CAS: 1414943-88-6; 4-(4-Fluoro-2-Methoxyphenyl)-N-(3-((S-Methylsulfonimidoyl)Methyl)Phenyl)-1,3,5-Triazin-2-Amine
该化合物是针对依赖环球的动脉(CDKs)的一个小分子抑制剂,专门为肿瘤学和细胞循环调节研究的研究应用而开发.作为一种种族混合物,它为调查CCDK抑制的立体化学影响提供了平衡的剖面,提供了结构活动关系的洞察力.它的主要优点包括:对CDK2和CDK9的高度抵抗力,使其成为研究癌症模型中转录规程和流行病的宝贵工具.种族成形形式允许与对应性衍生物进行比较研究,促进加深对动脉选择性和作用的手力影响的理解.它适合于体外和临床前的研究,它支持CDK依赖路径的机械探索.
- 英文名称4-(4-Fluoro-2-Methoxyphenyl)-N-(3-((S-Methylsulfonimidoyl)Methyl)Phenyl)-1,3,5-Triazin-2-Amine
- 中文名称阿维西利
- IUPAC名称(3-((4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl)amino)benzyl)(imino)(methyl)-l6-sulfanone
- 其它别名Atuveciclib Racemate; (Rac)-4-(4-Fluoro-2-Methoxyphenyl)-N-{3-[(S-Methylsulfonimidoyl)Methyl]Phenyl}-1,3,5-Triazin-2-Amine; 4-(4-Fluoro-2-Methoxyphenyl)-N-(3-((S-Methylsulfonimidoyl)Methyl)Phenyl)-1,3,5-Triazin-2-Amine
- CAS编号1414943-88-6
- MFCD编号:MFCD30502894
- 分子式:C18H18FN5O2S分子量:387.44
- 产品CID: 633176
- 同类组份化合物CAS1414943-88-6 (racemic)1414943-94-4
- 产品分类Inhibitors/Agonists → Cell Cycle → CDK
物理性质
合成工艺路线路线简述
海关参考信息
- 2902300000-甲苯
2905110000-甲醇
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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主要参考文献
1: Ruff JP, Kretz AL, Kornmann M, Henne-Bruns D, Lemke J, Traub B. The Novel, Orally Bioavailable CDK9 Inhibitor Atuveciclib Sensitises Pancreatic Cancer Cells to TRAIL-induced Cell Death. Anticancer Res. 2021 Dec;41(12):5973-5985. doi: 10.21873/anticanres.15416. 12(21):1776-1793. doi: 10.1002/cmdc.201700447. Epub 2017 Oct 16.
3: Ni W, Zhang F, Zheng L, Wang L, Liang Y, Ding Y, Yik JHN, Haudenschild DR, Fan S, Hu Z. Cyclin-Dependent Kinase 9 (CDK9) Inhibitor Atuveciclib Suppresses Intervertebral Disk Degeneration via the Inhibition of the NF-κB Signaling Pathway. Front Cell Dev Biol. 2020 Sep 10;8:579658. doi: 10.3389/fcell.2020.579658.
4: Brisard D, Eckerdt F, Marsh LA, Blyth GT, Jain S, Cristofanilli M, Horiuchi D, Platanias LC. Antineoplastic effects of selective CDK9 inhibition with atuveciclib on cancer stem-like cells in triple-negative breast cancer. Oncotarget. 2018 Dec 18;9(99):37305-37318. doi: 10.18632/oncotarget.26468.
合成参考文献
参考文献:10.1055/s-0041-1737909
摘要:Dohi T, Zhdankin VV, Kumar R, Rimi R, Soni S, Uttam B, China H. Recyclable Hypervalent Iodine Reagents in Modern Organic Synthesis. Synthesis. 2022 Mar 23;54(12):2731–48. doi: 10.1055/s-0041-1737909.
参考文献:10.1124/mol.119.115964
摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
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