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临床前CDMO研发化合物筛选
Paroxetine HCl
中文名称:盐酸帕罗西汀
CAS号:78246-49-8
分子式: C19H20FNO3.HCl 分子量: 365.83
产品形式: Hydrochloride
研发状态: Not yet recruiting
研发用途: Opioid Induced Respiratory Depression; Depressive Disorder; Anxiety Disorders
研究机构: Leiden University Medical Center
研发日期: March 15 2023
研发阶段: Phase 1
Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.
Diclofenac Diethylamine
中文名称:双氯芬酸二乙胺盐
CAS号:78213-16-8
分子式: C14H11Cl2NO2.C4H11N 分子量: 369.29
产品形式: Diethylamine
研发状态: Not yet recruiting
研发用途: Interaction
研究机构: Washington State University
研发日期: January 1 2024
研发阶段: Early Phase 1
Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.
Sepantronium Bromide
中文名称:4,9-二氢-1-(2-甲氧基乙基)-2-甲基-4,9-二氧代-3-(2-吡嗪甲基)-1H-萘并[2,3-D]咪唑溴化物
CAS号:781661-94-7
分子式: C20H19BrN4O3 分子量: 443.29
产品形式: Bromide
研发状态: Recruiting
研发用途: High-grade B-cell Lymphoma; Burkitt Lymphoma; Lymphoma B-Cell; Lymphoma Large B-Cell Diffuse; Lymphatic Diseases; Lymphoma High-Grade; C-MYC/BCL2 Double-Hit High-Grade B-Cell Lymphoma; C-MYC/BCL6 Double-Hit High-Grade B-Cell Lymphoma; C-Myc Gene Rearrangement
研究机构: Cothera Bioscience Inc
研发日期: December 9 2022
研发阶段: Phase 2
Sepantronium Bromide(YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.
Aztreonam
中文名称:氨曲南
CAS号:78110-38-0
分子式: C13H17N5O8S2 分子量: 435.43
产品形式: free base
研发状态: Completed
研发用途: Healthy
研究机构: Pfizer
研发日期: August 20 2021
研发阶段: Phase 1
Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection.
Dinaciclib (SCH727965)
中文名称:(2S)-1-[3-乙基-7-[[(1-氧代-3-吡啶基)甲基]氨基]吡唑并[1,5-A]嘧啶-5-基]-2-哌啶乙醇
CAS号:779353-01-4
分子式: C21H28N6O2 分子量: 396.49
产品形式: free base
研发状态: Terminated
研发用途: Cancer - Acute Myeloid Leukemia
研究机构: AbbVie; Merck Sharp & Dohme LLC
研发日期: July 23 2018
研发阶段: Phase 1
Dinaciclib (SCH727965, PS-095760) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM in cell-free assays, respectively. It also blocks thymidine (dThd) DNA incorporation. Dinaciclib induces apoptosis through the activation of caspases 8 and 9. Phase 3.
Citric acid
中文名称: 柠檬酸
CAS号:77-92-9
分子式: C6H8O7 分子量: 192.12
产品形式: Free Base
研发状态: Completed
研发用途: Noise Exposure; Sleep Disturbance; Sleep Hygiene; Metabolic Disturbance; Cognitive Change
研究机构: Göteborg University; University of Pennsylvania; University of Manitoba
研发日期: April 24 2022
研发阶段: Not Applicable
Citric acid is a weak organic acid that occurs naturally in citrus fruits. It is an intermediate in the citric acid cycle.
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