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临床前CDMO研发化合物筛选
Quizartinib (AC220)
中文名称:奎扎替尼
CAS号:950769-58-1
分子式: C29H32N6O4S 分子量: 560.67
产品形式: free base
研发状态: Completed
研发用途: Hepatic Impairment; Moderate Impaired Hepatic Function
研究机构: Daiichi Sankyo
研发日期: September 22 2020
研发阶段: Phase 1
Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3.
Gemcitabine (LY-188011)
中文名称:吉西他滨
CAS号:95058-81-4
分子式: C9H11F2N3O4 分子量: 263.20
产品形式: Free Base
研发状态: Recruiting
研发用途: Biliary Tract Cancer; Gemox Chemotherapy
研究机构: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University; Suzhou Suncadia Biopharmaceuticals Co. Ltd.
研发日期: April 1 2024
研发阶段: Phase 2
Gemcitabine (LY-188011, NSC 613327), a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.
Lotamilast (RVT-501)
CAS号:947620-48-6
分子式: C26H24N4O5 分子量: 472.49
产品形式: free base
研发状态: Unknown status
研发用途: Atopic Dermatitis
研究机构: Dermavant Sciences GmbH; Dermavant Sciences Inc.
研发日期: February 5 2018
研发阶段: Phase 1
Lotamilast (RVT-501, E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8 nM.
Salmeterol Xinafoate
中文名称:昔美酸沙美特罗
CAS号:94749-08-3
分子式: C36H45NO7 分子量: 603.75
产品形式: xinafoate
研发状态: Completed
研发用途: Respiratory Disorders
研究机构: GlaxoSmithKline
研发日期: Oct-07
研发阶段: --
Salmeterol Xinafoate(GR 33343X xinafoate,Salmetedur) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.
Piperine
中文名称:胡椒碱
CAS号:94-62-2
分子式: C17H19NO3 分子量: 285.34
产品形式: free base
研发状态: Completed
研发用途: Plasma Levels of Different Curcuminoids Preparations
研究机构: University of Jordan; Nutritional Fundamentals for Health
研发日期: September 20 2022
研发阶段: Not Applicable
Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.
Avutometinib
中文名称:RO5126766(CH5126766)抑制剂
CAS号:946128-88-7
分子式: C21H18FN5O5S 分子量: 471.46
产品形式: free base
研发状态: Recruiting
研发用途: Refractory Cancer; CNS Tumors; CNS Tumor Adult; CNS Tumor Childhood; MAP Kinase Family Gene Mutation; NF1; Plexiform Neurofibroma; Low-grade Glioma; Optic Pathway Gliomas; Neuroblastoma; Primary Brain Tumor; Solid Tumor; Solid Tumor Adult; Solid Carcinoma; Central Nervous System Tumor
研究机构: Memorial Sloan Kettering Cancer Center
研发日期: October 20 2023
研发阶段: Phase 1
Avutometinib(RO5126766,CH5126766,VS 6766, CKI-27, R-7304, RG-7304) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM,19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.
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