CAS: 30220-46-3; (1Ar,2S,5R,5Ar,6S,8As,9R,10Ar)-5,5A,6-Trihydroxy-4-(Hydroxymethyl)-1,1,7,9-Tetramethyl-1A,2,5,5A,6,9,10,10A-Octahydro-1H-2,8A-Methanocyclopenta[a]Cyclopropa[e][10]Annulen-11-One

Ingenol-20-O-octanoate置于水体系中,化学反应生成巨大戟醇
参考文献:来自大戟的生物活性二萜酯
标题:来自大戟的生物活性二萜酯
摘要:摘要 通过分离制备薄层色谱法,从大戟中分离出两种促炎二萜酯.这些化合物被鉴定为20-脱氧姜黄醇3-O-当归醇,其在小鼠上的id 50 为0.18 μg,而新的酯化姜黄醇20-O-辛酸酯在小鼠皮肤上的id 50 为1.0 μg.
Doi:10.1016/s0031-9422(00)81076-6

专利信息

专利号:US-12098115-B2
优先权日:2016-09-15
标 题:Methods and compositions for terpenoid synthesis
发明人：GRENNING ALEXANDER JAMES
权利人:UNIV FLORIDA
摘要:In one aspect, the disclosure relates to methods for preparation of terpene and terpene-like molecules. In a further aspect, the disclosure relates to the products of the disclosed methods, i.e., terpene and terpene-like molecules prepared using the disclosed methods. Intermediates for the synthesis of a wide variety of terpenoids are γ-allyl Knoevenagel adducts or quasi γ-allyl Knoevenagel adducts are disclosed. In various aspects, methods of preparing terpenoids through these intermediates are disclosed. The methods can comprise α-alkylation of an allylic electrophile followed by ring-closure metathesis to a polycyclic terpenoid structure. In a further aspect, the disclosure pertains to terpenoid frameworks, and compounds prepared via disclosed oxidation and substitution reactions on the disclosed terpenoid frameworks. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-2013331427-A1
优先权日:2006-07-28
标题:Methods of stimulating cellular growth, synaptic, remodeling and consolidation of long-term memory
发明人：ALKON DANIEL L
权利人:BRNI NEUROSCIENCES INST; BRNI NEUROSCIENCES INST
摘要:The present invention provides methods of slowing or reversing the loss of memory and learning comprising the steps of contacting an effective amount of a PKC activator with a protein kinase C (PKC) in a subject identified with memory loss slowing or reversing memory loss. The present invention provides methods of stimulating cellular growth, neuronal growth, dendritic growth, dendritic spine formation, dendritic spine density, and the translocation of ELAV to proximal dendrites, and synaptic remodeling. The present invention also provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to stimulate the synthesis of proteins sufficient to consolidate long-term memory. The present invention also provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to downregulate PKC.

专利号:US-9416083-B2
优先权日:2011-10-04
标题 :Method of isolating ingenol
发明人：BELLIDO CABELLO DE ALBA MARIA LUZ; APPENDINO GIOVANNI; PAGANI ALBERTO; MUNOZ BLANCO EDUARDO
权利人:INDENA SPA
摘要:The present invention relates to a new method for isolating ingenol (C20H28O5) from mixtures of diterpenoid esters and ingenol esters in a single step. Ingenol isolated by means of this method can be used as a precursor for the synthesis of biologically active ingenol derivatives, such as ingenol-3-angelate and ingenol-3-tigliate.

专利号:US-9676698-B2
优先权日:2010-07-20
标 题:Method of producing ingenol-3-angelate
发明人：HOGBERG THOMAS; GRUE-SORENSEN GUNNAR; LIANG XIFU; HORNEMAN ANNE MARIE; PETERSEN ANDERS KLARSKOV
权利人:LEO LABORATORIES LTD
摘要:The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). n n n n n n n n n n Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.

专利号:US-2022118123-A1
优先权日:2019-02-22
标 题 :Combination of ar antagonists and targeted thorium conjugates
发明人：HAMMER STEFANIE; HAGEMANN URS BEAT; HAENDLER BERNARD; LEJEUNE PASCALE; ZITZMANN-KOLBE SABINE; SCHATZ CHRISTOPH; KARLSSON JENNY
权利人:BAYER AG; BAYER AS
摘要:The present invention covers combinations of at least two components, component A and component B, comprising component A being PSMA-TTC, and component B being an antiandrogen selected form AR antagonists such as from cyproterone acetate, bicalutamide, flutamide, nilutamide, enzalutamide, apalutamide, darolutamide or keto-darolutamide, or an AR degrader such as ARV-110, or an ARN-terminal domain binder such as EPI-506, or an antisense oligonucleotide that reduces AR expression such as EZN-4176 or AZD-5312, or an androgen synthesis inhibitor such as abiraterone, particularly abiraterone acetate, seviteronel, galeterone, orteronel or ketoconazole, or a dual AR antagonist and androgen synthesis inhibitor such as ODM-204. Another aspect of the present invention covers the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of a hyper-proliferative disease.

专利号:US-2019106684-A1
优先权日:2016-03-16
标题 :Modified cell
发明人：GRAHAM IAN; KING ANDREW
权利人:UNIV YORK
摘要:The present disclosure relates to nucleic acids that encode enzyme activities involved in the synthesis of lathyranes, intermediates in the synthesis of lathyranes and also compounds derived from lathyranes such as tiglianes, daphnanes and ingenanes; cells transformed with the nucleic acid molecules and vectors comprising the nucleic acid molecules.