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临床前CDMO研发化合物筛选
Idebenone
中文名称:艾地苯醌
CAS号:58186-27-9
分子式: C19H30O5 分子量: 338.44
产品形式: free base
研发状态: Completed
研发用途: Friedreich''s Ataxia
研究机构: Santhera Pharmaceuticals
研发日期: Apr-11
研发阶段: Phase 3
Idebenone (CV-2619) is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.
Pyrimethamine
中文名称:乙胺嘧啶
CAS号:58-14-0
分子式: C12H13ClN4 分子量: 248.71
产品形式: free base
研发状态: Recruiting
研发用途: Head and Neck Cancer; Cancer of the Head and Neck
研究机构: Washington University School of Medicine; Tilde Sciences
研发日期: August 3 2023
研发阶段: Early Phase 1
Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug.
Miltefosine
中文名称: 米替福新
CAS号:58066-85-6
分子式: C21H46NO4P 分子量: 407.57
产品形式: free base
研发状态: Not yet recruiting
研发用途: Cutaneous Leishmaniases; Treatment Adherence; Primary Health Care; Drug Evaluation
研究机构: Centre Hospitalier de Cayenne
研发日期: August 8 2022
研发阶段: --
Miltefosine (Hexadecylphosphocholine) inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral drug for Visceral leishmaniasis, effective against both promastigotes and amastigotes.
Clavulanic acid
中文名称:克拉维酸
CAS号:58001-44-8
分子式: C8H9NO5 分子量: 199.16
产品形式: free base
研发状态: Recruiting
研发用途: Pediatric; Bacterial Infections
研究机构: Kaizen Bioscience Co.
研发日期: August 9 2023
研发阶段: Phase 1
Clavulanic acid is a naturally occurring, powerful bacterial β-lactamase inhibitor. The beta-lactam ring found in clavulanic acid binds to the active site of beta-lactamase, resulting in enzyme inactivation and enhancing the antibacterial activity of beta-lactam antibiotics like amoxicillin.
Centhaquin
中文名称:2-(2-(4-(3-甲基苯基)-1-哌嗪基)乙基)喹啉
CAS号:57961-90-7
分子式: C22H25N3 分子量: 331.45
产品形式: free base
研发状态: Completed
研发用途: Hypovolemic Shock; Blood Loss
研究机构: Pharmazz Inc.
研发日期: May 29 2017
研发阶段: Phase 2
Centhaquin (Centhaquine, PMZ-2010), a potential agent for treatment of haemorrhagic shock, can augment cardiac output, reduce systemic vascular resistance in haemorrhagic models.
Clozapine
中文名称:氯氮平
CAS号:5786-21-0
分子式: C18H19ClN4 分子量: 326.82
产品形式: free base
研发状态: Recruiting
研发用途: Treatment Resistant Schizophrenia
研究机构: All India Institute of Medical Sciences Bhubaneswar
研发日期: August 31 2023
研发阶段: Phase 4
Clozapine (HF 1854, LX 100-129) is an atypical antipsychotic drug by acting as a 5-HT antagonist, used in the treatment of schizophrenia.
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