-gated chloride channels and glutamate-gated chloride channels in arthropods. In vitro studies...
Process for the preparation of (S)-3-methyl-N-(2-oxo-2-((2, 2,2-trifluoroethyl) amino)ethyl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) thiophene-2-carboxamideBy: AnonymousIP.com Journal (2024), 24(6B), 1-6
Elbasvir CAS# 1370468-36-2 依巴司韦
Elbasvir, also known as MK-8742, is a HCV NS5A inhibitor, which is currently in phase 2b clinical trials as part of an all-oral, interferon-free regimen for the treatment of HCV infection. The NS5A pr...
Coburn, Craig A.; Meinke, Peter T.; Chang, Wei; Fandozzi, Christine M.; Graham, Donald J.; Hu, Bin; Huang, Qian; Kargman, Stacia; Kozlowski, Joseph; Liu, Rong; McCauley, John A.; Nomeir, Amin A.; Soll, Richard M.; Vacca, Joseph P.; Wang, Dahai; Wu, Hao; Zhong, Bin; Olsen, David B.; Ludmerer, Steven W. Discovery of MK-8742: An HCV NS5A inhibitor with broad genotype activity. ChemMedChem. Volume 8. Issue 12. Pages 1930-1940. Journal. (2013).
Ensartinib CAS# 1370651-20-9 恩沙替尼
Ensartinib, also known as X-396, is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral admi...
Patent#: WO2012048259
Ubrogepant CAS# 1374248-77-7 乌布吉泮
Ubrogepant, also known as MK-1602, is a potent and selective oral calcitonin gene-related peptide (CGRP) receptor antagonist. Ubrogepant, sold under the trade name Ubrelvy, is a medication used for th...
Belyk, Kevin M.; Cleator, Edward; Kuo, Shen-Chun; Maligres, Peter Emmanuel; Xiang, Bangping; Yasuda, Nobuyoshi; Yin, Jianguo. Process for preparing pyrrolo[2,3-b]pyridine derivatives as CGRP receptor antagonists. Assignee Merck Sharp & Dohme Corp., USA. 2013. WO 2013138418.
Atogepant CAS# 1374248-81-3
Atogepant, an oral calcitonin gene–related peptide (CGRP) receptor antagonist, demonstrated potent preclinical bioactivity with high selectivity for the human CGRP receptor. In vitro, it inhibited CGR...
Patent: WO2024150250
Trilaciclib CAS# 1374743-00-6
Trilaciclib (G1T28) is a potent, selective, reversible cyclin-dependent kinase 4/6 (CDK4/6) inhibitor developed for myelopreservation. In preclinical biochemical assays, it inhibited CDK4/cyclin D1 an...
Synthesis of N-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-aminesAssignee: G1 Therapeutics, Inc.Inventors: Smith, Alexander; et alWorld Intellectual Property OrganizationPatent#WO2018005865
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