临床前CDMO研发筛选相关化合物

CDMO是Contract Development and Manufacturing Organization的缩写，即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药（特别是创新药）工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力，是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化：创新性合成路线设计、工艺参数优化. 2, 中试放大：实验室工艺向规模化生产的转化 3, 注册批生产：支持客户新药申报的验证批生产. 4, 商业化生产：药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测：2026年全球CDMO市场规模：预计达1,189亿美元 2033年全球CDMO市场规模：预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物，已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前，在多肽、ADC、CGT等新型药物赛道的驱动下，全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力，全球市占率有望持续提升，行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
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临床前CDMO研发化合物筛选

CAS: 57-83-0

Progesterone (NSC 9704)

中文名称:孕酮; 黄体素; 黄体酮
CAS号:57-83-0
分子式: C21H30O2 分子量: 314.46
产品形式: free base
研发状态: Not yet recruiting
研发用途: Poor Ovarian Response
研究机构: Shi Yun; Capital Medical University; Dongzhimen Hospital Beijing
研发日期: June 1 2024
研发阶段: Early Phase 1
Progesterone (NSC 9704, NSC 64377, Pregn-4-ene-3,20-dione) is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.

CAS: 57818-44-7

ABTL-0812

中文名称:α-羟基油酸
CAS号:57818-44-7
分子式: C18H32O3 分子量: 296.44
产品形式: free base
研发状态: Completed
研发用途: Cancer
研究机构: Ability Pharmaceuticals SL; Hospital Clinic of Barcelona; Institut Català d''Oncologia
研发日期: Feb-14
研发阶段: Phase 1
ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.

CAS: 57817-89-7

Stevioside

中文名称: 甜菊苷
CAS号:57817-89-7
分子式: C38H60O18 分子量: 804.87
产品形式: free base
研发状态: Not yet recruiting
研发用途: pH; Microbiome; Dental Plaque
研究机构: Hospital Infantil de Mexico Federico Gomez
研发日期: Oct-23
研发阶段: Phase 1 : Phase 2
Stevioside is a natural sweetener extracted from leaves of Stevia rebaudiana (Bertoni) Bertoni.

CAS: 57808-66-9

Domperidone

中文名称: 多潘立酮
CAS号:57808-66-9
分子式: C22H24ClN5O2 分子量: 425.91
产品形式: free base
研发状态: Completed
研发用途: Gastric Residual Volume
研究机构: Ain Shams University
研发日期: October 10 2022
研发阶段: Phase 3
Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.

CAS: 57-66-9

Probenecid

中文名称:丙磺舒
CAS号:57-66-9
分子式: C13H19NO4S 分子量: 285.36
产品形式: free base
研发状态: Recruiting
研发用途: Chronic Pain; Drug Dependence of Morphine Type; Symptom Withdrawal
研究机构: University of Calgary
研发日期: October 31 2023
研发阶段: Phase 2
Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. Probenecid is also a clinically used broad-spectrum Pannexin1 (Panx1) blocker.

CAS: 57-63-6

Ethinyl Estradiol

中文名称:炔雌醇
CAS号:57-63-6
分子式: C20H24O2 分子量: 296.40
产品形式: free base
研发状态: Recruiting
研发用途: Healthy Participants
研究机构: Incyte Corporation
研发日期: May 7 2024
研发阶段: Phase 1
Ethinyl Estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.