专利号:US-5981240-A 优先权日:1996-11-27 标题:Enzyme-catalyzed synthesis of macromolecules in organic solvents 发明人:AKKARA JOSEPH A; BRUNO FERDINANDO F 权利人:US ARMY 摘要:A method is described for a simple, fast and efficient synthesis of homopolymers and copolymers by the enzymatic ring opening polymerization of lactones and lactides. The enzyme used is an ion paired protease. The advantage of this enzymatic system is in using small amount of enzyme per monomer and lower reaction time. Homopolymers and copolymers are synthesized with molecular weights between 1000 and 4600 daltons, and dispersity as low as 1.1. The monomer conversion after 4 days, for reactions catalyzed by protease S, has reached 100%. Different initiators are used to control the rate and degree of polymerization. Synthesis of block copolymers with defined block size and crystallinity are described in this invention. These biodegradable and bioerodable polyesters and copolyesters with controlled molecular weight, dispersity and crystallinity have applications in medical, drug, cosmetic and food industries.
专利号:US-6069250-A 优先权日:1995-12-14 标 题 :Method and compositions for the synthesis of dioxolane nucleosides with β-configuration 发明人:MANSOUR TAREK; CIMPOIA ALEX; BEDNARSKI KRZYSZTOF 权利人:IAF BIOCHEM INT 摘要:The present invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. In particular, this invention relates to the stereoselective synthesis of the beta (cis) isomer by glycosylating the base with an intermediate of formula (II) below a temperature of about -10 DEG C. wherein R1 and L are as defined herein.
专利号:US-7435861-B2 优先权日:2005-04-29 标 题 :Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates 发明人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID 权利人:CARDAX PHARMACEUTICALS INC 摘要:A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.
专利号:US-2025250302-A1 优先权日:2024-02-05 标题:Synthesis of self-assembling artificial proteins utilizing a host-guest system and uses thereof 发明人:SANDANARAJ BRITTO S; KHYADE ASHWINI RAJENDRA; HATI KSHITISH CHANDRA 权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES PUNE IISER PUNE 摘要:The invention relates to an efficient method for synthesizing self-assembling artificial proteins (SAPs) utilizing a catalytic host-guest system. The process involves encapsulating hydrophobic probes with cyclodextrin, performing site-specific protein bioconjugation, and employing a second catalysis cycle for enhanced labeling. SAPs produced through this method are versatile and find applications in therapeutic delivery and diagnostics. The process is simplified, scalable, cost-effective, and environmentally sustainable, addressing the challenges of traditional SAP synthesis. By offering improved yield, functionality, and structural integrity, this invention advances the potential of SAPs in medical and industrial fields.
专利号:US-10981850-B2 优先权日:2019-04-15 标 题 :One-step flow-mediated synthesis of cannabidiol (CBD) and derivatives 发明人:PORCO JOHN A; BEELER AARON B; BROWN LAUREN E; TRILLES RICHARD V 权利人:UNIV BOSTON 摘要:Herein are described apparatus and processes for the preparation of cannabinoids, such as cannabidiol (CBD) and derivatives thereof. The apparatus and processes described can be used for the one-step, flow-mediated synthesis of cannabidiol and derivatives with improved overall yield, material throughput, and product purity relative to batch processes.
专利号:WO-2024057083-A1 优先权日:2022-11-28 标 题 :Process for the synthesis of selectively alkylated cyclodextrins 发明人:IVÃ?NYI RÓBERT; TUZA KATA; SZENTE LAJOS; PUSKÃ?S ISTVÃ?N; SZÅ?CS LEVENTE; KURKAYEV ABDULA 权利人:CYCLOLAB CYCLODEXTRIN R&D LABORATORY LTD 摘要:The present invention generally relates to a process for the synthesis of selectively alkylated cyclodextrins. More particularly, the present invention relates to a process of cyclodextrin alkylation in a selective manner yielding hexakis(2,6-di-O-alkyl)-alpha-cyclodextrin, heptakis(2,6-di-O-alkyl)-beta-cyclodextrin and octakis(2,6-di-O-alkyl)-gamma-cyclodextrin.
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合成参考文献
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