CAS: 57808-66-9; 5-Chloro-1-[1-[3-(2,3-Dihydro-2-Oxo-1H-Benzimidazol-1-yl)Propyl]-4-Piperidinyl]-1,3-Dihydro-2H-Benzimidazol-2-One

上下游产品

chloroform 4-methyl-2-pentanone 1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one 5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

1‐(3‐aminopropyl)‐1,3‐dihydro‐2H‐benzo[d]Imidazol‐2‐one,5-氯-1,3-二氢-1-(4-哌啶基)-2H-苯并咪唑-2-酮置于sodium Bromide,Sodium Sulfite体系中,用 硝基甲烷 作为反应溶剂,化学反应 32.0H,以51%的收率获得产物多潘立酮
参考文献:一种胃动力药物多潘立酮的合成方法
标题:一种胃动力药物多潘立酮的合成方法
摘要:一种胃动力药物多潘立酮的合成方法,包括如下步骤:在反应容器中加入5-氯-1-(4-哌啶基)-苯并咪唑-2-酮(3)0.12Mol,硝基甲烷1100-1300Ml,亚硫酸钠0.31-0.33Mol,1-(3-胺丙基)苯并咪唑-2-酮0.13-0.15Mol,溴化钠3-5G,控制搅拌速度110-130Rpm,回流30-32H,将反应液倒入氯化钠溶液中,降低溶液温度至3oc-5°C,析出固体,将固体用盐溶液洗涤,甲苯溶液洗涤,脱水剂脱水,在丙睛中重结晶,得白色固体多潘立酮;其中,步骤所述的氯化钠溶液的质量分数为15-20%,步骤所述的盐溶液为硫酸钾,硝酸钠中的任意一种.

专利信息

专利号:WO-9614060-A1
优先权日:1994-11-04
标题 :Use of receptor agonists to stimulate superoxide dismutase activity
发明人：MARKLUND STEFAN L; STRAALIN PONTUS
权利人:MARKLUND STEFAN L; STRAALIN PONTUS
摘要:The present invention relates to the use of a substance for the manufacture of a composition for stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells. In particular, the invention relates to the use of a substance for the manufacture of a composition for prophylaxis or treatment of a disease or disorder connected with the presence or formation of superoxide radicals and other toxic intermediates derived from the superoxide radical. Further, the invention relates to a method for determining the effect of a substance with respect to stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells and to substances which have been selected by said method. Within the scope of the invention is a method of preventing, diminishing, controlling or inhibiting a disease or disorder connected with the presence or formation of superoxide radicals and other toxic intermediates derived from the superoxide radical in a patient who has been established to have a high risk of developing a such disease or disorder, or who has developed a such disease or disorder, the method comprising administering an effective amount of a substance which is capable of stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells.

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:WO-0054773-A1
优先权日:1999-03-12
标题:Dopamine agonists in combination with nitric oxide donors, compositions and methods of use
发明人：GARVEY DAVID S
权利人:NITROMED INC; GARVEY DAVID S
摘要:The present invention is directed to novel compositions comprising at least one dopamine agonist in combination with at least one nitric oxide donor (i.e. compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are substrates for nitric oxide synthase). The novel compositions may optionally comprise at least one therapeutic agent, such as, a vasoactive agent, an antimetic agent, and mixtures thereof. The dopamine agonist is preferably apomorphine. The present invention is also directed to methods for treating and/or preventing sexual dysfunctions and/or enhancing sexual responses in patients. In other embodiments, the present invention is directed to methods treating or preventing neurodegenerative diseases, mitochondrial diseases, spinal cord injury, central or psychostimulant addiction, senile dementia, circulatory disorders, cardiovascular disorders, hyperprolactinaemia or myopia. The compounds and/or compositions of the present invention can also be provided in the form of a pharmaceutical kit.

专利号:US-12291505-B2
优先权日:2016-07-04
标题 :Methods for the synthesis of deuterated dextromethorphan
发明人：JOHNSON MATT; ZHAO CUNXIANG; MENG WEIHUA; LU ZHIJUN; LI YAN
权利人:AVANIR PHARMACEUTICALS INC
摘要:The application describes methods for making a deuterated dextromethorphan of Formula (I), deuterated dextromethorphan produced by these methods, and pharmaceutically acceptable salts thereof.

专利号:US-2025228841-A1
优先权日:2024-01-12
标题 :Compositions affecting pigment production and methods for treatment of bacterial diseases
发明人：Lee Wai Yip Thomas; LO KAI YIP GEORGE
权利人:APTORUM THERAPEUTICS LTD
摘要:Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II):The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, the bacterial infections are staphylococcal infections. Compositions are provided that include compounds of formula II in combination with one or more antibiotics or one or more staphyloxanthin-synthesis-inhibiting compounds.

专利号:US-2008227851-A1
优先权日:2007-03-12
标题 :Laulimalide and laulimalide analogs
发明人：WENDER PAUL A
权利人:WENDER PAUL A
摘要:Novel laulimalide analogs, methods for the treatment of proliferative disease and processes for the synthesis of laulimalide and novel laulimalide analogs are described.