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临床前CDMO研发化合物筛选
Famotidine
中文名称: 法莫替丁
CAS号:76824-35-6
分子式: C8H15N7O2S3 分子量: 337.45
产品形式: free base
研发状态: Active not recruiting
研发用途: Healthy Volunteers
研究机构: PMV Pharmaceuticals Inc
研发日期: September 19 2023
研发阶段: Phase 1
Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.
Natamycin
中文名称:纳他霉素
CAS号:7681-93-8
分子式: C33H47NO13 分子量: 665.73
产品形式: free base
研发状态: Completed
研发用途: Corneal Ulcer; Eye Infections Fungal
研究机构: University of California San Francisco; Aravind Eye Hospitals India; Dartmouth-Hitchcock Medical Center; Lumbini Eye Institute and Hospital; Bharatpur Eye Hospital; National Eye Institute (NEI)
研发日期: May-10
研发阶段: Phase 3
Natamycin (Pimaricin), a natural and versatile anti-fungal agent during fermentation by the bacterium Streptomyces natalensis, commonly found in soil; with little to no flavour interference
Potassium Iodide
中文名称:碘化钾
CAS号:7681-11-0
分子式: K+I- 分子量: 166.00
产品形式: Inorganic salt
研发状态: Withdrawn
研发用途: Dietary Intervention; Pregnancy Jail; Iodine Deficiency
研究机构: Fundacio d''Investigacio en Atencio Primaria Jordi Gol i Gurina
研发日期: Nov-08
研发阶段: Not Applicable
Potassium Iodide is used to treat overactive thyroid and to protect the thyroid gland from the effects of radiation from inhaled or swallowed radioactive iodine.
Divalproex Sodium
中文名称: 双丙戊酸钠
CAS号:76584-70-8
分子式: C8H16O2.C8H15O2.Na 分子量: 310.41
产品形式: Sodium Salt
研发状态: Completed
研发用途: Schizophrenia; Bipolar Disorder; Psychotic Disorders
研究机构: Johnson & Johnson Pharmaceutical Research & Development L.L.C.
研发日期: Feb-09
研发阶段: Phase 1
Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.
Olaparib (AZD2281)
中文名称: 奥拉帕尼
CAS号:763113-22-0
分子式: C24H23FN4O3 分子量: 434.46
产品形式: free base
研发状态: Not yet recruiting
研发用途: Breast Cancer Triple Negative
研究机构: AHS Cancer Control Alberta
研发日期: July 1 2024
研发阶段: Phase 2
Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.
Triamcinolone Acetonide
中文名称: 曲安奈德
CAS号:76-25-5
分子式: C24H31FO6 分子量: 434.50
产品形式: free base
研发状态: Completed
研发用途: Vestibular Schwannoma
研究机构: Medical University of Vienna
研发日期: February 1 2020
研发阶段: Phase 1
Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.
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