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临床前CDMO研发化合物筛选
Levosimendan
中文名称:左西孟旦
CAS号:141505-33-1
分子式: C14H12N6O 分子量: 280.28
产品形式: free base
研发状态: Not yet recruiting
研发用途: Heart Failure New York Heart Association Class III; Heart Failure New York Heart Association Class IV; Heart Failure Systolic; Heart Failure With Reduced Ejection Fraction
研究机构: Medical University of Bialystok; Medical Research Agency Poland; University of Opole; Medical University of Lodz; Poznan University of Medical Sciences; Nicolaus Copernicus University; National Institute of Cardiology Warsaw Poland; John Paul II Hospital Krakow; Azienda Ospedaliera dei Colli
研发日期: January 1 2021
研发阶段: Phase 4
Levosimendan(OR1259,OR1855,Simsndan) is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.
Atuveciclib (BAY-1143572)
中文名称:阿维西利
CAS号:1414943-88-6
分子式: C18H18FN5O2S 分子量: 387.43
产品形式: Free Base
研发状态: Completed
研发用途: Leukemia
研究机构: Bayer
研发日期: February 19 2015
研发阶段: Phase 1
Atuveciclib (BAY-1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with IC50 values of 13 nM for CDK9/CycT and the ratio of IC50 values for CDK2/CDK9 is about 100. Outside the CDK family, It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3α and GSK3β respectively.
ABT-751 (E7010)
中文名称:N-[2-[(4-羟基苯基)氨基]-3-吡啶基]-4-甲氧基苯磺酰胺
CAS号:141430-65-1
分子式: C18H17N3O4S 分子量: 371.41
产品形式: free base
研发状态: Completed
研发用途: Disseminated Neuroblastoma; Recurrent Neuroblastoma
研究机构: Children''s Oncology Group; National Cancer Institute (NCI)
研发日期: Jan-07
研发阶段: Phase 2
ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.
PX-12
中文名称: 2-(仲丁基二硫基)-1H-咪唑
CAS号:141400-58-0
分子式: C7H12N2S2 分子量: 188.31
产品形式: free base
研发状态: Completed
研发用途: Metastatic Cancer; Advanced Cancer
研究机构: Cascadian Therapeutics Inc.; Seagen Inc.
研发日期: Jun-08
研发阶段: Phase 1
PX-12 (DB05448, 1-methyl propyl 2-imidazolyl disulfide) is a potent thioredoxin-1 (Trx-1) inhibitor by irreversibly thioalkylation of Cys73 of Trx-1. Phase 2.
Pentamidine isethionate
中文名称: 羟乙磺酸喷他脒
CAS号:140-64-7
分子式: C19H24N4O2.2C2H6O4S 分子量: 592.68
产品形式: isethionate
研发状态: Completed
研发用途: Pneumocystis Jirovecii Infection
研究机构: Central Hospital Nancy France
研发日期: April 1 2020
研发阶段: --
Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.
Gentamicin Sulfate
中文名称:硫酸庆大霉素
CAS号:1405-41-0
分子式: H2SO4.xUnspecified 分子量: N/A
产品形式: Sulfate
研发状态: Not yet recruiting
研发用途: Acute Mesenteric Ischemia
研究机构: Assistance Publique - Hôpitaux de Paris
研发日期: September 1 2024
研发阶段: Phase 3
Gentamycin Sulfate (NSC-82261, SCH9724) is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms.
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