Grazoprevir CAS# 1350514-68-9 格拉瑞韦
Grazoprevir, also known as MK5172, is a drug approved for the treatment of hepatitis C. Grazoprevir is a second generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets. It has good activity against a range of HCV genotype variants, including some that are resistant to most currently used antiviral medications.
📌 参考资料/链接：
Reference: Kuethe J, Zhong YL, Yasuda N, Beutner G, Linn K, Kim M, Marcune B, Dreher SD, Humphrey G, Pei T. Development of a practical, asymmetric synthesis of the hepatitis C virus protease inhibitor MK-5172. Org Lett. 2013 Aug 16;15(16):4174-7. doi: 10.1021/ol401864t. Epub 2013 Aug 6. PubMed PMID: 23919347.
Reference: Kuethe J, Zhong YL, Yasuda N, Beutner G, Linn K, Kim M, Marcune B, Dreher SD, Humphrey G, Pei T. Development of a practical, asymmetric synthesis of the hepatitis C virus protease inhibitor MK-5172. Org Lett. 2013 Aug 16;15(16):4174-7. doi: 10.1021/ol401864t. Epub 2013 Aug 6. PubMed PMID: 23919347.
📄 详细内容
CAS No. 1350514-68-9 格拉瑞韦Grazoprevir synthetic routes
Kuethe J, Zhong YL, Yasuda N, Beutner G, Linn K, Kim M, Marcune B, Dreher SD, Humphrey G, Pei T. Development of a practical, asymmetric synthesis of the hepatitis C virus protease inhibitor MK-5172. Org Lett. 2013 Aug 16;15(16):4174-7. doi: 10.1021/ol401864t. Epub 2013 Aug 6. PubMed PMID: 23919347.
产品链接: CAS No. 1350514-68-9 ››
Kuethe J, Zhong YL, Yasuda N, Beutner G, Linn K, Kim M, Marcune B, Dreher SD, Humphrey G, Pei T. Development of a practical, asymmetric synthesis of the hepatitis C virus protease inhibitor MK-5172. Org Lett. 2013 Aug 16;15(16):4174-7. doi: 10.1021/ol401864t. Epub 2013 Aug 6. PubMed PMID: 23919347.
产品链接: CAS No. 1350514-68-9 ››