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临床前CDMO研发化合物筛选
Deoxycholic acid sodium salt
中文名称: 去氧胆酸钠
CAS号:302-95-4
分子式: C24H39NaO4 分子量: 414.55
产品形式: Sodium salt
研发状态: Completed
研发用途: Healthy
研究机构: Kythera Biopharmaceuticals
研发日期: Jun-12
研发阶段: Phase 1
Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) is specifically responsible for activating the TGR5 receptor (GPCR19) that stimulates brown adipose tissue (BAT) thermogenic activity.
Tretinoin (NSC 122758)
中文名称: 维生素A酸; 视黄酸
CAS号:302-79-4
分子式: C20H28O2 分子量: 300.40
产品形式: free base
研发状态: Not yet recruiting
研发用途: Breast Cancer
研究机构: Assiut University
研发日期: November 1 2023
研发阶段: --
Tretinoin (Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Rosiglitazone (BRL-49653) HCl
中文名称: 盐酸罗格列酮
CAS号:302543-62-0
分子式: C18H19N3O3S.HCl 分子量: 393.89
产品形式: HCl
研发状态: Terminated
研发用途: Non-small Cell Lung Cancer
研究机构: Sun Yat-sen University
研发日期: Mar-16
研发阶段: Phase 2
Rosiglitazone HCl (BRL-49653) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
Ingenol
中文名称:巨大戟二萜醇
CAS号:30220-46-3
分子式: C20H28O5 分子量: 348.43
产品形式: free base
研发状态: Completed
研发用途: Actinic Keratosis
研究机构: Icahn School of Medicine at Mount Sinai; LEO Pharma
研发日期: Mar-13
研发阶段: Phase 1
Ingenol, a plant-derived diterpenoid, is a weak PKC activator and possesses important anticancer activity.
Ademetionine
中文名称:S-腺苷-L-蛋氨酸
CAS号:29908-03-0
分子式: C15H22N6O5S 分子量: 398.44
产品形式: free base
研发状态: Withdrawn
研发用途: Esophageal Squamous Cell Carcinoma
研究机构: Institut de Recherches Internationales Servier; ADIR a Servier Group company; Servier
研发日期: May-25
研发阶段: Phase 1 : Phase 2
Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.
Methoxsalen
中文名称:花椒毒素; 8-甲氧基补骨脂素
CAS号:298-81-7
分子式: C12H8O4 分子量: 216.19
产品形式: free base
研发状态: Recruiting
研发用途: Advanced Solid Tumor Cancer
研究机构: Immunolight LLC
研发日期: December 8 2021
研发阶段: Phase 1
Methoxsalen (Xanthotoxin, NCI-C55903) is a naturally occurring photoactive substance found in the seeds of the Ammi majus (Umbelliferae) plant, used in the diagnosis and treatment of psoriasis; A CYP2A5/6 inhibitor.
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