临床前CDMO研发筛选相关化合物

CDMO是Contract Development and Manufacturing Organization的缩写，即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药（特别是创新药）工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力，是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化：创新性合成路线设计、工艺参数优化. 2, 中试放大：实验室工艺向规模化生产的转化 3, 注册批生产：支持客户新药申报的验证批生产. 4, 商业化生产：药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测：2026年全球CDMO市场规模：预计达1,189亿美元 2033年全球CDMO市场规模：预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物，已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前，在多肽、ADC、CGT等新型药物赛道的驱动下，全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力，全球市占率有望持续提升，行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
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临床前CDMO研发化合物筛选

CAS: 571190-30-2

Palbociclib

中文名称:帕布昔利布
CAS号:571190-30-2
分子式: C24H29N7O2 分子量: 447.53
产品形式: Free Base
研发状态: Recruiting
研发用途: Advanced Clear Cell Renal Carcinoma (Ccrcc); Papillary Renal Cell Carcinoma (Prcc)
研究机构: National Cancer Institute (NCI); National Institutes of Health Clinical Center (CC)
研发日期: April 24 2024
研发阶段: Phase 1 : Phase 2
Palbociclib (Ibrance, PD 0332991) is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) and Cdk6 with IC50 of 11 nM and 16 nM, respectively.

CAS: 57-00-1

Creatine

中文名称:肌酸
CAS号:57-00-1
分子式: C4H9N3O2 分子量: 131.13
产品形式: free base
研发状态: Withdrawn
研发用途: Myocardium; Injury; Myocardial Infarction; Myocardial Ischemia
研究机构: Shifa Tameer-e-Millat University; Rawalpindi Institute of Cardiology
研发日期: Dec-25
研发阶段: Phase 2
Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue.Creatine can inhibits the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.

CAS: 56974-61-9

Gabexate Mesylate

中文名称:甲磺酸加贝酯
CAS号:56974-61-9
分子式: C16H23N3O4.CH4O3S 分子量: 417.48
产品形式: Mesylate
研发状态: Completed
研发用途: Healthy Volunteers
研究机构: Ono Pharmaceutical Co. Ltd
研发日期: July 1 2020
研发阶段: Phase 1
Gabexate Mesylate(FOY) is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.

CAS: 56-92-8

Histamine 2HCl

中文名称:组胺二盐酸盐
CAS号:56-92-8
分子式: C5H9N3.2HCl 分子量: 184.07
产品形式: Dihydrochloride
研发状态: Recruiting
研发用途: Pregnancy Complications
研究机构: Hospital Universitari Vall d''Hebron Research Institute; DR Healthcare
研发日期: February 16 2024
研发阶段: --
Histamine(Ceplene) is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.

CAS: 56-85-9

L-Glutamine

中文名称:L-谷氨酰胺
CAS号:56-85-9
分子式: C5H10N2O3 分子量: 146.14
产品形式: free base
研发状态: Recruiting
研发用途: Chronic Lymphocytic Leukemia
研究机构: University of Wisconsin Madison
研发日期: June 13 2022
研发阶段: --
L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells.

CAS: 56-69-9

5-hydroxytryptophan (5-HTP)

中文名称:5-羟色胺酸
CAS号:56-69-9
分子式: C11H12N2O3 分子量: 220.22
产品形式: free base
研发状态: Completed
研发用途: Crohn Disease; Ulcerative Colitis; Fatigue; Remission
研究机构: University Hospital Ghent
研发日期: December 6 2018
研发阶段: Phase 2
5-Hydroxytryptophan (5-HTP, NSC-92523), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor for the treatment of depression.