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临床前CDMO研发化合物筛选
Emodepside
中文名称:艾默德斯
CAS号:155030-63-0
分子式: C60H90N6O14 分子量: 1119.39
产品形式: Free Base
研发状态: Not yet recruiting
研发用途: Strongyloides Stercoralis Infection; Strongyloidiasis
研究机构: Swiss Tropical & Public Health Institute; National Institute of Public Health Vientiane Laos
研发日期: May 1 2024
研发阶段: Phase 2
Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. Emodepside activates Ca-dependent SLO-1-like K channels.
Carmustine
中文名称:卡莫司汀
CAS号:154-93-8
分子式: C5H9Cl2N3O2 分子量: 214.05
产品形式: free base
研发状态: Unknown status
研发用途: Relapsed/Refractory Malignant Lymphomas
研究机构: State Budgetary Healthcare Institution National Medical Surgical Center N.A. N.I. Pirogov Ministry of Health of Russia
研发日期: January 22 2016
研发阶段: Phase 2
Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.
Efavirenz
中文名称: 依法韦仑
CAS号:154598-52-4
分子式: C14H9ClF3NO2 分子量: 315.67
产品形式: free base
研发状态: Terminated
研发用途: Arthritis Rheumatoid; Interaction
研究机构: University of Southern Denmark; Odense University Hospital; Hospital of South West Jutland; King Christian X´Hospital for Rheumatic Diseases; Sygehus Lillebaelt; Odense Patient Data Explorative Network
研发日期: May 25 2021
研发阶段: Phase 1 : Phase 2
Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.
LY294002
中文名称:2-吗啉代-8-苯基色酮
CAS号:154447-36-6
分子式: C19H17NO3 分子量: 307.34
产品形式: free base
研发状态: Terminated
研发用途: Neuroblastoma
研究机构: New Approaches to Neuroblastoma Therapy Consortium; SignalRX Pharmaceuticals Inc.; University of Southern California
研发日期: July 9 2015
研发阶段: Phase 1
LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.
Thioguanine (NSC 752)
中文名称: 硫鸟嘌呤
CAS号:154-42-7
分子式: C5H5N5S 分子量: 167.19
产品形式: free base
研发状态: Unknown status
研发用途: Lymphoblastic Leukemia Acute Childhood
研究机构: Vastra Gotaland Region
研发日期: Jan-17
研发阶段: Phase 2
Thioguanine (NSC 752, 6-Thioguanine, 2-Amino-6-purinethiol), a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.
Capecitabine (RO 09-1978)
中文名称:卡培他滨
CAS号:154361-50-9
分子式: C15H22FN3O6 分子量: 359.35
产品形式: free base
研发状态: Not yet recruiting
研发用途: Breast Cancer
研究机构: Novartis Pharmaceuticals; Novartis
研发日期: May 16 2024
研发阶段: Phase 1 : Phase 2
Capecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.
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