CAS: 56-85-9; (S)-2,5-Diamino-5-Oxopentanoic Acid

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6899-04-3 5959-95-5 102747-84-2

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CAS号71989-20-3 FM°C-L-谷氨酰胺 | CAS号56-86-0 L-谷氨酸 | CAS号60-24-2 巯基乙醇 | CAS号30924-93-7 N-(叔丁氧羰基)-L-谷氨酸... | CAS号2490-97-3 N-乙酰-L-谷氨酰胺 | CAS号56-85-9 L-谷氨酰胺 | CAS号1101-67-3 丹磺酰-L-谷氨酰胺 | CAS号50-35-1 沙利度胺 | CAS号149-87-1 DL-焦谷氨酸 | CAS号328-50-7 α-酮戊二酸 | CAS号18465-19-5 2-Keto-glutaram... | CAS号39537-23-0 L-丙氨酰-L-谷氨酸盐 | CAS号3081-61-6 L-茶氨酸 | CAS号56-86-0 L-谷氨酸 | CAS号945623-40-5 monosodium glutamate | CAS号3343-29-1 N-α-邻苯二酰-L-谷氨酰胺

Monosodium L-Glutamate置于imidazole Buffer Pseudomonas Taetrolens Y-30 Glutamine Synthetase Ec 6.3.1.2,Ammonium Chloride,Magnesium Chloride体系中,化学反应生成 L-谷氨酰胺
参考文献:Purification And Characterization Of Glutamine Synthetase Ofpseudomonas Taetrolensy-30: An Enzyme Usable For Production Of Theanine By Coupling With The Alcoholic Fermentation System Of Baker's Yeast
标题:Purification And Characterization Of Glutamine Synthetase Ofpseudomonas Taetrolensy-30: An Enzyme Usable For Production Of Theanine By Coupling With The Alcoholic Fermentation System Of Baker's Yeast
摘要:在含有面包酵母酒精发酵系统的混合物中,作为甲胺同化生物分离出来的假单胞菌y-30的浓缩细胞提取物从谷氨酸和乙胺中反应生成了γ-谷氨酰乙酰胺(茶氨酸),用于atp再生.在含有 1%甲胺,1%甘油,0.5%酵母提取物和 0.2%多肽作为碳源和氮源的培养基上生长的生物体的提取物中分离出了谷氨酰胺合成酶(gs),该酶可能负责形成茶氨酸.通过凝胶过滤估计其分子质量为 660 Kda,通过 Sds 聚丙烯酰胺凝胶电泳估计其分子质量为 55 Kda.该酶的活性需要 Mg2+ 或 Mn2+.在谷氨酰胺形成的标准反应条件下(ph 8.0,30 Mm Mg2+),Gs 对甲胺和乙胺的反应活性分别为对氨反应活性的 7% 和 1%.与烷基胺的反应活性随混合物中二价阳离子的最佳反应 Ph 值的变化而变化:与乙胺的 Mg2+ 依赖性反应的最佳反应 Ph 值为 11.0,而 Mn2+ 依赖性反应的最佳反应 Ph 值为 8.5.在与 1000 毫摩尔乙胺(ph 值为 8.5 时含 3 毫摩尔 Mn2+)的最佳反应条件的混合物中,反应活性比标准反应条件下与氨的反应活性提高了 7%.分离出的 Gs 在与酵母发酵系统的混合物中形成了茶氨酸.
DOI:10.1271/bbb.68.1888

专利信息

专利号:US-6350595-B1
优先权日:1997-10-28
标题:Synthesis of polynucleotides having random sequences
发明人：NEUNER PHILIPPE
权利人:ISTITUTO DI RICERCHE DI MOLECO
摘要:Subject of this invention is a process for the chemical synthesis of polynucleotides having totally or partially random sequences, based on the utilization, as synthesis monomer units for the random sequence part, or presynthesized mononucleotides and dinucleotides. Said synthesis is carried out on separate supports, so that on each of those supports is alternated at least one reaction cycle wherein a mixture of said dinucleotides is bound, with at least one reaction cycle wherein a mononucleotide is bound, and that in a preferred embodiment at the end of the n cycles required for a codon synthesis, the supports are mixed and then redivided into one or more reaction containers. The resulting polynucleotides are such that, for the random sequence part, each trinucleotide unit is fit to match only a limited number of codons, predefined for each unity in number and sequence, and the genetic code degeneracy effects can thus be eliminated. FIG. 1 shows the chemical structure of the dinucleotides utilized as monomer units for the synthesis of codons forming the final sequence.

专利号:WO-9312076-A1
优先权日:1991-12-13
标题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS ROY
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-10865390-B2
优先权日:2018-02-12
标 题 :Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols
发明人：NI YE; ZHOU JIEYU; XU GUOCHAO; WANG YUE
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.

专利号:US-5283293-A
优先权日:1990-12-14
标 题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS R
权利人:CORVAS INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-2010279334-A1
优先权日:2007-10-31
标题 :Cyclodipeptide synthases (cdss) and their use in the synthesis of linear dipeptides
发明人：SAUGUET LUDOVIC; THAI ROBERT; BELIN PASCAL; LECOQ ALAIN; GENET ROGER; PERNODET JEAN-LUC; GONDRY MURIEL
权利人:KYOWA HAKKO BIO CO LTD; CENTRE NAT RECH SCIENT; UNIV PARIS SUD 11; COMMISSARIAT ENERGIE ATOMIQUE
摘要:Use of CDSs in the synthesis of linear dipeptides, and applications thereof for the in vivo and in vitro synthesis of linear dipeptides, in particular Phe-Leu, Leu-Phe, Phe-Phe, Phe-Tyr, Tyr-Phe, Leu-Leu, Leu-Tyr, Tyr-Leu, Phe-Met, Met-Phe, Leu-Met, Met-Leu, Tyr-Met, Met-Tyr, Met-Met, Tyr-Tyr, Ile-Met, Met-Ile, Leu-Ile, Ile-Leu using the corresponding polynucleotides.

专利号:US-2005101763-A1
优先权日:2003-09-30
标 题 :Synthesis of photolabile 2-(2-nitrophenyl)propyloxycarbonyl protected amino acids
发明人：DELISI CHARLES P; LAURSEN RICHARD A; BHUSHAN KUMAR R
权利人:UNIV BOSTON
摘要:The 2-(2-nitrophenyl)propyloxycarbonyl (NPPOC) group has been introduced as a photolabile amino protecting group for amino acids to be used as building blocks in photolithographic solid-phase peptide synthesis. NPPOC-protected amino acids were found to be cleaved in the presence of UV light about twice as fast as the corresponding o-nitroveratryloxycarbonyl (NVOC)-protected amino acids. The protected amino acids are of particular use in the synthesis of peptide arrays.