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临床前CDMO研发化合物筛选
IDO-IN-2
中文名称:alpha-环己基-5H-咪唑并[5,1-a]异吲哚-5-乙醇
CAS号:1402836-58-1
分子式: C18H22N2O 分子量: 282.38
产品形式: free base
研发状态: Completed
研发用途: Solid Tumor
研究机构: Genentech Inc.
研发日期: July 28 2015
研发阶段: Phase 1
IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue) is a a potent IDO1 inhibitor with IC50 of 38 nM.
SC-43
CAS号:1400989-25-4
分子式: C21H13ClF3N3O2 分子量: 431.80
产品形式: free base
研发状态: Unknown status
研发用途: Advanced Non-small-cell Lung Cancer; Advanced Biliary Tract Cancer
研究机构: RaND Biosciences
研发日期: May 1 2021
研发阶段: Phase 1 : Phase 2
SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity.
TVB-2640
CAS号:1399177-37-7
分子式: C27H29N5O 分子量: 439.55
产品形式: Free Base
研发状态: Recruiting
研发用途: Prostatic Neoplasms Castration-Resistant
研究机构: Weill Medical College of Cornell University; Sagimet Biosciences Inc.
研发日期: November 20 2023
研发阶段: Phase 1
TVB-2640 (ASC-40, FASN-IN-2) is an orally bioavailable, pharmacological fatty acid synthase (FAS/FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis.
Proxalutamide (GT0918)
中文名称:普克鲁胺
CAS号:1398046-21-3
分子式: C24H19F4N5O2S 分子量: 517.50
产品形式: Free base
研发状态: Completed
研发用途: Efficacy and Safety
研究机构: Suzhou Kintor Pharmaceutical Inc
研发日期: March 5 2021
研发阶段: Phase 3
Proxalutamide (GT0918) is a second-generation androgen receptor antagonist that binds to the ligand-binding domain of AR with an IC50 of 32 nM in the AR competive binding assays.
Amphotericin B
中文名称:两性霉素B
CAS号:1397-89-3
分子式: C47H73NO17 分子量: 924.08
产品形式: free base
研发状态: Recruiting
研发用途: Primary Visceral Leishmaniasis
研究机构: Drugs for Neglected Diseases; Novartis Pharmaceuticals
研发日期: December 27 2022
研发阶段: Phase 2
Amphotericin B (AMB, NSC 527017) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.
Lodenafil
中文名称:5-(2-乙氧基-5-((4-(2-羟乙基)哌嗪-1-基)磺基)苯基)-1-甲基-3-丙基-1,6-二氢-7H-吡唑啉[4,3-d]嘧啶-7-酮
CAS号:139755-85-4
分子式: C23H32N6O5S 分子量: 504.60
产品形式: free base
研发状态: Completed
研发用途: Erectile Dysfunction
研究机构: Cristália Produtos Químicos Farmacêuticos Ltda.
研发日期: Jan-09
研发阶段: Phase 4
Lodenafil (Hydroxyhomosildenafil) is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED).
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