CAS: 35943-35-2; (2R,3R,4S,5R)-2-(3-Amino-5-Methyl-1,4,5,6,8-Pentaazaacenaphthylen-1(5H)-yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol

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CAS号699011-59-1 4-(1-methylhydr... | CAS号6974-32-9 1-乙酰氧基-2,3,5-三苯... | CAS号699011-57-9 6-bromo-4-chlor... | CAS号699011-58-0 6-bromo-5-cyano... | CAS号24391-39-7 6-bromo-4-chlor... | CAS号24391-40-0 6-Bromo-4-oxo-4... | CAS号19393-83-0 4-氨基-6-溴-7H-吡咯并... | CAS号35943-36-3 4-(N-methyl-hyd...

📜6-Bromo-4-Chloro-5-Cyano-7-[2,3,5-Tri-O-Benzoyl-β-D-Ribofuranosyl]Pyrrolo[2,3-D]Pyrimidine置于palladium On Activated Charcoal Sodium Methylate,Ammonium Formate体系中,用 甲醇,乙醇,氯仿 用作溶剂,化学反应 20.5H,反应生成曲西瑞宾
参考文献:Triciribine 的改进全合成:具有抗肿瘤和抗病毒特性的三环核苷
标题:Triciribine 的改进全合成:具有抗肿瘤和抗病毒特性的三环核苷
摘要:我们描述了从 4-氨基-6-溴-5-氰基吡咯并[2,3-D]嘧啶开始,高效全合成曲西瑞宾,一种具有抗肿瘤和抗病毒特性的三环核苷.†为了纪念和庆祝 Leroy B. Townsend 教授 70 岁生日.
Doi:10.1081/ncn-120027815

专利信息

专利号:US-2004242897-A1
优先权日:2002-07-31
标题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:WO-2004011474-A1
优先权日:2002-07-31
标题:Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-6653468-B1
优先权日:2002-07-31
标 题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-4123524-A
优先权日:1977-06-08
标题:Synthesis of 6-amino-4-methyl-8-(β-D-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5-C]pyridazine-5'-phosphate as a novel compound and its utility against L-1210 mouse leukemia
发明人：TOWNSEND LEROY B; LEWIS ARTHUR F; ROTI ROTI LINDA W
权利人:US HEALTH EDUCATION & WELFARE
摘要:The compound 6-amino-4-methyl-8-(β-D-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazines-5'-phosphate (a nucleotide) as a new compound and its method of synthesis by phosphorylation of the known 6-amino-4-methyl-8-(β-D-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine (a nucleoside). The 5'-phosphate ester has utility against L-1210 mouse leukemia and has superior solubility over the parent compound which gives it a broader use pattern relative to dosage. This novel nucleotide also shows advantage in utilization as to pH over, for example, the hydrochloride salt which gives in solution a pH of 4 and is too acid for use.