Etelcalcetide CAS# 1350514-68-9 格拉瑞韦
Etelcalcetide is a calcium-sensing receptor agonist for the treatment of secondary hyperparathyroidism for patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is administered intravenously at the end of each dialysis session. It functions by binding to and activating the calcium-sensing receptor (CaSR) in the parathyroid gland as an allosteric activator, resulting in PTH reduction and suppression. Elevated PTH is often observe in patients with CKD. AMG 416 is in clinic trials for the treatment of secondary hyperparathyroidism in hemodialysis patients.
📌 参考资料/链接：
Reference: Cui, Sheng; Ranganathan, Krishnakumar; Crockett, Richard; Chen, Ying; Swietlow, Aleksander; Crossley, Kevin; Shi, Yun; Decroos, Karel; Moniotte, Etienne. Solution phase method for preparing etelcalcetide. WO 2016154580. (Assignee Amgen Inc., USA)
Reference: Cui, Sheng; Ranganathan, Krishnakumar; Crockett, Richard; Chen, Ying; Swietlow, Aleksander; Crossley, Kevin; Shi, Yun; Decroos, Karel; Moniotte, Etienne. Solution phase method for preparing etelcalcetide. WO 2016154580. (Assignee Amgen Inc., USA)
📄 详细内容
CAS No. 1350514-68-9 格拉瑞韦Etelcalcetide synthetic routes
Cui, Sheng; Ranganathan, Krishnakumar; Crockett, Richard; Chen, Ying; Swietlow, Aleksander; Crossley, Kevin; Shi, Yun; Decroos, Karel; Moniotte, Etienne. Solution phase method for preparing etelcalcetide. WO 2016154580. (Assignee Amgen Inc., USA)
产品链接: CAS No. 1350514-68-9 ››
Cui, Sheng; Ranganathan, Krishnakumar; Crockett, Richard; Chen, Ying; Swietlow, Aleksander; Crossley, Kevin; Shi, Yun; Decroos, Karel; Moniotte, Etienne. Solution phase method for preparing etelcalcetide. WO 2016154580. (Assignee Amgen Inc., USA)
产品链接: CAS No. 1350514-68-9 ››