网站主页>>>研发精选>>>临床前CDMO研发筛选相关化合物
CDMO是Contract Development and Manufacturing Organization的缩写,即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药(特别是创新药)工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力,是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化:创新性合成路线设计、工艺参数优化. 2, 中试放大:实验室工艺向规模化生产的转化 3, 注册批生产:支持客户新药申报的验证批生产. 4, 商业化生产:药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测:2026年全球CDMO市场规模:预计达1,189亿美元 2033年全球CDMO市场规模:预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物,已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前,在多肽、ADC、CGT等新型药物赛道的驱动下,全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力,全球市占率有望持续提升,行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
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临床前CDMO研发化合物筛选

  • Triciribine (NSC 154020)

    中文名称:曲西立滨
    CAS号:35943-35-2
    分子式: C13H16N6O4 分子量: 320.30
    产品形式: free base
    研发状态: Unknown status
    研发用途: Mucosa-Associated Lymphoid Tissue Lymphoma
    研究机构: National Taiwan University Hospital
    研发日期: Feb-16
    研发阶段: --
    Triciribine (NSC 154020, VD-0002, vqd-002, API-2, TCN) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.

  • Sodium Tauroursodeoxycholate (TUDC)

    中文名称:牛磺熊去氧胆酸钠
    CAS号:35807-85-3
    分子式: C26H44NNaO6S 分子量: 521.69
    产品形式: sodium salt
    研发状态: Recruiting
    研发用途: Amyotrophic Lateral Sclerosis
    研究机构: Humanitas Mirasole SpA; University of Ulm; University of Sheffield; University Hospital Tours; KU Leuven; UMC Utrecht; University of Dublin Trinity College; Bruschettini S.r.l.; Istituto Superiore di Sanità; Motor Neurone Disease Association
    研发日期: October 25 2021
    研发阶段: Phase 3
    Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.

  • Galanthamine

    中文名称:加兰他敏
    CAS号:357-70-0
    分子式: C17H21NO3 分子量: 287.35
    产品形式: free base
    研发状态: Completed
    研发用途: Alzheimer Disease; Dementia; Galantamine
    研究机构: Janssen-Cilag Pty Ltd
    研发日期: May-05
    研发阶段: --
    Galanthamine (Galantamine, Nivalin, Razadyne, Razadyne ER, Reminyl, Lycoremine) is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase. It is studied as a treatment for Alzheimer's disease and other central nervous system disorders.

  • Pemetrexed Disodium Hydrate

    中文名称:培美曲塞二钠
    CAS号:357166-30-4
    分子式: C20H21N5O6.5/2H2O.2Na 分子量: 516.42
    产品形式: Disodium Hydrate
    研发状态: Recruiting
    研发用途: Non Small Cell Lung Cancer Metastatic; ALK Gene Mutation
    研究机构: Centro di Riferimento Oncologico - Aviano
    研发日期: March 15 2024
    研发阶段: Phase 2
    Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates autophagy and apoptosis.

  • Carboprost

    中文名称:卡前列素
    CAS号:35700-23-3
    分子式: C21H36O5 分子量: 368.51
    产品形式: free base
    研发状态: Recruiting
    研发用途: Fibroid Uterus; Gynecologic Disease; Leiomyoma Uterine
    研究机构: Northwestern University
    研发日期: July 12 2022
    研发阶段: Early Phase 1
    Carboprost is a synthetic prostaglandin analogue of PGF2α with oxytocic properties.

  • Megestrol

    中文名称:甲地孕酮
    CAS号:3562-63-8
    分子式: C22H30O3 分子量: 342.47
    产品形式: Free Base
    研发状态: Terminated
    研发用途: Endometrial Cancer
    研究机构: Sunnybrook Health Sciences Centre; Ontario Institute for Cancer Research
    研发日期: July 5 2022
    研发阶段: Phase 1
    Megestrol, a synthetic progestin, is approved for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis. Megestrol acetate (Megace) is one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer.

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