CAS: 58001-44-8; (2R,5R,Z)-3-(2-Hydroxyethylidene)-7-Oxo-4-Oxa-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid

该化合物是一种乳液化合物,它是一种乳液酶酶的强大抑制剂,由某些细菌生产,以产生抗氨酸抗氨素;它来自对氯氟化碳的发酵,其特征是,氯氟烃酸能够形成一种稳定的复合物,与乳液形成稳定的复合体,从而保护共同管理的抗生素(如氨基西林)不受降解.这一特征增强了抗抗菌菌菌株的功效.该化合物通常与其他抗生素结合使用,以扩大其活动范围.氯氟烃酸是白色的对非白晶体粉,在水中溶解,并具有包括碳,氢,氮和氧在内的分子配方.它在临床环境中的使用主要是作为治疗抗生酶细菌引起的感染的混合疗法的一部分,因此它是抗生菌抗生素抗药性斗争中的一个基本组成部分.

结构式图片

上下游产品

CAS号57943-84-7 Benzyl Clavulanate | CAS号57943-82-5 methyl clavulanate | CAS号57943-81-4 sodium [2R-(2al... | CAS号69779-62-0 9-deoxyclavulan... | CAS号83670-73-9 methyl 4-(2-hyd... | CAS号58243-07-5 methyl 3-(dieth... | CAS号83670-77-3 methyl-4-aza-8-... | CAS号83670-76-2 6,7-DIHYDROPYRA...

合成工艺路线路线简述

    📜Benzyl Clavulanate置于palladium On Activated Charcoal 氢气体系中,用 乙醇 作为反应溶剂,化学反应 0.75H,以84%的收率获得产物克拉维酸
    参考文献:Brown,Allan G.; Corbett,David F.; Goodacre,Jennifer,Journal Of The Chemical Society. Perkin Transactions I,1984,# 4,P. 635-650
    标题:Brown,Allan G.; Corbett,David F.; Goodacre,Jennifer,Journal Of The Chemical Society. Perkin Transactions I,1984,# 4,P. 635-650

    海关参考信息

    专利信息


    专利号:US-2024197774-A1
    优先权日:2021-04-16
    标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
    发明人:LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
    权利人:UNIV TEXAS
    摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

    专利号:US-10793495-B2
    优先权日:2015-08-14
    标 题:Synthesis of polyaryl substituted aryl compounds
    发明人:BOULOS RAMIZ; FEUTRILL JOHN
    权利人:BOULOS & COOPER PHARMACEUTICALS PTY LTD
    摘要:A method for the synthesis of a aryl compound of Formula (1).n nU T-W—R 1 ) n    (1)

    专利号:EP-0303364-A1
    优先权日:1987-08-10
    标 题:Cloning and nucleotide sequence determination of the isopenicillin N synthetase gene from streptomyces clavuligerus
    发明人:JENSEN SUSAN E; WESTLAKE DONALD W S; LESKIW BRENDA K; AHARONOWITZ YAIR DEP OF MIBROB; MEVARECH MOSHEIR DEP OF MIBROB
    权利人:UNIV ALBERTA
    摘要:The gene coding for the enzyme Isopenicillin N Synthetase (IPNS) isolated from the prokaryote Streptomyces clavuligerus is cloned and sequenced. The corresponding amino acid sequence is also determined. The enzyme IPNS controls the rate of synthesis of the β-­lactam family of antibiotics. The nucleotide sequence is incorporated into a vector to effect a transformation of a suitable host microorganism. Such a transformed microorganism is useful in making in vitro synthesis of the β-lactams more practical and in whole cell fermentations to produce higher levels of β-lactams.

    专利号:US-11059835-B2
    优先权日:2014-08-15
    标 题 :Synthesis of cephalosporin compounds
    发明人:WALLER DAVID; GAZDA GREGORY; MINDEN ZACHARY; BARTON LISA; LEIGH CLIFTON
    权利人:MERCK SHARP & DOHME
    摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction.

    专利号:US-2023286915-A1
    优先权日:2020-10-07
    标 题 :Synthesis of pyrrole acid derivatives
    发明人:WILKINSON ANDREW; COOPER LAN; ORR DAVID; FINLAYSON JONATHAN; BUNT ADAM; KIRKHAM JAMES; LYTH DAVID; BLADES KEVIN
    权利人:INFEX THERAPEUTICS LTD
    摘要:This invention relates to the synthesis of compounds that can be used to treat bacterial infections in combination with other antibacterial agents, and more specifically in combination with a class of antibacterial agents known as carbapenems. The compounds resulting from the novel methods of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.

    专利号:US-11744867-B2
    优先权日:2017-02-14
    标 题 :Modulation of microbial synthesis of 4-ethylphenol and 4-ethylphenyl sulfate in behavior and disease
    发明人:NEEDHAM BRITTANY D; MAZMANIAN SARKIS K; SHARON GIL; FUNABASHI MASANORI; FISCHBACH MICHAEL A; HSIAO ELAINE Y; PATTERSON PAUL H
    权利人:CALIFORNIA INST OF TECHN; UNIV CALIFORNIA
    摘要:Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset, or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1186/cc8877
    摘要:Augustin P, Kermarrec N, Muller-Serieys C, Lasocki S, Chosidow D, Marmuse JP, Valin N, Desmonts JM, Montravers P. Risk factors for multidrug resistant bacteria and optimization of empirical antibiotic therapy in postoperative peritonitis. Crit Care. 2010;14(1):R20.
    参考文献:10.2165/11319010-000000000-00000
    摘要:Johansson S, Wallander MA, de Abajo FJ, García Rodríguez LA. Prospective drug safety monitoring using the UK primary-care General Practice Research Database: theoretical framework, feasibility analysis and extrapolation to future scenarios. Drug Saf. 2010 Mar 01;33(3):223–32. doi: 10.2165/11319010-000000000-00000.
    参考文献:10.1016/j.jaci.2009.11.032
    摘要:Torres MJ, Ariza A, Mayorga C, Doña I, Blanca-Lopez N, Rondon C, Blanca M. Clavulanic acid can be the component in amoxicillin-clavulanic acid responsible for immediate hypersensitivity reactions. Journal of Allergy and Clinical Immunology. 2010 Feb;125(2):502–505.e2. doi: 10.1016/j.jaci.2009.11.032.
    参考文献:10.1007/s10195-011-0144-0
    摘要:Alecci V, Valente M, Crucil M, Minerva M, Pellegrino C, Sabbadini DD. Comparison of primary total hip replacements performed with a direct anterior approach versus the standard lateral approach: perioperative findings. Journal of Orthopaedics and Traumatology. 2011 Jul 12;12(3):123–9. doi: 10.1007/s10195-011-0144-0.
    参考文献:10.1007/s10096-011-1168-3
    摘要:Egea P, López-Cerero L, Navarro MD, Rodríguez-Baño J, Pascual A. Assessment of the presence of extended-spectrum beta-lactamase-producing Escherichia coli in eggshells and ready-to-eat products. European Journal of Clinical Microbiology & Infectious Diseases. 2011 Jul 14;30(9):1045. doi: 10.1007/s10096-011-1168-3.
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