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临床前CDMO研发化合物筛选
Etoposide (VP-16)
中文名称:依托泊苷
CAS号:33419-42-0
分子式: C29H32O13 分子量: 588.56
产品形式: free base
研发状态: Not yet recruiting
研发用途: Large Cell Neuroendocrine Carcinoma of the Lung
研究机构: Centre Leon Berard; Groupe Français de Pneumo-Cancérologie
研发日期: May-24
研发阶段: Phase 2
Etoposide (VP-16213,Vepesid,VP-16) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. Etoposide induces autophagy, mitophagy and apoptosis.
Buspirone HCl
中文名称:丁螺旋酮盐酸盐
CAS号:33386-08-2
分子式: C21H31N5O2.HCl 分子量: 421.96
产品形式: Hydrochloride
研发状态: Recruiting
研发用途: Opioid Use Disorder; Opioid Withdrawal; Opioid Craving; Anxiety
研究机构: Johns Hopkins University
研发日期: December 15 2022
研发阶段: Phase 2
Buspirone(Buspirone hydrochloride) is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect, used for anxiety disorders.
Diltiazem HCl
中文名称:盐酸地尔硫卓
CAS号:33286-22-5
分子式: C22H26N2O4S.HCl 分子量: 450.98
产品形式: Hydrochloride
研发状态: Active not recruiting
研发用途: Microvascular Angina; Coronary Vasospasm; Microvascular Ischemia of Myocardium
研究机构: Radboud University Medical Center
研发日期: October 25 2019
研发阶段: Phase 3
Diltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.
Caffeic Acid
中文名称:咖啡酸
CAS号:331-39-5
分子式: C9H8O4 分子量: 180.16
产品形式: free base
研发状态: Not yet recruiting
研发用途: Ischemic Stroke Acute
研究机构: Ying Gao; Dongzhimen Hospital of Beijing University of Chinese Medicine Beijing; Dongzhimen Hospital Beijing
研发日期: September 25 2022
研发阶段: Phase 2 : Phase 3
Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound. Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO).
Betrixaban
中文名称:贝曲西班
CAS号:330942-05-7
分子式: C23H22ClN5O3 分子量: 451.91
产品形式: free base
研发状态: Terminated
研发用途: VTE Prophylaxis
研究机构: Alexion Pharmaceuticals Inc.; Portola Pharmaceuticals LLC (a wholly owned subsidiary of Alexion Pharmaceuticals)
研发日期: July 13 2018
研发阶段: Phase 1
Betrixaban is a new, long-acting, oral and selective Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.
Vardenafil HCl Trihydrate
中文名称:盐酸瓦地那非三水合物
CAS号:330808-88-3
分子式: C23H32N6O4S.HCl.3H2O 分子量: 579.11
产品形式: Hydrochloride trihydrate
研发状态: Terminated
研发用途: Glioma; Brain Neoplasms; Brain Metastasis
研究机构: Cedars-Sinai Medical Center
研发日期: March 27 2012
研发阶段: Early Phase 1
Vardenafil HCl Trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
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