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临床前CDMO研发化合物筛选
BAY 1217389
CAS号:1554458-53-5
分子式: C27H24F5N5O3 分子量: 561.50
产品形式: free base
研发状态: Completed
研发用途: Medical Oncology
研究机构: Bayer
研发日期: February 27 2015
研发阶段: Phase 1
BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.
Istradefylline
中文名称: 伊曲茶碱
CAS号:155270-99-8
分子式: C20H24N4O4 分子量: 384.43
产品形式: free base
研发状态: Active not recruiting
研发用途: Parkinson Disease; Tremor
研究机构: Georgetown University; Kyowa Kirin Inc.
研发日期: January 20 2023
研发阶段: Phase 4
Istradefylline (KW-6002) is a selective adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM. Phase 3.
Ritonavir (ABT-538)
中文名称:利托那韦
CAS号:155213-67-5
分子式: C37H48N6O5S2 分子量: 720.94
产品形式: free base
研发状态: Not yet recruiting
研发用途: Biological Availability; Healthy Participants
研究机构: Pfizer
研发日期: February 14 2025
研发阶段: Phase 1
Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.
Bimatoprost
中文名称:比马前列素
CAS号:155206-00-1
分子式: C25H37NO4 分子量: 415.57
产品形式: free base
研发状态: Completed
研发用途: Healthy Volunteers
研究机构: Laboratoires Thea
研发日期: February 27 2023
研发阶段: Phase 1
Bimatoprost(AGN 192024) is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
Plerixafor (AMD3100) 8HCl
中文名称:盐酸普乐沙福
CAS号:155148-31-5
分子式: C28H54N8.8HCl 分子量: 794.47
产品形式: Octahydrochloride
研发状态: Not yet recruiting
研发用途: Stem Cell Transplant Complications
研究机构: AHS Cancer Control Alberta
研发日期: April 1 2024
研发阶段: Phase 2
Plerixafor (AMD3100, JM 3100,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.
Rosiglitazone (BRL-49653) maleate
中文名称:马来酸罗格列酮
CAS号:155141-29-0
分子式: C18H19N3O3S.C4H4O4 分子量: 473.50
产品形式: Maleate
研发状态: Terminated
研发用途: Non-small Cell Lung Cancer
研究机构: Sun Yat-sen University
研发日期: Mar-16
研发阶段: Phase 2
Rosiglitazone maleate (BRL-49653C), a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPAR-γ) with IC50 of 42 nM. Rosiglitazone maleate also modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.
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