临床前CDMO研发筛选相关化合物

CDMO是Contract Development and Manufacturing Organization的缩写，即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药（特别是创新药）工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力，是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化：创新性合成路线设计、工艺参数优化. 2, 中试放大：实验室工艺向规模化生产的转化 3, 注册批生产：支持客户新药申报的验证批生产. 4, 商业化生产：药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测：2026年全球CDMO市场规模：预计达1,189亿美元 2033年全球CDMO市场规模：预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物，已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前，在多肽、ADC、CGT等新型药物赛道的驱动下，全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力，全球市占率有望持续提升，行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
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临床前CDMO研发化合物筛选

CAS: 34642-77-8

Amoxicillin Sodium

中文名称:阿莫西林钠
CAS号:34642-77-8
分子式: C16H18N3O5S.Na 分子量: 387.39
产品形式: Sodium Salt
研发状态: Recruiting
研发用途: Penicillin Allergy
研究机构: Geisinger Clinic
研发日期: March 4 2024
研发阶段: Early Phase 1
Amoxicillin Sodium (Clavulanate,Amoxycillin sodium) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.

CAS: 3458-28-4

D-Mannose

中文名称:D-甘露糖
CAS号:3458-28-4
分子式: C6H12O6 分子量: 180.16
产品形式: Free Base
研发状态: Recruiting
研发用途: Health
研究机构: Peking University Third Hospital
研发日期: April 1 2024
研发阶段: Not Applicable
D-mannose is a naturally occurring simple sugar that may help your body cleanse the urinary tract and maintain a healthy bladder lining.

CAS: 34580-14-8

Ketotifen Fumarate

中文名称: 富马酸酮替芬
CAS号:34580-14-8
分子式: C19H19NOS.C4H4O4 分子量: 425.50
产品形式: Fumarate
研发状态: Completed
研发用途: Breast Cancer; Iron Chelation
研究机构: Horus University
研发日期: January 14 2019
研发阶段: --
Ketotifen Fumarate(HC 20511 fumarate) is a fumaric acid salt of ketotifen which is a H1-antihistamine and mast cell stabilizer.

CAS: 345627-80-7

SNS-032 (BMS-387032)

中文名称:N-[5-[(5-叔丁基-1,3-恶唑-2-基)甲硫基]-1,3-噻唑-2-基]哌啶-4-甲酰胺
CAS号:345627-80-7
分子式: C17H24N4O2S2 分子量: 380.53
产品形式: free base
研发状态: Completed
研发用途: B-lymphoid Malignancies; Chronic Lymphocytic Leukemia; Mantle Cell Lymphoma; Multiple Myeloma
研究机构: Sunesis Pharmaceuticals
研发日期: Feb-07
研发阶段: Phase 1
SNS-032 (BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6. SNS-032 (BMS-387032) induces apoptosis.

CAS: 34552-83-5

Loperamide HCl

中文名称: 盐酸洛哌丁胺
CAS号:34552-83-5
分子式: C29H33ClN2O2.HCl 分子量: 513.50
产品形式: Hydrochloride
研发状态: Completed
研发用途: Healthy Participants
研究机构: Janssen Research & Development LLC
研发日期: January 17 2020
研发阶段: Phase 1
Loperamide HCl (ADL 2-1294,R-18553 hydrochloride) is a selective μ-opioid receptor agonist opioid with Ki of 3.3 nM, 15-fold and 350-fold selective over the δ subtype and the κ subtype of the opioid receptor, used against diarrhea resulting from gastroenteritis or inflammatory bowel disease.

CAS: 343-55-5

Dicloxacillin Sodium

中文名称:双氯西林钠
CAS号:343-55-5
分子式: C19H17Cl2N3O5S.H2O.Na 分子量: 510.32
产品形式: Sodium Salt
研发状态: Completed
研发用途: Healthy Volunteers; Drug-drug Interaction
研究机构: University of Southern Denmark
研发日期: February 7 2022
研发阶段: Phase 1
Dicloxacillin Sodium (Veracillin, BRL1702) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative aerobic and anaerobic bacteria.