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临床前CDMO研发化合物筛选
Camphor
中文名称:(±)-樟脑(合成)
CAS号:76-22-2
分子式: C10H16O 分子量: 152.23
产品形式: free base
研发状态: Recruiting
研发用途: Idiopathic Pulmonary Arterial Hypertension
研究机构: Amsterdam UMC location VUmc
研发日期: March 1 2023
研发阶段: Phase 2
Camphor (2-Bornanone, Bornan-2-one, 2-Camphanone, Formosa) is a bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora and used topically as a skin antipruritic and as an anti-infective agent.
Ipragliflozin (ASP1941)
中文名称:伊格列净
CAS号:761423-87-4
分子式: C21H21FOS 分子量: 404.45
产品形式: free base
研发状态: Completed
研发用途: Type 2 Diabetes Mellitus
研究机构: Astellas Pharma Europe B.V.; Astellas Pharma Inc
研发日期: May 11 2016
研发阶段: Phase 3
Ipragliflozin (ASP1941) is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 value of 7.4 nM for hSGLT2 and a 254-fold selectivity versus SGLT1.
Solithromycin
中文名称:索利霉素
CAS号:760981-83-7
分子式: C43H65FN6O10 分子量: 845.01
产品形式: free base
研发状态: Terminated
研发用途: Pulmonary Disease Chronic Obstructive
研究机构: Imperial College London; Melinta Therapeutics Inc.
研发日期: Jul-15
研发阶段: Phase 2
Solithromycin (CEM-101, OP-1068), belonging to the well-known class of macrolide antibiotics that also includes azithromycin, is a potent bacterial protein synthesis inhibitor.
Enalapril Maleate
中文名称:马来酸依那普利
CAS号:76095-16-4
分子式: C20H28N2O5.C4H4O4 分子量: 492.52
产品形式: Maleate
研发状态: Completed
研发用途: Heart Failure With Reduced Ejection Fraction; Renal Insufficiency
研究机构: Cairo University
研发日期: February 1 2021
研发阶段: Not Applicable
Enalapril (MK-421) Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.
β-Cyclodextrin
中文名称:β-环糊精
CAS号:7585-39-9
分子式: C42H70O35 分子量: 1134.98
产品形式: Free Base
研发状态: Completed
研发用途: COVID-19
研究机构: Gilead Sciences
研发日期: July 21 2020
研发阶段: Phase 2 : Phase 3
β-Cyclodextrin (β-CD, Beta-Cyclodextrin) is a cyclic derivative of starch prepared from partially hydrolyzed starch (maltodextrin) by an enzymatic process. β-Cyclodextrin can be used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability.
Tanespimycin (17-AAG)
中文名称:坦螺旋霉素
CAS号:75747-14-7
分子式: C31H43N3O8 分子量: 585.69
产品形式: free base
研发状态: Terminated
研发用途: Adult Acute Basophilic Leukemia; Adult Acute Eosinophilic Leukemia; Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia
研究机构: National Cancer Institute (NCI)
研发日期: Apr-05
研发阶段: Phase 1
Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy. Phase 3.
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