1. 智能化融合:发展数据挖掘、集成、分析、可视化及人工智能工具,实现数据与文献、模型、计算等资源的有机融合,促进领域数智驱动科研新范式变革.
2. 标准化体系建设:以统一的数据标准管理体系为基础,系统整合全链条多源异构数据,聚焦高价值业务需求,精准构建结构合理、标注规范、语义清晰的数据资源.
3. 开放共享生态:开展数据提供方、使用方和服务方生态体系建设,实现多元主体间数据共享、共用、共治。.
4. 多模态数据处理:构建“全模态数据治理平台+高质量数据服务”一体化解决方案,提升非结构化数据处理能力.

Doravirine, also known as MK-1439, is a non-nucleoside reverse transcriptase inhibitor under development by Merck & Co. for use in the treatment of HIV/AIDS. MK-1439 is a novel NNRTI with a 50% inhibi...
Reference: Gauthier, Donald R., Jr.; Sherry, Benjamin D.; Cao, Yang; Journet, Michel; Humphrey, Guy; Itoh, Tetsuji; Mangion, Ian; Tschaen, David M. Highly Efficient Synthesis of HIV NNRTI Doravirine. Organic Letters. Volume 17. Issue 6. Pages 1353-1356. Journal; Online Computer File. (2015).
Safinamide, also known as FCE-26743 and EMD-1195686, is a drug indicated for the treatment of Parkinson's disease with multiple methods of action. Potential additional uses might be restless legs synd...
Park, Ki Duk; Yang, Xiao-Fang; Dustrude, Erik T.; Wang, Yuying; Ripsch, Matthew S.; White, Fletcher A.; Khanna, Rajesh; Kohn, Harold. Chimeric agents derived from the functionalized amino acid, lacosamide, and the α-aminoamide, safinamide: evaluation of their inhibitory actions on voltage-gated sodium channels, and antiseizure and antinociception activities and comparison with lacosamide and safinamide. Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy. (ACS Chemical Neuroscience Volume 6 Issue 2)
Oteseconazole (VT-1161) is a potent, selective oral antifungal agent that inhibits fungal CYP51 (lanosterol 14α-demethylase), disrupting ergosterol synthesis. In preclinical assays, it showed strong a...
Oteseconazole: First Approved Orally Bioavailable and Selective CYP51 Inhibitor for the Treatment of Patients with Recurrent Vulvovaginal CandidiasisBy: De, Surya K.Current Medicinal Chemistry (2023), 30(37), 4170-4175
Erdafitinib, also known as JNJ-42756493, is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral adminis...
Saxty, Gordon; Murray, Christopher William; Berdini, Valerio; Besong, Gilbert Ebai; Hamlett, Christopher Charles Frederick; Johnson, Christopher Norbert; Woodhead, Steven John; Reader, Michael; Rees, David Charles; Mevellec, Laurence Anne; Angibaud, Patrick Rene; Freyne, Eddy Jean Edgard; Govaerts, Tom Cornelis Hortense; Weerts, Johan Erwin Edmond; Perera, Timothy Pietro Suren; Gilissen, Ronaldus Arnodus Hendrika Joseph; Wroblowski, Berthold; Lacrampe, Jean Fernand Armand; Papanikos, Alexandra; Querolle, Oliver Alexis Georges; Pasquier, Elisabeth Therese Jeanne; Pilatte, Isabelle Noeelle Constance; Bonnet, Pascal Ghislain Andre; Embrechts, Werner Constant Johan; Akkari, Rhalid; Meerpoel, Lieven Assignee Astex Therapeutics Limited,Nov 3, 2011 WO 2011135376 A1 UK 2011
Avacopan, also known as CCX168, is an orally active, selective and potent C5aR inhibitor. CCX168 blocked the C5a binding, C5a-mediated migration, calcium mobilization, and CD11b upregulation in U937 c...
Arylboration of Enecarbamates for the Synthesis of Borylated Saturated N-HeterocyclesBy: Trammel, Grace L.; et alAngewandte Chemie, International Edition (2022), 61(46), e202212117
Etelcalcetide is a calcium-sensing receptor agonist for the treatment of secondary hyperparathyroidism for patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is administered int...
Reference: Cui, Sheng; Ranganathan, Krishnakumar; Crockett, Richard; Chen, Ying; Swietlow, Aleksander; Crossley, Kevin; Shi, Yun; Decroos, Karel; Moniotte, Etienne. Solution phase method for preparing etelcalcetide. WO 2016154580. (Assignee Amgen Inc., USA)
Grazoprevir, also known as MK5172, is a drug approved for the treatment of hepatitis C. Grazoprevir is a second generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets. I...
Reference: Kuethe J, Zhong YL, Yasuda N, Beutner G, Linn K, Kim M, Marcune B, Dreher SD, Humphrey G, Pei T. Development of a practical, asymmetric synthesis of the hepatitis C virus protease inhibitor MK-5172. Org Lett. 2013 Aug 16;15(16):4174-7. doi: 10.1021/ol401864t. Epub 2013 Aug 6. PubMed PMID: 23919347.
Vericiguat is a soluble guanylate cyclase (sGC) stimulator that enhances cyclic GMP production in cardiovascular tissues. In vitro, it directly stimulates sGC in the presence or absence of nitric oxid...
Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart FailureBy: Follmann, Markus; et alJournal of Medicinal Chemistry (2017), 60(12), 5146-5161
Gadoxetate Disodium is a liver-specific magnetic resonance imaging (MRI) contrast agent. Gadoxetate Disodium is preferentially taken up by normal functioning hepatocytes, so normal hepatic tissue is e...
Novel process for the preparation of gadolinium complex of (4s)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9- triazaundecanedioic acid disodium (gadoxetate disodium); Pullagurla, Manik Reddy; Pitta, Bhaskar Reddy; Namani, Suresh Babu; Rangisetty, Jagadeesh Babu; Assignee Biophore India Pharmaceuticals Pvt. Ltd., India; 2017; Patent Information; Dec 07, 2017; WO 2017208258 A1
Pibrentasvir, also known as ABT-530, is a protease inhibitor potentially for the treatment of HCV infection.
Reference: Wagner R, Randolph JT, Patel SV, Nelson L, Matulenko MA, Keddy R, Pratt JK, Liu D, Krueger AC, Donner PL, Hutchinson DK, Flentge C, Betebenner D, Rockway T, Maring CJ, Ng TI, Krishnan P, Pilot-Matias T, Collins C, Panchal N, Reisch T, Dekhtyar T, Mondal R, Stolarik DF, Gao Y, Gao W, Beno DA, Kati WM. Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530). J Med Chem. 2018 May 10;61(9):4052-4066. doi: 10.1021/acs.jmedchem.8b00082. Epub 2018 Apr 23. PubMed PMID: 29653491.
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